Blood biomarkers for brain injury in concussed professional ice hockey playersShow others and affiliations
2014 (English)In: JAMA Neurology, ISSN 2168-6149, E-ISSN 2168-6157, Vol. 71, no 6, p. 684-692Article in journal (Refereed) Published
Abstract [en]
IMPORTANCE Lack of objective biomarkers for brain damage hampers acute diagnosis and clinical decision making about return to play after sports-related concussion. OBJECTIVES To determine whether sports-related concussion is associated with elevated levels of blood biochemical markers of injury to the central nervous system and to assess whether plasma levels of these biomarkers predict return to play in professional ice hockey players with sports-related concussion. DESIGN, SETTING, AND PARTICIPANTS Multicenter prospective cohort study involving all 12teams of the top professional ice hockey league in Sweden, the Swedish Hockey League. Two hundred eighty-eight professional ice hockey players from 12 teams contesting during the 2012-2013 season consented to participate. All players underwent clinical preseason baseline testing regarding concussion assessment measures. Forty-seven players from 2 of the 12 ice hockey teams underwent blood sampling prior to the start of the season. Thirty-five players had a concussion from September 13, 2012, to January 31, 2013; of these players, 28 underwent repeated blood sampling at 1, 12, 36, and 144 hours and when the players returned to play. MAIN OUTCOMES AND MEASURES Total tau, S-100 calcium-binding protein B, and neuron-specific enolase concentrations in plasma and serum were measured.
Place, publisher, year, edition, pages
2014. Vol. 71, no 6, p. 684-692
National Category
Other Health Sciences
Research subject
Health Science
Identifiers
URN: urn:nbn:se:ltu:diva-5487DOI: 10.1001/jamaneurol.2014.367ISI: 000340479800005PubMedID: 24627036Scopus ID: 2-s2.0-84902172640Local ID: 399b6653-e5f7-4b98-8fdb-f79957fddf9dOAI: oai:DiVA.org:ltu-5487DiVA, id: diva2:978361
Note
Validerad; 2014; 20140624 (andbra);
For correction, see: Error in Table and Figure. JAMA Neurol. 2016;73(9):1160. doi:10.1001/jamaneurol.2016.2806
2016-09-292016-09-292023-08-29Bibliographically approved