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  • 1.
    Alhalaweh, Amjad
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Andersson, Staffan
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Velaga, Sitaram
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Preparation of Zolmitriptan-Chitosan microparticles by spray drying for nasal delivery2009In: European Journal of Pharmaceutical Sciences, ISSN 0928-0987, E-ISSN 1879-0720, Vol. 38, no 3, p. 206-214Article in journal (Refereed)
    Abstract [en]

    The objective of this study was to use spray drying to prepare mucoadhesive dry powders of the antimigraine drug, zolmitriptan, in combination with the natural polymer, chitosan, for nasal administration. The effect of type, molecular weight, and proportion of chitosan on the powder and particle characteristics was also studied. Solutions containing different proportions of chitosans were prepared and spray dried. The chemical stability and content of the drug were determined by HPLC. The morphology and size range of the microparticles were also determined. Solid-state analysis was undertaken using thermal methods (DSC/MDSC and TGA), powder X-ray diffraction (PXRD), and Fourier transform infra-red spectroscopy (FT-IR). The drug release profiles were investigated and the time required to reach maximum solution concentrations (Tmax) was used for comparison. The drug was chemically stable, with a 93-105% loading in the microparticles. The microparticles were spherical with a narrow size distribution, irrespective of the formulation. Phase separation was observed for formulations containing less than 90% (w/w) chitosan, irrespective of the type. In contrast, in the formulation containing 90% (w/w) chitosan, the drug was molecularly dispersed. FT-IR studies showed that the bands corresponding to intermolecular hydrogen bonding were broader and more diffuse when zolmitriptan was amorphous. The formation of a hydrogen bond between drug and chitosans was also observed. Tmax increased as the proportion of chitosan decreased, and was proportional to the molecular weight of the chitosan in the formulation containing 90% (w/w) chitosan. Spray drying is a suitable technique for making mucoadhesive dry powders of zolmitriptan and chitosan for nasal application. The dispersion and release of the drug was affected by the properties and composition of the chitosan.

  • 2.
    Andersson, Staffan
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Långtidsregistrering av fysiologiska mätsignaler: igår idag och i morgon2005In: Klinisk fysiologi: dåtid, nutid och framtid, Luleå: Luleå tekniska universitet, 2005, p. 164-170Chapter in book (Other academic)
  • 3. Andersson, Staffan
    Swedish Association of Urology. Proceedings of the spring meeting 1988 and the annual meeting 1988. Stockholm, May 26-27, 1988 and Stockholm, November 29-December 2, 1988. Abstracts1990In: Scandinavian Journal of Urology and Nephrology, Supplementum, ISSN 0300-8886, E-ISSN 1651-2537, Vol. Suppl. 133, p. 1-51Article in journal (Refereed)
  • 4. Andersson, Staffan
    Thermography and plethysmography in the diagnosis of deep venous thrombosis.: a comparison with phlebography1986In: Acta Medica Scandinavica, ISSN 0001-6101, Vol. 219, no 4, p. 359-366Article in journal (Refereed)
    Abstract [en]

    Ninety-two patients with suspected unilateral deep venous thrombosis (DVT) in the lower limb were examined by thermography, plethysmography and phlebography. ROC analysis (Receiver Operating Characteristics) was used to evaluate discrimination thresholds and to compare thermography and plethysmography (four variables) with phlebography. The sensitivity of thermography, 85% (94% for out-patients), was higher than that of plethysmography (58-79%) for the discrimination thresholds chosen. The specificity of thermography was low, 39% (42% for out-patients) or 55%, if obvious relevant clinical findings were included in the evaluation. The specificity of plethysmography was much higher (80-97%). Optimum combination of the four plethysmographic variables showed predictive values of 93-94%, while combination of thermography and plethysmographic variables showed higher predictive values (95-97%), mostly because of a higher sensitivity of thermography for distal DVT. A possible reduction of the number of phlebographic examinations by at least 50% and a cost reduction of 25% could have been obtained without any appreciable loss of diagnostic accuracy. A follow-up study of 112 consecutive patients, examined according to the recommended screening method, showed a reduction of phlebographic examinations by 62%.

  • 5. Andersson, Staffan
    et al.
    Bjerle, P
    Department of Clinical Physiology, Umeå university.
    Hentschel, J
    Department of Clinical Physiology, Umeå university.
    Kronström, A
    Department of Clinical Physiology, Umeå university.
    Niklasson, U
    Department of Clinical Physiology, Umeå university.
    Continuous and stepwise cystometry through suprapubic catheters: effect of infusion pattern and infusion rate on the cystometrogram of the normal human bladder1989In: Clinical Physiology, ISSN 0144-5979, E-ISSN 1365-2281, Vol. 9, no 1, p. 89-96Article in journal (Refereed)
    Abstract [en]

    Continuous cystometry at two filling rates (50 and 100 ml min-1) and stepwise cystometry (successive rapid volume infusions followed by bladder wall relaxation) were performed in 12 healthy subjects. Suprapubic catheters were used for infusion and recording of perivesical and intravesical pressures. The continuous cystometrograms obtained at filling rates of 50 and 100 ml min-1, respectively, did not differ with respect to desire to void, transmural pressure increase or bladder capacity. Stepwise cystometry allowed the bladders to be filled to a slightly larger volume than during continuous cystometry, but with comparatively lower transmural pressures only at very large distension of the bladder. There was considerable inter-individual variation in transmural pressure at both continuous and stepwise cystometry. Stepwise cystometry did not appear to provide any important additional information about pressure-volume relationship in the normal human bladder than could be obtained at routine clinical cystometry

