Change search
Refine search result
1234567 101 - 150 of 546
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the Create feeds function.
  • 101. Erlandsson, Maja
    et al.
    Wiklund, Maria Lennernäs
    Department of Medical Sciences, Nutrition, Uppsala University.
    Månsson, Helena Lindmark
    Mjölk & mejeriprodukter: viktiga näringskällor2005In: Vaar Foeda, ISSN 0042-2657, Vol. 57, no 1, p. 30-35Article in journal (Other (popular science, discussion, etc.))
  • 102.
    Ersson, Bernt
    et al.
    Allmänläkare, Gävle.
    Aurell, Inger
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Billsen, Mats
    Ortopediska kliniken Hässleolm-Kristianstad.
    Dobrescu, Tudor
    Tudorkliniken, Halmstad.
    Dobrescu, Daniela
    Landstingshälsan, Halmstad.
    Flodin, Marianne
    Värmdö Primärvård.
    Pettersson-Hanning, Jan
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Henriksson, Anders
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Holmberg, Göran
    Jensen, Jörn
    Sjukhuset Varberg, Röntgenkliniken.
    Ludwig, Bernd
    Landskrona Läkargrupp.
    Magnusson, Ulla
    Möller, Agneta
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Osteoporos: DXL-hälmätare använd med förstånd räcker långt för klinisk användning2003In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 100, no 3, p. 156-157Article in journal (Other academic)
  • 103.
    Eshuis, Rienk
    et al.
    St. Antonius Hospital, Department of Orthopedic Surgery, Nieuwegein.
    Lentjes, Gijsbertus Wilhelmus
    St. Antonius Hospital, Department of Orthopedic Surgery, Nieuwegein.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Wolterbeek, Nienke
    St. Antonius Hospital, Department of Orthopedic Surgery, Nieuwegein.
    Veen, Maurits Remmelt
    St. Antonius Hospital, Department of Orthopedic Surgery, Nieuwegein.
    Dutch Translation and Cross-cultural Adaption of the Lysholm Score and Tegner Activity Scale for Patients With Anterior Cruciate Ligament Injuries2016In: Journal of Orthopaedic and Sports Physical Therapy, ISSN 0190-6011, E-ISSN 1938-1344, Vol. 46, no 11, p. 976-983Article in journal (Refereed)
    Abstract [en]

    Study Design Clinical measurement. Background The Lysholm score and Tegner Activity Scale are frequently used patient-reported instruments to determine the functional status and activity level after anterior cruciate ligament (ACL) reconstruction. Objectives To translate and cross-culturally adapt the Lysholm score and Tegner Activity Scale for use in the Dutch population and to evaluate reliability and validity of these questionnaires in individuals after ACL reconstruction. Methods The translation and adaptation was conducted in several steps according to the guidelines in the literature. The measurement properties of the Lysholm score and Tegner Activity Scale (internal consistency, construct validity, and floor and ceiling effects) were tested in 96 patients. Reproducibility was tested in 69 patients, for patient with anterior cruciate ligament injuries. On the first occasion, the International Knee Documentation Committee (IKDC) and RAND-36 item Health Survey (RAND-36) were also administered. Results The Lysholm score and Tegner Activity Scale showed good test-retest reliability between repeated measures (respectively ICC 0.93 and 0.97). Internal consistency was reasonable to good (Cronbach's α=0.70-0.83). The Lysholm score had a very strong correlation with the IKDC (r= 0.83, p<0.01) and moderate correlation with the RAND-36 (r=0.55, p<0.01). The Tegner Activity Scale had a moderate correlation with both IKDC and the RAND-36 (r= 0.42 p<0.01 respectively r= 0.48 p<0.01). Conclusion This study demonstrated acceptable psychometric performances for the Lysholm score and the Tegner scale as outcome measures for Dutch patients after ACL reconstruction. J Orthop Sports Phys Ther, Epub 28 Sep 2016. doi:10.2519/jospt.2016.6566.

