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  • 1.
    Haupt, Dan
    et al.
    Department of Analytical Pharmaceutical Chemistry, Uppsala University Biomedical Centre, Uppsala Sweden.
    Pettersson, Carl
    Department of Analytical Pharmaceutical Chemistry, Uppsala University Biomedical Centre, Uppsala Sweden.
    Westerlund, Douglas
    Department of Analytical Pharmaceutical Chemistry, Uppsala University Biomedical Centre, Uppsala Sweden.
    Separation of (R)- and (S)-naproxen using micellar chromatography and an alpha 1-acid-glycoprotein column: application for chiral monitoring in human liver microsomes by coupled-column chromatography1992In: Journal of Biochemical and Biophysical Methods, ISSN 0165-022X, E-ISSN 1872-857X, Vol. 25, no 4, p. 273-84Article in journal (Refereed)
    Abstract [en]

    A column-switching system for fast determination of (R)- and (S)-naproxen in liver microsomes has been developed. The centrifuged sample was injected directly onto a pre-column with octadecylcoated silica. The retained analytes were then directed to an alpha 1-AGP column using a mobile phase composed of phosphate buffer (pH 6.5), dimethylocytylamine (30 mM) and the nonionic surfactant, Tween 20 (40 g/l). The method gave high absolute recoveries and good repeatabilities: 99.6% (1.7% relative standard deviation) and 94.9% (2.4% R.S.D.) for the (R)- and (S)-naproxen, respectively. The use of a surfactant in combination with an aliphatic amine in the mobile phase involves reduced retention times with retained enantioselectivity. Furthermore, the presence of the surfactant makes it possible to inject biological samples directly into the chromatographic system.

  • 2.
    Ramser, Kerstin
    et al.
    Luleå University of Technology, Department of Computer Science, Electrical and Space Engineering, Signals and Systems.
    Wenseleers, Wim
    Department of Physics, University of Antwerp.
    Dewilde, Sylvia
    Department of Biomedical Science, University of Antwerp.
    Doorslaer, Sabine Van
    Department of Physics, University of Antwerp.
    Moens, Luc
    Department of Biomedical Science, University of Antwerp.
    Hanstorp, Dag
    Department of Physics, Göteborgs University.
    A combined micro-resonance Raman and absorption set-up enabling in vivo studies under varying physiological conditions: the nerve globin in the nerve cord of Aphrodite aculeata2007In: Journal of Biochemical and Biophysical Methods, ISSN 0165-022X, E-ISSN 1872-857X, Vol. 70, no 4, p. 627-633Article in journal (Refereed)
    Abstract [en]

    We hereby report on the design of a set-up combining micro-resonance Raman and absorption spectroscopy with a microfluidic system. The set-up enabled us to study the nerve globin of Aphrodite aculeata in the functional isolated nerve cord under varying physiological conditions for extended periods of time. The oxygenation cycle of the organism was triggered by utilizing the microfluidic system that allowed for a fast switch between aerobic and anaerobic conditions. The nerve globin was found to very easily shift from a penta-coordinated high spin ferrous form to the oxy state upon a change from anaerobic to aerobic conditions. The observed fast reaction to varying O2 concentrations supports an oxygen-carrying and/or -storing function of the nerve globin. In addition, by combining resonance Raman and absorption spectroscopy, the physiological response could be distinguished from light-induced effects.

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