  • 6. Andersson, Staffan
    et al.
    Forsberg, Håkan
    Central Hospital Boden, Department of Internal medicine.
    Olofson, BO
    Central Hospital Boden, Department of Internal medicine.
    Backman, C
    Central Hospital Boden, Department of Internal medicine.
    Henriksson, A
    Department of Internal Medicine, University Hospital, Umeå.
    Echocardiographic features of myotonic dystrophy1989In: American Journal of Noninvasive Cardiology, ISSN 0258-4425, Vol. 3, no 6, p. 354-358Article in journal (Refereed)
    Abstract [en]

    Thirty adult patients with myotonic dystrophy from a defined population in northern Sweden were examined by echocardiograms were found in 1 of 7 (14%) patients with mild disease, 7 of 13 (54%) patients with moderate disease, and 6 of 10 (60%) patients with severe disease

  • 7. Andersson, Staffan
    et al.
    Forsberg, Håkan
    Department of Internal Medicine, Central Hospital, Boden.
    Olofsson, BO
    Department of Internal Medicine, Central Hospital, Boden.
    Eriksson, Anders
    Department of Internal Medicine, Central Hospital, Boden.
    Cardiac involvement in congenital myotonic dystrophy1990In: British Heart Journal, ISSN 0007-0769, Vol. 63, no 2, p. 119-121Article in journal (Refereed)
    Abstract [en]

    Seven young patients (mean age 19 years 8 months) with congenital myotonic dystrophy and with defined symptoms at birth were investigated by electrocardiography and echocardiography. None had cardiovascular symptoms. Electrocardiograms or echocardiograms or both were abnormal in all patients. Atrioventricular and intraventricular conduction defects were the most common electrocardiographic abnormalities and were seen in five patients. The echocardiographic examinations showed impaired left ventricular systolic function in one patient. Other echocardiographic findings were a small left ventricle and atrium, minor valve defects, and mitral valve prolapse. This study shows that the heart is often affected in young patients with congenital myotonic dystrophy. The specialised conduction system is often affected and so too is the myocardium, causing impaired systolic function.

  • 8. Andersson, Staffan
    et al.
    Forsberg, Håkan
    Department of Internal Medicine, University Hospital, Umeå.
    Olofsson, BO
    Department of Internal Medicine, University Hospital, Umeå.
    Henriksson, A
    Department of Internal Medicine, University Hospital, Umeå.
    Bjerle, P
    Department of Internal Medicine, University Hospital, Umeå.
    24-hour electrocardiographic study in myotonic dystrophy1988In: Cardiology, ISSN 0008-6312, E-ISSN 1421-9751, Vol. 75, no 4, p. 241-249Article in journal (Refereed)
    Abstract [en]

    Thirty-eight consecutive adult patients with myotonic dystrophy were included in a study with electrocardiography at rest and 24-hour ambulatory electrocardiography. The patients were subdivided into three groups according to the severity of the disease. The prevalence of abnormal electrocardiograms at rest was 31, 50 and 100% in patients with mild, moderate and severe disease, respectively. The main characteristics observed at ambulatory electrocardiography were a high frequency of sinus bradycardia (58%) and intermittent atrioventricular block II (8%). These bradyarrhythmias were not correlated to the severity of the disease. Sustained atrial fibrillation or flutter was found in 3 patients (8%), all with the most severe form of the disease. Ambulatory electrocardiography should be used deliberately in the evaluation of patients with myotonic dystrophy and symptoms compatible with cardiac arrhythmias.

  • 9. Andersson, Staffan
    et al.
    Kronström, A
    Bjerle, P
    Umeå universitet.
    Bladder wall relaxation and its dependency on transmural pressure and infusion rate during cystometry: in vivo studies in the rat1988In: Urologia internationalis, ISSN 0042-1138, E-ISSN 1423-0399, Vol. 43, no 3, p. 157-9Article in journal (Refereed)
    Abstract [en]

    Cystometry at different infusion rates was performed in 7 rats in vivo. The bladders were furthermore allowed to relax from different transmural pressures. When distension of the bladder was moderate, relative relaxation was small and almost independent of transmural pressure and infusion rate. When distended to large volumes, however, there was a marked increase in bladder wall relaxation and the relaxation increased with increasing infusion rates. These findings indicate the importance of standardization of the cystometric procedure

  • 10. Andersson, Staffan
    et al.
    Kronström, A
    Department of Clinical Physiology, University Hospital, Umeå.
    Bjerle, P
    Department of Clinical Physiology, University Hospital, Umeå.
    Viscoelastic properties of the normal human bladder1989In: Scandinavian Journal of Urology and Nephrology, ISSN 0036-5599, E-ISSN 1651-2065, Vol. 23, no 2, p. 115-120Article in journal (Refereed)
    Abstract [en]

    Continuous and stepwise cystometry were performed through suprapubic catheters in 12 healthy young subjects in order to assess passive viscoelastic variables of the normal human bladder during the collection phase. Elastic contants increased non-linearly with bladder distension. Relative elastic modulus and relaxation time of the bladder wall increased or tended to increase with bladder distension and infusion rate. There was considerable interindividual variation in all variables suggesting that discrimination between normal and abnormal bladder wall viscoelasticity may be difficult in routine clinical practice.