  • 104.
    Forsberg, Hanna
    et al.
    Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden.
    Carlerby, Heidi
    Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden.
    Nordstrand, Annika
    Director of the Public Health Center, Region Norrbotten, Luleå, Sweden.
    Risberg, Anitha
    Luleå University of Technology, Department of Health Sciences, Health and Rehabilitation.
    Kostenius, Catrine
    Luleå University of Technology, Department of Health Sciences, Health and Rehabilitation.
    Positive self-reported health might be an important determinant of student's experiences of high school in northern Sweden2019In: International Journal of Circumpolar Health, ISSN 1239-9736, E-ISSN 2242-3982, Vol. 78, no 1, article id 1598758Article in journal (Refereed)
    Abstract [en]

    There is a need for more knowledge about positive health determinants in the school setting. The overall aim of this study was to analyse if positive self-reported health is associated with experiences of school among high-school students. Data originated from the health dialogue questionnaire answered by students in grade 1 of high school. A total of 5035 students participated from the academic years 2013 to 2016. Logistic regression with positive odds ratio (POR) was used to analyse associations between positive self-reported health and school experiences. There was an association between positive self-reported health and school experiences among students. Positive mental health was the strongest predictor for positive school experiences. To frequently participate in Physical Education, have a positive body image and satisfactory sleep nearly doubled the students' odds for positive school experiences. The results also revealed gender differences; boys more often reported positive experiences of school and positive health than girls. Positive self-reported health is associated with positive experiences of school, particularly mental health. Moreover, these findings have significant implications for how students experience school and demonstrate the importance of including health-promoting interventions in systemic school improvement, meeting both girls' and boys' needs.

  • 105.
    Fritz, Hans F.
    et al.
    Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile.
    Ortiz, Andrea C.
    Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile.
    Velaga, Sitaram
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Morales, Javier O.
    Luleå University of Technology, Department of Health Sciences, Medical Science. Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile.
    Preparation of a novel lipid-core micelle using a low-energy emulsification method2018In: Drug Delivery and Translational Research, ISSN 2190-393X, Vol. 8, no 6, p. 1807-1814Article in journal (Refereed)
    Abstract [en]

    High-energy methods for the manufacturing of nanomedicines are widely used; however, interest in low-energy methods is increasing due to their simplicity, better control over the process, and energy-saving characteristics during upscaling. Here, we developed a novel lipid-core micelle (LCM) as a nanocarrier to encapsulate a poorly water-soluble drug, nifedipine (NFD), by hot-melt emulsification, a low-energy method. LCMs are self-assembling colloidal particles composed of a hydrophobic core and a hydrophilic shell. Hybrid materials, such as Gelucire 44/14, are thus excellent candidates for their preparation. We characterized the obtained nanocarriers for their colloidal properties, drug loading and encapsulation efficiency, liquid state, stability, and drug release. The low-energy method hot-melt emulsification was successfully adapted for the manufacturing of small and narrowly dispersed LCMs. The obtained LCMs had a small average size of ~ 11 nm and a narrow polydispersity index (PDI) of 0.228. These nanocarriers were able to increase the amount of NFD dispersible in water more than 700-fold. Due to their sustained drug release profile and the PEGylation of Gelucire 44/14, these nanocarriers represent an excellent starting point for the development of drug delivery systems designed for long circulation times and passive targeting.

  • 106.
    Gahnström-Strandqvist, Kitty
    et al.
    Karolinska Institutet, Neurotec, Division of Occupational Therapy.
    Liukko, Anneli
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Tham, Kerstin
    Karolinska Institutet, Neurotec, Division of Occupational Therapy.
    The meaning of the working cooperative for persons with long-term mental illness: A phenomenological study2003In: American Journal of Occupational Therapy, ISSN 0272-9490, E-ISSN 1943-7676, Vol. 57, no 3, p. 262-272Article in journal (Refereed)
    Abstract [en]

    The objective of this phenomenological study was to understand the meanings of the lived experiences of persons with long-term mental illness at a social working cooperative. Eighteen participants were interviewed either two or three times while participating in a working cooperative in a community psychosocial rehabilitation program. Data were analyzed and interpreted using the Empirical, Phenomenological, Psychological (EPP) method (Karlsson, 1993). The findings revealed a meaning-structure consisting of one main constituent that characterized the cooperative as a normalizing life-world. Three phases contributed to the normalization process. In the first phase the participants experienced a shift from an unsatisfying occupational context to an enriching occupational life-world. In the second phase participants had the possibility to satisfy some of their occupational and social needs. During this phase, experiences of being productive and needed, commitment to others, development of their skills, and competence in work tasks and social activities were expressed. In the third phase, the meaning of the cooperative changed for some participants, who expressed this through their readiness to leave and take a further step into the life-world outside the cooperative.

