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Formation of cocrystals from stoichiometric solutions of incongruently saturating systems by spray drying
Luleå University of Technology, Department of Health Sciences, Medical Science.ORCID iD: 0000-0002-6050-0432
Luleå University of Technology, Department of Health Sciences, Medical Science.ORCID iD: 0000-0002-0654-5410
2010 (English)In: Crystal Growth & Design, ISSN 1528-7483, E-ISSN 1528-7505, Vol. 10, no 8, p. 3302-3305Article in journal (Refereed) Published
Abstract [en]

Spray drying is a well established technique for material processing and scale-up. This study investigated the formation of pharmaceutical cocrystals by spray drying. The cocrystal formation mechanisms in spray-drying and solution methods, based on triangular phase diagrams, are discussed. The solvent evaporation of stoichiometric solutions of incongruently saturating cocrystals resulted in a mixture of phases, as dictated by the thermodynamic phase diagram. In contrast, spray drying of similar solutions of incongruently saturating systems generated pure cocrystals. It is thus suggested that the formation of cocrystals by spray drying could be kinetically controlled and/or mediated by the glassy state of the material.

Place, publisher, year, edition, pages
2010. Vol. 10, no 8, p. 3302-3305
National Category
Other Health Sciences
Research subject
Health Science
Identifiers
URN: urn:nbn:se:ltu:diva-7596DOI: 10.1021/cg100451qISI: 000280471700002Scopus ID: 2-s2.0-77955338170Local ID: 5fb42e60-a6cb-11df-a707-000ea68e967bOAI: oai:DiVA.org:ltu-7596DiVA, id: diva2:980486
Note
Validerad; 2010; 20100813 (ysko)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved

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Alhalaweh, AmjadVelaga, Sitaram

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