  • 11. Andersson, Staffan
    et al.
    Kronström, A
    Department of Clinical Physiology, Umeå university.
    Hentschel, J
    Department of Clinical Physiology, Umeå university.
    Wall mechanics of the rat bladder. II. Hydrodynamic studies in the frequency domain1988In: Acta Physiologica Scandinavica, ISSN 0001-6772, E-ISSN 1365-201X, Vol. 134, no 4, p. 463-466Article in journal (Refereed)
    Abstract [en]

    The hydrodynamic properties of the urinary bladder in rat were examined by means of very small periodic changes in volume at different frequencies. The elastance increased with increasing frequency of volume changes, indicating the presence of viscoelastic elements. When the bladder was only moderately distended the influence of viscosity was minor. We consider that the rat bladder examined by this technique is an ideal experimental model for assessment of in vivo effects of pharmacological agents on bladder wall tonus. For example, cholinergic treatment showed a 100% increase in elastance and atropine inhibited this effect completely within 3 min.

  • 12. Andersson, Staffan
    et al.
    Kronström, A
    Department of Clinical Physiology, Umeå university.
    Teien, D
    Department of Clinical Physiology, Umeå university.
    Wall mechanics of the rat bladder. I. Hydrodynamic studies in the time domain.1988In: Acta Physiologica Scandinavica, ISSN 0001-6772, E-ISSN 1365-201X, Vol. 4, no 457-461, p. 5-Article in journal (Refereed)
    Abstract [en]

    The hydrodynamic properties of the rat bladder in the collection phase were examined by slow continuous and very fast stepwise cystometry in nine rats. In vivo, the fast volume steps induced a reproducible detrusor contraction (type A) which remained after spinal anaesthesia and anticholinergic treatment, but ceased post-mortally within 1 h. No significant effect of anticholinergic treatment was found on bladder stiffness. The stiffness and relaxation time of the bladder wall increased markedly at large distension. At small and moderate distension, however, the compliances evaluated from continuous and stepwise cystometry were nearly the same, and a linear elastic model of the bladder was applicable. We consider that the rat bladder will be a useful experimental model in further research on viscoelasticity and instability of the bladder wall.

  • 13. Andersson, Staffan
    et al.
    Linderholm, H
    Rinnström, O
    Burlin, L
    A laser Doppler technique for measuring distal blood-pressure: a comparison with conventional strain-gauge technique1986In: Clinical Physiology, ISSN 0144-5979, E-ISSN 1365-2281, Vol. 6, no 4, p. 329-335Article in journal (Refereed)
    Abstract [en]

    Twenty-five patients with peripheral circulatory disorders were examined by laser Doppler and strain-gauge techniques to compare these methods of measuring distal systolic blood-pressure. The correlation coefficients for simultaneous measurement of toe and ankle systolic blood-pressures were high, 0.98 and 0.99 respectively. The correlation coefficient for successive measurements of toe pressure was lower, 0.83, probably because of a variation in blood-pressure with time. The laser Doppler method seems to be more sensitive than the strain-gauge method in the low-pressure range. The laser Doppler probe is easy to attach to most skin surfaces and the laser Doppler technique may be, therefore, an alternative and a complement to the strain-gauge method when the strain-gauge is difficult to use on damaged or ulcerous toes and feet.

  • 14. Andersson, Staffan
    et al.
    Olofsson, BO
    Department of Internal Medicine, University Hospital, Umeå.
    Forsberg, Håkan
    Department of Internal Medicine, University Hospital, Umeå.
    Bjerle, P
    Department of Internal Medicine, University Hospital, Umeå.
    Henriksson, A
    Department of Internal Medicine, University Hospital, Umeå.
    Wedin, I
    Department of Internal Medicine, University Hospital, Umeå.
    Electrocardiographic findings in myotonic dystrophy1988In: Arctic Medical Research, ISSN 0782-226X, Vol. 47, no Suppl 1, p. 420-422Article in journal (Refereed)
  • 15. Andersson, Staffan
    et al.
    Olofsson, BO
    Department of Internal Medicine, University Hospital, Umeå.
    Niklason, U
    Department of Internal Medicine, University Hospital, Umeå.
    Forsberg, Håkan
    Department of Internal Medicine, University Hospital, Umeå.
    Bjerle, P
    Department of Internal Medicine, University Hospital, Umeå.
    Henriksson, A
    Department of Internal Medicine, University Hospital, Umeå.
    Assessment of autonomic nerve function in myotonic dystrophy1990In: Journal of the Autonomic Nervous System, ISSN 0165-1838, E-ISSN 1872-7476, Vol. 29, no 3, p. 187-192Article in journal (Refereed)
    Abstract [en]

    The function of the autonomic nervous system was studied in 23 patients with myotonic dystrophy, from a defined population in northern Sweden with an extremely high prevalence of this disease. Heart rate variability tests showed only minor signs of parasympathetic dysfunction. Blood pressure and plasma noradrenaline measurements in recumbent and upright positions showed no signs of sympathetic neuropathy. Increased plasma levels of noradrenaline was an unexpected finding. Our study does not support the hypothesis that cardiac arrhythmias, orthostatic hypotension, gastrointestinal motility disturbances and urinary bladder dysfunction in myotonic dystrophy are caused by autonomic neuropathy, and we believe that these symptoms should rather be ascribed to a defective function of the target organs