  • 107.
    Gardelli, Åsa
    et al.
    Luleå University of Technology, Department of Arts, Communication and Education, Education, Language, and Teaching.
    Backman, Ylva
    Luleå University of Technology, Department of Arts, Communication and Education, Education, Language, and Teaching.
    Gardelli, Teodor
    Luleå University of Technology, Department of Arts, Communication and Education, Education, Language, and Teaching.
    Gardelli, Viktor
    Luleå University of Technology, Department of Arts, Communication and Education, Education, Language, and Teaching.
    Jacobsson, Lars
    Luleå University of Technology, Department of Health Sciences, Health and Rehabilitation. Luleå University of Technology, Department of Health Sciences, Medical Science.
    Strömberg, Caroline
    Luleå University of Technology, Department of Business Administration, Technology and Social Sciences, Social Sciences.
    Utbildning för delaktighet – att filosofera tillbaka ett "nytt" liv efter förvärvad hjärnskada2018In: Resultatdialog 2018, Stockholm: Vetenskapsrådet , 2018, p. 49-52Chapter in book (Other academic)
  • 108.
    Gavini, Elisabetta
    et al.
    Department of Chemistry and Pharmacy, University of Sassari.
    Rassu, Giovanna
    Department of Chemistry and Pharmacy, University of Sassari.
    Ferraro, Luca
    Department of Experimental and Clinical Medicine, Pharmacology Section, University of Ferrara.
    Beggiato, Sarah
    Department of Experimental and Clinical Medicine, Pharmacology Section, University of Ferrara.
    Alhalaweh, Amjad
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Velaga, Sitaram
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Marchetti, Nichola
    Department of Chemistry, University of Ferrara.
    Bandiera, Pasquale
    Department of Biomedical Sciences, University of Sassari.
    Giunchedi, Paolo
    Department of Chemistry and Pharmacy, University of Sassari.
    Dalpiaz, Alessandro
    Department of Pharmaceutical Sciences, University of Ferrara.
    Influence of polymeric microcarriers on the in-vivo intranasal uptake of an anti-migraine drug for brain targeting2013In: European journal of pharmaceutics and biopharmaceutics, ISSN 0939-6411, E-ISSN 1873-3441, Vol. 83, no 2, p. 174-183Article in journal (Refereed)
    Abstract [en]

    The objective of this study was to investigate the effect of polymeric microcarriers on the in-vivo intranasal uptake of an anti-migraine drug for brain targeting. Mucoadhesive powder formulations consisted of antimigraine drug, zolmitriptan, and chitosans (various molecular weights and types) or hydroxypropyl methylcellulose (HPMC). Their suitability for nasal administration was evaluated by in-vitro and ex-vivo mucoadhesion and permeation tests. The formulations based on chitosan glutamate (CG) or HPMC were tested in-vivo because they showed good mucoadhesive properties and altered the permeation rate of the drug. The in-vivo results from intravenous infusion and nasal aqueous suspension of the drug or nasal particulate powders were compared. The plasmatic AUC values obtained within 8 h following intravenous administration appeared about three times higher than those obtained by nasal administration, independent of the formulations. Zolmitriptan concentrations in the cerebrospinal fluid obtained from nasal and intravenous administrations were respectively 30 and 90 times lower than the concentrations of the drug in the blood. Thus, nasal administration potentiated the central zolmitriptan activity allowing a reduction of the drug peripheral levels, with respect to the intravenous administration. Among nasally administered formulations, CG microparticles showed the highest efficacy in promoting the central uptake of zolmitriptan within 1 h.

  • 109.
    Ghaye, Tony
    et al.
    Reflective Learning-UK, Maisemore.
    Melander-Wikman, Anita
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Kisare, Moni
    East African Support Unit for NGOs, Arusha.
    Chambers, Philip
    Reflective Learning-UK, Maisemore.
    Bergmark, Ulrika
    Luleå University of Technology, Department of Arts, Communication and Education, Education, Language, and Teaching.
    Kostenius, Catrine
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Lillyman, Sue
    Faculty of Health, Birmingham City University.
    Participatory and appreciative action and reflection (PAAR): democratizing reflective practices2008In: Reflective Practice, ISSN 1462-3943, E-ISSN 1470-1103, Vol. 9, no 4, p. 361-397Article in journal (Refereed)
    Abstract [en]

