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Fibrous cellulose nanocomposite scaffolds prepared by partial dissolution for potential use as ligament or tendon substitutes
Luleå University of Technology, Department of Engineering Sciences and Mathematics, Material Science.ORCID iD: 0000-0001-8909-3554
Luleå University of Technology, Department of Engineering Sciences and Mathematics, Material Science.ORCID iD: 0000-0003-4762-2854
Laboratoire d‘Evaluation des Matériaux Implantables (LEMI), Technopole Bordeaux-Montesquieu, 2 allée François Magendie, Martillac.
Laboratoire d‘Evaluation des Matériaux Implantables (LEMI), Technopole Bordeaux-Montesquieu, 2 allée François Magendie, Martillac.
2012 (English)In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 87, no 3, p. 2291-2298Article in journal (Refereed) Published
Abstract [en]

Fibrous cellulose nanocomposites scaffolds were developed and evaluated for their potential as ligament or tendon substitute. The nanocomposites were prepared by partial dissolution of cellulose nanofiber networks using ionic liquid at 80 °C for different time intervals. Scanning electron microscopy study indicated that partial dissolution resulted in fibrous cellulose nanocomposites where the dissolved cellulose nanofibers formed the matrix phase and the undissolved or partially dissolved nanofibers formed the reinforcing phase. Mechanical properties of the composites in simulated body conditions (37 °C and 95% RH) after sterilization using gamma rays was comparable to those of natural ligaments and tendons. Stress relaxation studies showed stable performance towards cyclic loading and unloading, further confirming the possibility for using these composites as ligament/tendon substitute. In-vitro biocompatibility showed a positive response concerning adhesion/proliferation and differentiation for both human ligament and endothelial cells. Prototypes based on the cellulose composite were developed in the form of tubules to be used for further studies.

Place, publisher, year, edition, pages
2012. Vol. 87, no 3, p. 2291-2298
National Category
Bio Materials
Research subject
Wood and Bionanocomposites
Identifiers
URN: urn:nbn:se:ltu:diva-5864DOI: 10.1016/j.carbpol.2011.10.063ISI: 000299969700059Scopus ID: 2-s2.0-83655161311Local ID: 40e8f212-f2ea-4ee9-a872-34d0a054a3feOAI: oai:DiVA.org:ltu-5864DiVA, id: diva2:978740
Note
Validerad; 2012; 20111114 (ysko)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved

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Mathew, Aji P.Oksman, Kristiina

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