  • 16. Andersson, Staffan
    et al.
    Rönnblom, Anders
    Department of Medicine, Central Hospital, Boden.
    Danielsson, Å
    Department of Medicine, Central Hospital, Boden.
    Mechanisms of diarrhoea in myotonic dystrophy1998In: European Journal of Gastroenterology and Hepathology, ISSN 0954-691X, E-ISSN 1473-5687, Vol. 10, no 7, p. 607-10Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Gastrointestinal (GI) symptoms are common in myotonic dystrophy (MD). Diarrhoea is one of the more disabling of these GI complaints. The mechanisms behind diarrhoea in MD have not previously been investigated systematically. OBJECTIVE: To elucidate the mechanisms behind diarrhoea in MD. METHODS: Twenty patients with MD and suffering from diarrhoea were investigated in order to detect malabsorption (blood tests and faecal fat excretion) and bile acid malabsorption ([75Se]selenahomocholic acid-taurine (SeHCAT) retention) and to study intestinal morphology (duodenal and rectal biopsies). RESULTS: Two patients had deficiency of folic acid and four showed reduced levels of pancreatic isoamylase, but none of them had steatorrhoea. Two out of eight patients had abnormal bile acid breath tests with normal SeHCAT, indicating small bowel bacterial overgrowth and 12 displayed reduced SeHCAT retention. Duodenal biopsies were normal in eight patients and five out of nine rectal biopsies displayed slight inflammation. CONCLUSIONS: A possible mechanism of diarrhoea in MD could be identified in most of the patients. Bile acid malabsorption seems to be a frequent cause and can be treated successfully

  • 17.
    Andersson, Staffan
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Sundström, G
    Njurar och urinvägar2005In: Klinisk fysiologi: med nuklearmedicin och klinisk neurofysiologi, Stockholm: College of Liberal Arts and Sciences, 2005, 2. uppl., p. 292-310Chapter in book (Other (popular science, discussion, etc.))
  • 18.
    Andersson, Staffan
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Tigerman, B
    Kvalitetsundersökning av svenska bredbandsnätet med avseende på datatransmission 12-grupplänkar: Analys av mätmetoder1974Report (Other (popular science, discussion, etc.))
  • 19.
    Andersson, Staffan
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Tigerman, B
    Kvalitetsundersökning av svenska bredbandsnätet med avseende på datatransmission över 12-grupplänkar: Mätmetoder och dataunderlag1974Report (Other (popular science, discussion, etc.))
  • 20. Andersson, Staffan
    et al.
    Österlind, PO
    Department of Clinical Physiology, Umeå university.
    Holmboe, G
    Department of Clinical Physiology, Umeå university.
    Winblad, B
    Department of Clinical Physiology, Umeå university.
    Twenty-four-hour electrocardiography in a healthy elderly population1988In: Gerontology, ISSN 0304-324X, E-ISSN 1423-0003, Vol. 34, no 3, p. 139-144Article in journal (Refereed)
    Abstract [en]

    Twenty-four hour electrocardiography was performed in fifteen 73-year-old and seventeen 82-year-old subjects without known cardiovascular disease. They were selected from a representative population of elderly people. All subjects showed supraventricular premature beats. Supraventricular tachycardia was seen in 63%. Eighty-four percent showed ventricular premature beats (VPBs), and more than two VPB configuration types were seen in 23% of the subjects. Episodes of intermittent atrial flutter and fibrillation, higher-degree atrioventricular blocks and ventricular tachycardia were absent or rare.

  • 21. Axelsson, Karin
    et al.
    Andersson, Staffan
    Välivaara, Britt-Marie
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    Projekt: Omvårdnad - Informations- och kommunikationsteknik2010Other (Other (popular science, discussion, etc.))
    Abstract [sv]

    Upplevelser och erfarenheter av undersökningar i hemmet med hjälp av informations- och kommunikationsteknik beskrivet ur patienters och läkares perspektiv.Projektets övergripande syfte  Syftet med projektet är att belysa upplevelser och erfarenheter av undersökningar i hemmet med hjälp av informations. och kommunikationsteknik.    Kort beskrivning av projektet   I den första studien intervjuades 9 personer som fick vård i hemmet om deras syn på den nya teknik som distriktssköterskorna använde i hemsjukvården för diagnostik och kommunikation. I intervjuerna framkom stor tilltro till denna teknik men den kan inte överlåtas till patienterna själva eller deras anhöriga att sköta.I den andra studien gjordes gruppintervjuer omfattande totalt 17 distriktsläkare med varierande erfarenhet av en ny teknik som prövades i projektform. Uppfattningen om användbarheten av den nya tekniken vid intervjutillfället och i ett framtidsperspektiv varierade stort. Samtliga framhöll vikten av det personliga mötet med patienten som aldrig kan ersättas.I båda studierna användes kvalitativ innehållsanalys för att analysera intervjutexterna.

