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Enantiomeric separations of remoxipride, propranolol, and trimipramine on CHIRAL-AGP using micellar chromatography and anionic additives
Department of Analytical Pharmaceutical Chemistry, University of Uppsala Biomedical Center, Uppsala, Sweden.
Department of Analytical Pharmaceutical Chemistry, University of Uppsala Biomedical Center, Uppsala, Sweden.
Department of Analytical Pharmaceutical Chemistry, University of Uppsala Biomedical Center, Uppsala, Sweden.
1993 (English)In: Chirality, ISSN 0899-0042, E-ISSN 1520-636X, Vol. 5, no 4, p. 224-228Article in journal (Refereed) Published
Abstract [en]

The retentions and enantiomeric resolutions of remoxipride, propranolol, and trimipramine were studied using a CHIRAL-AGP column with micellar mobile phases and aliphatic, anionic additives. The retentions of the compounds, which in neat buffer solution were very high (k > 50), could be decreased to k < 10 by adding a mixture of Tween® 20 and heptanoic acid to the mobile phase. The presence of the aliphatic acid was essential in order to increase the enantiomeric selectivity. An efficiency enhancement was obtained by increasing the temperature. With a mobile phase composition optimized for the separation of remoxipride, the possibility of detecting levels of the enantiomeric impurity (R-remoxipride) down to 0.025% in the drug was demonstrated.

Place, publisher, year, edition, pages
1993. Vol. 5, no 4, p. 224-228
Identifiers
URN: urn:nbn:se:ltu:diva-8149DOI: 10.1002/chir.530050406Local ID: 69eaaa10-ec48-11dd-99cd-000ea68e967bOAI: oai:DiVA.org:ltu-8149DiVA, id: diva2:981040
Note

Upprättat; 1993; 20090127 (andbra)

Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-01-12Bibliographically approved

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