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Skeletal muscle telomere length is not impaired in healthy physically active old women and men
Örebro University, Department of Health Sciences.
Örebro University, Department of Health Sciences.
2008 (English)In: Muscle and Nerve, ISSN 0148-639X, E-ISSN 1097-4598, Vol. 37, no 4, p. 467-72Article in journal (Refereed) Published
Abstract [en]

We have previously shown that the number of satellite cells is lower in old than young men and women. The aim of this study was to further explore the effects of aging on the regenerative potential of skeletal muscle in 16 young and 26 old men and women with comparable physical activity level (young, 25 +/- 4 years; old, 75 +/- 4 years). Mean and minimum telomere lengths were determined using Southern blot analyses on biopsies obtained from the tibialis anterior muscle. There were no significant age or gender effects on mean and minimal telomeric lengths, suggesting that the replicative potential in the remaining satellite cells in the tibialis anterior muscle is not impaired with increasing age and the existence of in vivo regulatory mechanisms allowing the maintenance of telomere length. These results imply that moderate physical activity regularly performed by old subjects is not associated with accelerated telomere loss

Place, publisher, year, edition, pages
2008. Vol. 37, no 4, p. 467-72
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URN: urn:nbn:se:ltu:diva-9446DOI: 10.1002/mus.20964Local ID: 810f28f0-15f8-11dd-b7d2-000ea68e967bOAI: oai:DiVA.org:ltu-9446DiVA, id: diva2:982384
Note
Upprättat; 2008; 20080429 (andbra)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2017-11-24Bibliographically approved

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