  • 22.
    Bjerle, P
    et al.
    Department of Internal Medicine, University Hospital, Umeå.
    Andersson, Staffan
    Olofsson, BO
    Department of Internal Medicine, University Hospital, Umeå.
    Forsberg, Håkan
    Department of Internal Medicine, University Hospital, Umeå.
    Henriksson, A
    Department of Internal Medicine, University Hospital, Umeå.
    Wedin, I
    Department of Internal Medicine, University Hospital, Umeå.
    Electrocardiographic findings in myotonic dystrophy1988In: British Heart Journal, ISSN 0007-0769, Vol. 59, no 1, p. 47-52Article in journal (Refereed)
    Abstract [en]

    Sixty five patients with myotonic dystrophy, from a defined population in northern Sweden with an extremely high prevalence of this disease, were examined by electrocardiography. The patients were subdivided into three groups according to the severity of the disease. Abnormal electrocardiograms were found in 6 (35%) patients with mild disease, 12 (50%) patients with moderate disease, and 23 (96%) patients with severe disease. First degree atrioventricular block and left anterior hemiblock were the most commonly encountered abnormalities in patients with mild and moderate disease, whereas atrial fibrillation and flutter, abnormal Q waves, and repolarisation abnormalities were more common in patients with severe disease. This study shows that the heart is often affected by myotonic dystrophy. These effects can be detected by electrocardiography in early and mild forms of the disease. The effect on the heart is progressive and clinically important atrial arrhythmias and electrocardiographic abnormalities which are useful in differential diagnosis are common in severe forms of the disease.

  • 23.
    Engström, Åsa
    et al.
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    Andersson, Staffan
    Söderberg, Siv
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    Experiences of a follow-up visit to an ICU2008In: 3rd EfCCNa Congress and the 27th Aniarti congress: Influencing Critical Care Nursing in Europe 9-11 October 2008, Florence, Italy, European federation of Critical Care Nursing associations , 2008Conference paper (Other academic)
  • 24.
    Engström, Åsa
    et al.
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    Andersson, Staffan
    Söderberg, Siv
    Re-visiting the ICU Experiences of follow-up visits to an ICU after discharge: a qualitative study2008In: Intensive & Critical Care Nursing, ISSN 0964-3397, E-ISSN 1532-4036, Vol. 24, no 4, p. 233-241Article in journal (Refereed)
    Abstract [en]

    The aim of this study is to describe how people who have been critically ill, and their close relatives experience a post-discharge, follow-up visit to the intensive care unit (ICU) that provided the care. There is a lack of studies from such a standpoint. The study design is qualitative. A total of 18 adults participated; nine had been critically ill and nine were close relatives, all made a post-discharge follow-up visit to an ICU in the northern part of Sweden. The study data was collected through personal interviews, conducted after the follow-up visit, using a narrative approach. The data were then subjected to qualitative thematic content analysis which resulted in four themes: receiving strength from returning together; making sense of the critical-illness experience; feeling grateful to have survived and the possibility of improving the care. People who had been critically ill and close relatives felt that returning together was valuable. Meeting the staff, with whom participants felt they had developed a relationship, made it possible for them to express their gratitude for the treatment and nursing care received, and to suggest improvements. The interviews revealed that the follow-up visit was seen as an important way of learning what had happened and why during the period of critical illness.

  • 25. Kronström, A
    et al.
    Andersson, Staffan
    Hydrodynamic model of the urinary bladder derived from stepwise cystometry in the rat1988In: Medical and Biological Engineering and Computing, ISSN 0140-0118, E-ISSN 1741-0444, Vol. 26, no 3, p. 267-270Article in journal (Refereed)
  • 26.
    Leijon-Sundqvist, Katarina
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Lehto, Niklas
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Juntti, Ulla
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Operation, Maintenance and Acoustics. Performance in Cold AB, Luleå.
    Karp, Kjell
    Heart Centre, Clinical Physiology, Department of Surgical and Perioperative Sciences, Umeå University.
    Andersson, Staffan
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Thermal response after cold-water provocation of hands in healthy young men2015In: Thermology International, ISSN 1560-604X, Vol. 25, no 2, p. 48-53Article in journal (Refereed)
    Abstract [en]

    The thermal response in hands provoked by cold water was investigated with infrared thermography. In 26 healthy young men, the response of hand skin temperature to cold water provocation was measured twice on consecutive days. An infrared thermographic camera was used and data were processed in real time. The software divides each hand into 18 predefined regions of interest (ROI). The average temperature in each ROI was stored every 10th second. Baseline hand skin temperature was recorded for two minutes. The bare hands were then immersed for 30 seconds in water at 10°C × 0.5°C and carefully dried. Thereafter, the cooled and final hand skin temperature was measured. The baseline showed a higher average temperature of 0.3°C on day 2 and the 95% limits of agreement (LOA) were - 5.2-5.8, the cooled average temperatures showed no significant difference between the two days (LOA: - 4.8-4.6) and the average final hand skin temperature was 0.8°C higher on day 2 (LOA: - 5.2-6.4). In conclusion, there was variability between the two measurements, small differences in the temperature response to the reaction to cold-water provocation - probably due to Day 1 stress factor.

