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Comment on "disruption in the inhibitory architecture of the cell minicolumn: implications for autism"
Luleå University of Technology, Department of Computer Science, Electrical and Space Engineering, Embedded Internet Systems Lab.
2004 (English)In: The Neuroscientist, ISSN 1073-8584, E-ISSN 1089-4098, Vol. 10, no 3, p. 189-191Article in journal, Editorial material (Other academic) Published
Abstract [en]

Narrow neural columns have been suggested to be a neuroanatomical abnormality in autism. A previous hypothetical explanation, an unbalance between excitatory and inhibitory lateral feedback in the neocortex, has been found to be difficult to reconcile with the relatively high comorbidity of autism with epilepsy. Two alternative explanations are discussed, an early low capacity for producing serotonin, documented in autism, and insufficient production of nitric oxide. An early low level of serotonin has in animal experiments caused narrow neural columns. Insufficient nitric oxide is known from neural network theory to cause narrow neural columns.

Place, publisher, year, edition, pages
2004. Vol. 10, no 3, p. 189-191
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Research subject
Industrial Electronics
Identifiers
URN: urn:nbn:se:ltu:diva-5893DOI: 10.1177/1073858404263493ISI: 000221529800010Scopus ID: 2-s2.0-2442660168Local ID: 414b2230-2601-11df-be83-000ea68e967bOAI: oai:DiVA.org:ltu-5893DiVA, id: diva2:978769
Note
Godkänd; 2004; 20100302 (andbra)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved

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Gustafsson, Lennart

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