Ultra-fine grinding involves a large number of parameters in its operation. In this paper, four important parameters of the Drais stirred ball mill, i.e., the bead density, slurry density, mill speed, and the effect of dispersant were selected for investigation. The experimental work was based on a factorial design and 27 milling tests were conducted. It is found that the bead density has an optimum value of 3.7 g/cc in this investigation. A lower slurry density and a smaller amount of dispersant appear to be better conditions. The mill speed should be as high as possible within the speed limit tested in this work for the best process efficiency.