  • 27.
    Leijon-Sundqvist, Katarina
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Lehto, Niklas
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Juntti, Ulla
    Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Operation, Maintenance and Acoustics.
    Linné, Anders
    Karp, Kjell
    Andersson, Staffan
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Thermal response after cold-water provocation of hands of healthy young men: A test-retest investigation2014Conference paper (Other academic)
  • 28.
    Lundbäck, Bo
    et al.
    Karolinska Institutet.
    Lindberg, Ann
    Sunderby sjukhus, Luleå.
    Lindström, Mai
    Rönmark, Eva
    Norrbottens Läns Landsting.
    Jonsson, A-C
    Jönsson, E
    Larsson, Lars-Gunnar
    Sunderby sjukhus, Luleå.
    Andersson, Staffan
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Sandström, A
    Larsson, K
    Not 15 but 50% of smokers develop COPD?: report from the Obstructive Lung Disease in Northern Sweden Studies2003In: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 97, no 2, p. 115-122Article in journal (Refereed)
  • 29.
    Lundbäck, Bo
    et al.
    Department of Lung Medicine, Central Hospital, Boden.
    Stjernberg, Nils
    National Institute of Occupational Health, Medical Division, Umeå.
    Rosenhall, Leif
    National Institute of Occupational Health, Medical Division, Umeå.
    Jönsson, Elsy
    National Institute of Occupational Health, Medical Division, Umeå.
    Lindström, Mai
    National Institute of Occupational Health, Medical Division, Umeå.
    Andersson, Staffan
    Methacholine reactivity and asthma: Report from the Northern Sweden Obstructive Lung Disease Project1993In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 48, no 2, p. 117-24Article in journal (Refereed)
    Abstract [en]

    Methacholine tests were used in an epidemiologic study of the prevalence of asthma and chronic bronchitis in northern Sweden. Of 6610 subjects in three age groups from eight representative geographic areas in the northernmost province of Sweden, 5698 (86%) completed a postal questionnaire on respiratory symptoms, and 1506 underwent a structured interview and a lung function test. A total of 292 (5%) were diagnosed as having asthma. A subsample of 284 subjects (of 320 invited) classified at the interview as having asthma (n = 98) or as having respiratory symptoms that might be due to asthma but not fulfilling the interview criteria for the diagnosis of asthma (n = 186) underwent a methacholine test. Subjects who, before the interview study, already had a well-defined asthma diagnosis were not invited to the methacholine testing. Of those 98 subjects classified as having asthma, 61% reacted to methacholine doses < or = 4 mg/ml and 79% to doses < or = 8 mg/ml, while the corresponding figures in the symptomatic but nonasthma group were 20% and 34%, respectively. The results show that a carefully performed structured interview accurately diagnoses asthma in epidemiologic studies. The methacholine tests provide important diagnostic information primarily in subjects in whom the medical history is equivocal

  • 30.
    Poso, Tomi
    et al.
    Sunderby Hospital, Department of Anaesthesiolofy & Intensive Care.
    Kesek, Doris
    Umea University, Department of Surgery & Perioperative Science, Department fo Cardiothorac Anaesthesia.
    Winso, Ola
    Umea University, Department of Surgery & Perioperative Science, Department fo Cardiothorac Anaesthesia.
    Andersson, Staffan
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Volatile rapid sequence induction in morbidly obese patients2011In: European Journal of Anaesthesiology, ISSN 0265-0215, E-ISSN 1365-2346, Vol. 28, no 11, p. 781-787Article in journal (Refereed)
    Abstract [en]

    Background and objective The interest in bariatric surgery is growing. Morbidly obese patients have an increased risk of hypoxia and decreased blood pressure during rapid sequence induction (RSI). Alternate RSI methods that provide cardiovascular and respiratory stability are required. With this in mind, we evaluated a method for volatile RSI in morbidly obese patients. Design Observational study. Methods Thirty-four patients with mean BMI 42.4 kg m(-2) undergoing bariatric surgery (morbidly obese group) and 22 patients with mean BMI 25.6 kg m(-2) as a control group were included in the study. Anaesthesia was induced with sevoflurane, propofol, suxamethonium and alfentanil, designed to avoid respiratory and haemodynamic adverse events and to minimise depressing effect on the brain respiratory centre under ongoing RSI. Peripheral oxygen saturation (SpO(2)) and mean arterial blood pressure were registered before and after endotracheal intubation. In addition, two time periods were measured during RSI: spontaneous breathing time (SBT) and apnoea time. Results We found no significant differences between the groups. No periods of desaturation were detected. SpO(2) was 100% before and after endotracheal intubation in all patients. Mean arterial pressure was maintained at a stable level in both groups. Mean SBT and apnoea time were 65.6 and 45.8 s in the morbidly obese group, and 70.7 and 47.7 s in the control group, respectively.

