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Nanofibrillated cellulose composite hydrogel for the replacement of the Nucleus Pulposus
École Polytechnique Fédérale de Lausanne.
Luleå University of Technology, Department of Engineering Sciences and Mathematics, Material Science.
École Polytechnique Fédérale de Lausanne.
École Polytechnique Fédérale de Lausanne.
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2011 (English)In: Acta Biomaterialia, ISSN 1742-7061, E-ISSN 1878-7568, Vol. 7, no 9, p. 3412-3421Article in journal (Refereed) Published
Abstract [en]

The swelling and compressive mechanical behavior as well as the morphology and biocompatibility of composite hydrogels based on Tween® 20 trimethacrylate (T3), N-vinyl-2-pyrrolidone (NVP) and nanofibrillated cellulose (NFC) were assessed in the present study. The chemical structure of T3 was verified by FTIR and 1H NMR and the degree of substitution (DS) was found to be around 3. Swelling ratios of neat hydrogels composed of different concentrations of T3 and NVP were found to range from 1.5 to 5.7 with decreasing concentration of T3. Various concentrations of cellulose nanofibrils (0.2 to 1.6 wt%) were then used to produce composite hydrogels that showed lower swelling ratios than neat ones for a given T3 concentration. Neat and composite hydrogels exhibited typical non-linear response under compression. All composite hydrogels showed an increase in elastic modulus compared to neat hydrogel of about 3 to 8-fold, reaching 18 kPa at 0% strain and 62 kPa at 20% strain for the hydrogel with the highest NFC content. All hydrogels presented a porous and homogeneous structure, with interconnected pore cells of around 100 nm in diameter. The hydrogels are biocompatible. The results of this study demonstrate that composite hydrogels reinforced with NFC may be viable as nucleus pulposus implant due to their adequate swelling ratio that may restore annulus fibrosus loading and their increased mechanical properties that could possibly restore the height of intervertebral discs.

Place, publisher, year, edition, pages
2011. Vol. 7, no 9, p. 3412-3421
National Category
Bio Materials
Research subject
Wood and Bionanocomposites
Identifiers
URN: urn:nbn:se:ltu:diva-5725DOI: 10.1016/j.actbio.2011.05.029Local ID: 3e72efd5-1442-43bc-bc02-9729a7836c1aOAI: oai:DiVA.org:ltu-5725DiVA: diva2:978600
Note
Validerad; 2011; 20110530 (ysko)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2017-11-24Bibliographically approved

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