Tire pressure monitoring system (TPMS) has a critical role in safeguarding vehicle safety by monitoring tire pressure levels. Keeping the accurate tire pressure is necessary for confirming comfortable driving and safety, and improving fuel consumption. Tire problems can result from various factors, such as road surface conditions, weather changes, and driving activities, emphasizing the importance of systematic tire checks. This study presents a novel method for tire condition monitoring using weightless neural networks (WNN), which mimic neural processes using random-access memory (RAM) components, supporting fast and precise training. Wilkes, Stonham, and Aleksander Recognition Device (WiSARD), a type of WNN, stands out for its capability in classification and pattern recognition, gaining from its ability to avoid repetitive training and residual formation. For vibration data acquisition from tires, cost-effective micro-electro-mechanical system (MEMS) sensors are employed, offering a more economical solution than piezoelectric sensors. This approach yields a variety of features, such as autoregressive moving average (ARMA), statistical and histogram features. The J48 decision tree algorithm plays a critical role in selecting essential features for classification, which are subsequently divided into training and testing sets, crucial for assessing the WiSARD classifier’s efficacy. Hyperparameter optimization of the WNN leads to improved classification accuracy and shorter computation times. In practical tests, the WiSARD classifier, when optimally configured, achieved an impressive 97.92% accuracy with histogram features in only 0.008 seconds, showcasing the capability of WNN to enhance tire technology and the accuracy and efficiency of tire monitoring and maintenance.