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Technologies for localization and diagnosis of prostate cancer
Luleå University of Technology, Department of Computer Science, Electrical and Space Engineering, Signals and Systems.
2009 (English)In: Journal of Medical Engineering & Technology, ISSN 0309-1902, E-ISSN 1464-522X, Vol. 33, no 8, p. 585-603Article in journal (Refereed) Published
Abstract [en]

The gold standard for detecting prostate cancer (PCa), systematic biopsy, lacks sensitivity as well as grading accuracy. PSA screening leads to over-treatment of many men, and it is unclear whether screening reduces PCa mortality. This review provides an understanding of the difficulties of localizing and diagnosing PCa. It summarizes recent developments of ultrasound (including elastography) and MRI, and discusses some alternative experimental techniques, such as resonance sensor technology and vibrational spectroscopy. A comparison between the different methods is presented. It is concluded that new ultrasound techniques are promising for targeted biopsy procedures, in order to detect more clinically significant cancers while reducing the number of cores. MRI advances are very promising, but MRI remains expensive and MR-guided biopsy is complex. Resonance sensor technology and vibrational spectroscopy have shown promising results in vitro. There is a need for large prospective multicentre trials that unambiguously prove the clinical benefits of these new techniques.

Place, publisher, year, edition, pages
2009. Vol. 33, no 8, p. 585-603
National Category
Other Medical Engineering
Research subject
Medical Engineering for Healthcare
Identifiers
URN: urn:nbn:se:ltu:diva-4331DOI: 10.3109/03091900903111966Local ID: 242c1810-ae80-11de-8293-000ea68e967bOAI: oai:DiVA.org:ltu-4331DiVA: diva2:977195
Projects
Prostatacancer
Note
Validerad; 2009; 20091001 (ysko)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2017-11-24Bibliographically approved

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