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Biocomposite hydrogels with carboxymethylated, nanofibrillated cellulose powder for replacement of the nucleus pulposus
Laboratoire de Technologie des Composites et Polymères (LTC) Ecole Polytechnique Fédérale de Lausanne.
Laboratoire de Technologie des Composites et Polymères (LTC) Ecole Polytechnique Fédérale de Lausanne.
Laboratoire de Technologie des Composites et Polymères (LTC) Ecole Polytechnique Fédérale de Lausanne.
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2011 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 12, no 5, p. 1419-1427Article in journal (Refereed) Published
Abstract [en]

Biocomposite hydrogels with carboxymethylated, nanofibrillated cellulose (c-NFC) powder were prepared by UV polymerization of N-vinyl-2-pyrrolidone with Tween 20 trimethacrylate as a crosslinking agent for replacement of the native, human nucleus pulposus (NP) in intervertebral discs. The swelling ratios and the moduli of elasticity in compression of neat and biocomposite hydrogels were evaluated in dependence of c-NFC concentration (ranging from 0 to 1.6% v/v) and degree of substitution (DS, ranging from 0 to 0.23). The viscoelastic properties in shear and the material relaxation behavior in compression were measured for neat and biocomposite hydrogels containing 0.4% v/v of fibrils (DS ranging from 0 to 0.23) and their morphologies were characterized by cryo-scanning electron microscopy (cryo-SEM). The obtained results show that the biocomposite hydrogels can successfully mimic the mechanical and swelling behavior of the NP. In addition, the presence of the c-NFC show lower strain values after cyclic compression tests and consequently create improved material relaxation properties, compared to neat hydrogels. Among the tested samples, the biocomposite hydrogel containing 0.4% v/v of c-NFC with a DS of 0.17 shows the closest behavior to native NP. Further investigation should focus on evaluation and improvement of the long-term relaxation behavior.

Place, publisher, year, edition, pages
2011. Vol. 12, no 5, p. 1419-1427
National Category
Bio Materials
Research subject
Wood and Bionanocomposites
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URN: urn:nbn:se:ltu:diva-9626DOI: 10.1021/bm101131bISI: 000290246400004Scopus ID: 2-s2.0-79955796597Local ID: 84a55b70-b5ed-412f-a047-ea965846154eOAI: oai:DiVA.org:ltu-9626DiVA, id: diva2:982564
Note
Validerad; 2011; 20110317 (andbra)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved

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Eyholzer, ChristianOksman, Kristiina

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