  • 31. Reiz, S
    et al.
    Ahlin, J
    Ahrenfeldt, B
    Andersson, M
    Andersson, Staffan
    Epidural morphine for postoperative pain relief.1981In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 25, no 2, p. 111-114Article in journal (Refereed)
    Abstract [en]

    Thirty-three patients were randomly assigned to two groups to study the analgesic potency, duration of action and side effects of epidural and intramuscular morphine after hip surgery. Two milligrams of preservative-free morphine chloride in 10 ml of normal saline in the epidural space was compared to 10 mg of intramuscularly administered morphine. There was a more rapid onset of action after intramuscular morphine. However, the quality of pain relief was substantially higher and the duration of action markedly longer after epidural morphine. The total dose required in the epidural group was 3.6 mg and in the intramuscular group 41 mg during the 15-h observation period. The side effects of epidural morphine were few and mild, the most embarrassing being urinary retention (20%). Nausea and/or vomiting was less common after epidural morphine (20% versus 55%). Pruritus or respiratory depression which have been reported previously were not encountered. However, it is recommended that preservative-free solution are used to avoid itching and that the patients are monitored, as respiratory depression may occur long after administration of epidural opiate

  • 32.
    Rönnblom, Anders
    et al.
    Uppsala University Hospital.
    Andersson, Staffan
    Hellström, PM
    Danielsson, Å
    Gastric emptying in myotonic dystrophy2002In: European Journal of Clinical Investigation, ISSN 0014-2972, E-ISSN 1365-2362, Vol. 32, no 8, p. 570-4Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Gastrointestinal symptoms are common and important for the quality of life in patients with myotonic dystrophy (MD). Gastric emptying was studied in patients with MD who suffered from symptoms suggesting slow gastric emptying and the effect of prokinetic treatment was evaluated. METHODS: Gastric emptying was studied in 10 patients with MD who were suffering from nausea, early satiety, bloating, regurgitation, vomiting, or abdominal pain using a (99)Tc-labelled test meal, and was compared with gastric emptying in a group of healthy controls. The patients were subsequently treated with erythromycin and their gastrointestinal symptoms were recorded and the gastric emptying test was repeated. RESULTS: Patients with MD had a significantly longer gastric lag phase (46.1 +/- 4.3 vs. 31.9 +/- 4.0 min, P = 0.03), a slower emptying phase (7.1 +/- 0.9 vs. 10.2 +/- 0.9 kJ min(-1), P = 0.02) and a longer half-emptying time, T50 (141.7 +/- 10.5 vs. 98.6 +/- 8.7 min, P = 0.01) than a matched control group. Erythromycin did not stimulate the gastric emptying rate. The effect on gastrointestinal symptoms was modest, except for a reduction of diarrhoea. CONCLUSIONS: Patients with MD suffering from nausea, vomiting and early satiety, displayed a slow gastric emptying. Treatment with erythromycin had only moderate effect on gastric emptying or gastric symptoms, but reduced diarrhoea in a majority of the patients.

  • 33.
    Wisten, Aase
    et al.
    Department of Internal Medicine, Sunderby Hospital, Lulea.
    Andersson, Staffan
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Forsberg, Håkan
    Department of Internal Medicine, Sunderby Hospital, Lulea.
    Krantz, P
    Messner, Torbjörn
    Department of Internal Medicine, Sunderby Hospital, Lulea.
    Sudden cardiac death in the young in Sweden: electrocardiogram in relation to forensic diagnosis2004In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 255, no 2, p. 213-220Article in journal (Refereed)
    Abstract [en]

    OBJECTIVES: To study electrocardiogram (ECG) in relation to forensic diagnosis in young persons who suffered a sudden cardiac death (SCD) in Sweden during 1992-99. DESIGN: A register study of a national database of forensic medicine in Sweden, selecting all cases of SCD 15-35 years of age. In this group, 12-lead ECGs and clinical data were searched for in military conscription and medical records. The ECGs were re-analysed and classified according to the Minnesota code criteria. SETTING: The whole nation of Sweden. SUBJECTS: Sudden cardiac death victims (66 individuals), 15-35 years of age, where it was possible to obtain an ECG recording. RESULTS: We observed major or minor ECG abnormalities in 82% of the subjects. The most common changes were T wave abnormalities (35%), ST segment changes (32%) and conduction defects (20%). The ECGs were evaluated as pathological in 50% of the cases, more often in arrhythmogenic right ventricular cardiomyopathy (88%) and hypertrophic cardiomyopathy (82%). Cardiac-related symptoms were seen in 76% of the total group and there was a family history of a similar cardiac condition in 18%. CONCLUSIONS: Pathological ECGs were common in young SCD victims, in spite of being taken many years before death. An ECG could help identify prospective victims of SCD, and should always be taken in cases with possible cardiac-related symptoms or a family history of SCD. The pathological ECGs were often found in connection with routine screening at military enlistment for men, which raises the question of a routine screening in the young, including women

  • 34.
    Wälivaara, Britt-Marie
    et al.
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    Andersson, Staffan
    Axelsson, Karin
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    General practitioners' reasoning about using mobile distance-spanning technology in home care and in nursing home care2011In: Scandinavian Journal of Caring Sciences, ISSN 0283-9318, E-ISSN 1471-6712, Vol. 25, no 1, p. 117-125Article in journal (Refereed)
    Abstract [en]

    The trend for health care and nursing care turns from hospital to health care and nursing care at home. Studies have shown that health care professionals have no access to patient records in home and nursing home settings. Technological development creates opportunities for a host of mobile technology solutions. The aim of this study was to describe the reasoning among general practitioners (GPs) about the use of mobile distance-spanning technology (MDST) in care at home and in nursing homes. Seventeen GPs were divided in five groups for a group interview. The interviews were tape-recorded and transcribed verbatim. The qualitative content analysis resulted in four areas about the MDST, MDST has an impact on GPs' work, the nurses' profession, and the patient and the family, with nine adherent categories. The findings were interpreted and formulated in the theme: MDST should be used with caution. The results show quite a few expressions about the MDST as useful and valuable in health care at home and in nursing home settings; however, in every category, there were text that we interpreted as caution when using the MDST. The MDST cannot be used in all situations and cannot replace human meetings in health care and nursing care at home and in nursing homes. The MDST should primarily be a tool for the profession, and understanding the professions' reasoning about technology use in health care at home and in nursing home settings must be the base for implementing MDST.

