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Spectroscopic monitoring of environmentally benign anti-solvent crystallization
Michigan State University.
1996 (English)In: Journal of Crystal Growth, ISSN 0022-0248, E-ISSN 1873-5002, Vol. 166, no 1-4, p. 967-970Article in journal (Refereed) Published
Abstract [en]

There are very few studies dealing with the fundamentals of anti-solvent crystallization, even though this crystallization method is widely used in the pharmaceutical industry. Anti-solvent crystallization is accomplished by adding a miscible anti-solvent into a mixture of solute and solvent, effectively reducing the solubility of the solute in the solvent, and thus, causing the crystallization of the solute. Unfortunately, many of the anti-solvents used today are chlorinated hydrocarbons suspected of environmental damage. The current research demonstrates the use of environmentally benign solvents for anti-solvent crystallization and new approaches for monitoring of the solvent behavior during an anti-solvent crystallization. Results are presented confirming the efficacy of various water and ester systems for anti-solvent crystallization. Furthermore, the application of fluorescence spectroscopy for monitoring these crystallizations is demonstrated.

Place, publisher, year, edition, pages
1996. Vol. 166, no 1-4, p. 967-970
National Category
Bioprocess Technology
Research subject
Biochemical Process Engineering
Identifiers
URN: urn:nbn:se:ltu:diva-7586DOI: 10.1016/0022-0248(95)00920-5Local ID: 5f8aaa20-3bc6-11de-a8ec-000ea68e967bOAI: oai:DiVA.org:ltu-7586DiVA, id: diva2:980476
Note
Upprättat; 1996; 20090508 (ysko)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2017-11-24Bibliographically approved

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Berglund, Kris

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