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A combined tactile and Raman probe for tissue characterization—design considerations
Luleå University of Technology, Department of Computer Science, Electrical and Space Engineering, Signals and Systems.
Luleå University of Technology, Department of Computer Science, Electrical and Space Engineering, Signals and Systems. Department of Signals and Systems, Chalmers University of Technology, 412 96 Gothenburg, Sweden; MedTech West, Sahlgrenska University Hospital, Blå Stråket 7, 413 45 Gothenburg, Sweden.
Department of Applied Physics and Electronics, Umeå University, 901 87 Umeå, Sweden.
Luleå University of Technology, Department of Computer Science, Electrical and Space Engineering, Signals and Systems.ORCID iD: 0000-0003-3268-1691
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2012 (English)In: Measurement science and technology, ISSN 0957-0233, E-ISSN 1361-6501, Vol. 23, no 6, article id 065901Article in journal (Refereed) Published
Abstract [en]

Histopathology is the golden standard for cancer diagnosis and involves the characterization of tissue components. It is labour intensive and time consuming. We have earlier proposed a combined fibre-optic near-infrared Raman spectroscopy (NIR-RS) and tactile resonance method (TRM) probe for detecting positive surgical margins as a complement to interoperative histopathology. The aims of this study were to investigate the effects of attaching an RS probe inside a cylindrical TRM sensor and to investigate how laser-induced heating of the fibre-optic NIR-RS affected the temperature of the RS probe tip and an encasing TRM sensor. In addition, the possibility to perform fibre-optic NIR-RS in a well-lit environment was investigated. A small amount of rubber latex was preferable for attaching the thin RS probe inside the TRM sensor. The temperature rise of the TRM sensor due to a fibre-optic NIR-RS at 270 mW during 20 s was less than 2 °C. Fibre-optic NIR-RS was feasible in a dimmed bright environment using a small light shield and automatic subtraction of a pre-recorded contaminant spectrum. The results are promising for a combined probe for tissue characterization.

Place, publisher, year, edition, pages
2012. Vol. 23, no 6, article id 065901
Keywords [en]
tactile sensor, Raman spectroscopy, biological tissue
National Category
Other Medical Engineering
Research subject
Medical Engineering for Healthcare; Centre - Centre for Biomedical Engineering and Physics (CMTF)
Identifiers
URN: urn:nbn:se:ltu:diva-14652DOI: 10.1088/0957-0233/23/6/065901ISI: 000304187300025Scopus ID: 2-s2.0-84862059679Local ID: e11febed-b17a-406c-983e-8b9bcb17af5fOAI: oai:DiVA.org:ltu-14652DiVA, id: diva2:987625
Note

Validerad; 2012; 20120507 (mornyb)

Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2024-03-26Bibliographically approved

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Nyberg, MorganCandefjord, StefanRamser, KerstinLindahl, Olof

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