  • 35.
    Wälivaara, Britt-Marie
    et al.
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    Andersson, Staffan
    Axelsson, Karin
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    The importance of human meetings in health care at home with mobile distance-spanning technology2010In: Journal of Clinical Nursing, ISSN 0962-1067, E-ISSN 1365-2702, Vol. 19, no Suppl. 1, p. 91-Article in journal (Other academic)
    Abstract [en]

    Introduction: New solutions could be a challenge for both the persons in need of health care at home and the health care professions when the person's individual needs in health care at home have to be met. The mobile distances-spanning technology (MDST) could come into use to support the health care at home. Before implementing the MDST the voices of persons in need of health care at home need to be heard about the use of MDST. Methods and Materials: The aim was to describe views and experiences about the use of MDST in health care at home from the perspectives of persons in need of health care at home. The persons were living in ordinary homes and all had experiences of MDST when district nurses were caring for them at home. Persons in need of health care at home (n=9) participated in individual qualitative research interviews for data collection. Qualitative content analysis was used for data analysis. Results: Participants put health care at home in the first place and the MDST was put in the second place. The importance of human meetings was put forwards. The results indicate in different ways opportunities, possibilities and risks with using MDSTs. When the MDST was used, it was important to have established a relationship and trust to the district nurses and the general practitioners, and to know them and to be known by them. The participants expressed that the health care professionals need to see the person behind the technology. Conclusion: Human meetings can never be excluded in health care at home even when a virtual meeting for some issues is relevant. The MDST can never capture or replace the human meetings but human meetings and virtual meetings can be used as complement to each other.

  • 36.
    Wälivaara, Britt-Marie
    et al.
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    Andersson, Staffan
    Axelsson, Karin
    The mobile distance-spanning technology in health care at home2010In: Journal of Clinical Nursing, ISSN 0962-1067, E-ISSN 1365-2702, Vol. 19, no Suppl. 1, p. 92-Article in journal (Other academic)
    Abstract [en]

    Introduction: Health care at home could be a challenge for both the persons in need of health care at home and the health care professions when the person's individual needs in health care at home have to be met. There is a need for different technical solutions in order to create opportunities for persons in need of health care to stay in their own homes and get health care. The mobile distances-spanning technology (MDST) could come into use to support the health care at home for the future. Methods and Materials: The aim of this presentation is to describe the usefulness of MDST in health care at home. During a project MDST have been tested as an addition in health care at home. The district nurses used 11 different mobile equipments in home care. During the home visits they filled out a form (n=154) about which equipment they used when caring for persons in home care. Results: The district nurses did totally 184 home visits and in 154 cases they used the equipments during the test period. The most frequently used equipment was the mobile computer with access to the patient record (73%) and the access to the patient record was reported as useful at home. The district nurses noted importance to use the bladder scanner even if it was not used so often (11%). The digital camera was used (8%) and was reported as complicated but useful when documenting the healing process of wounds. When the electronic stethoscope was used (7%) some reported a disturbing sound that hampered the assessment. Conclusion: There are several equipments that could be useful and it is important to test and identify the equipments that are most suitable for use in home care.

  • 37.
    Wälivaara, Britt-Marie
    et al.
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    Andersson, Staffan
    Luleå University of Technology, Department of Health Sciences.
    Axelsson, Karin
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    Trust and relationship when using mobile distance-spanning technology in healthcare at home2011In: e-health and nursing: How Can E-Health Promote Patient Safety? : ACENDIO 2011, 8th European Conference of ACENDIO / [ed] Fintan Sheerin, Dublin: Association for Common European Nursing Diagnoses, Interventions and Outcomes , 2011, p. 344-350Conference paper (Refereed)
  • 38.
    Wälivaara, Britt-Marie
    et al.
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    Andersson, Staffan
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Axelsson, Karin
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    Views on technology among people in need of health care at home2009In: International Journal of Circumpolar Health, ISSN 1239-9736, E-ISSN 2242-3982, Vol. 68, no 2, p. 158-169Article in journal (Refereed)
    Abstract [en]

    Objectives. The aim of this study was to describe how people in need of health care at home view technology.Study design. A qualitative approach was used based on qualitative interviews, followed by qualitative content analysis.Methods. District nurses (DNs) from 4 health care centres in Northern Sweden had access to different kinds of distance-spanning technology with mobile devices and who used it in their health care at home. Persons in whose home the technology was being used were asked to participate in an interview. The interviewed persons were selected consecutively. Results. The results fall into 2 categories: (1) The well-known technology at hospital is new at home, (2) the new technology opens up possibilities but it also has limitations, with seven adherent subcategories.Conclusions. The participants viewed the technology at home as something good and as something that could open up possibilities. At the same time, they placed the use of the technology in the hands of the staff which indicates some degree of dissociation from the technology. The importance of personal meetings between patient and caregiver was very clearly stressed even when distance meetings could be performed and accepted. The participants expressed immense trust in the nursing staff and considered them responsible for the new technology at home.

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