    The paper introduces a new approach to reflecting and acting called participatory and appreciative action and reflection (PAAR). It explores its potential to enable individuals and groups to move forward, to improve their working practices and lives in particular communities and contexts. The paper situates PAAR in the historical context of participatory and action methodologies and reflective learning. It suggests that using PAAR requires four strategic ‘turns'. By turn we mean a change in direction from one way of thinking and practising to another. The four turns are: (i) away from a preoccupation with changing behaviours in order to solve problems, with ‘fixing' things and an engagement in deficit-based discourses, towards the development of appreciative insight, understanding the root causes of success and sustaining strengths-based discourses in order to amplify those things that will help build a better future from the positive present; (ii) away from self-learning (individualism and isolation) and towards collective learning through interconnectedness, appreciative knowledge sharing and the use of new forms of communications technology which enable simultaneous action in dispersed geopolitical spaces; (iii) away from one way of knowing and one perspective on truth to an acceptance of more pluralistic view of ways of knowing, of understanding human experience and putting this knowing to good use; (iv) away from reflective cycles and spirals and towards the use of a reflective learning (r-learning) framework comprising four mutually supportive processes. They are those of developing an appreciative ‘gaze', of reframing experience, of building practical wisdom and of achieving and moving forward.

  • 110.
    Gillberg, M.
    et al.
    Karolinska Institutet.
    Pernler, H.
    Karolinska Institutet.
    Nordlund, G.
    Wiklund, Maria Lennernäs
    Swedish Dairy Association.
    Norberg, H.
    Longitudinal changes in the sleep habits of Swedish adolescents2006In: Journal of Sleep Research, ISSN 0962-1105, E-ISSN 1365-2869, Vol. 15, no Suppl. 1, p. 83-, article id P047Article in journal (Refereed)
  • 111.
    Graaf, Cees De
    et al.
    Department of Human Nutrition, Wageningen Agricultural University.
    Gaag, Monique A. Van Der
    Department of Human Nutrition, Wageningen Agricultural University.
    Kafatos, Anthony George
    School of Health Sciences, University of Crete.
    Wiklund, Maria Lennernäs
    Langvagen 35, S-756 52, Uppsala.
    Kearney, John M.
    Institute of European Food Studies, Trinity College, Dublin.
    Stages of dietary change among nationally-representative samples of adults in the European Union1997In: European Journal of Clinical Nutrition, ISSN 0954-3007, E-ISSN 1476-5640, Vol. 51, no Suppl. 2, p. S47-S56Article in journal (Refereed)
    Abstract [en]

    Objective: To investigate the distribution across the different stages of change for each of the 15 participating European countries, and the effect of socio-demographic variables such as sex and education on this distribution. Also to assess the relationships between stages of change and influences of food choice, and other variables. Design: A cross-sectional study in which quota-controlled, nationally-representative samples of approximately 1000 adults from each country completed a face-to-face interview-assisted questionnaire. Setting: The survey was conducted between October 1995 and February 1996 in the 15 member states of the European Union. Subjects: 14,331 subjects (aged 15 y upwards) completed the questionnaire. Data were weighted by population size for each country and by sex, age and regional distribution within each member state. Subjects were divided into five different categories according to their attitudes towards 'changing their eating habits in order to eat healthier': (1) Precontemplation; do not consider any changes, (2) Contemplation; consider changes, (3) Decision; make plans to change, (4) Action; carry out the changes, and (5) Maintenance; maintained changes for more than six months. Results: 52% of the subjects were in the precontemplation stage, whereas 31% of the subjects were in the maintenance stage. Two, one, and seven percent of subjects were in the contemplation, decision and action stage, respectively. In the Mediterranean countries, and in Germany, there were more people (55-64%) in the precontemplation stage, whereas in the Scandinavian countries there were less people in precontemplation stage (20-38%). The opposite was true for the maintenance stage, whereas women and people with a higher education level tended to be more in the maintenance stage. With respect to influences on food choice, subjects in precontemplation stage found that taste was more important, whereas people in maintenance stage found that health was more important. Conclusions: The stages of change model makes a useful distinction between people with different attitudes towards nutrition and health. Nutrition education can benefit from this distinction.

  • 112.
    Gundampati, Ravi Kumar
    et al.
    Molecular Biology Unit, Institute of Medical Sciences, Banaras Hindu University, Varanasi.
    Sahu, Shraddha
    School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi.
    Srivastava, Avinash Kumar
    School of Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi.
    Chandrasekaran, Sambamurthy
    Department of Animal Sciences, University of Hyderabad.
    Rao Vuddanda, Parameswara
    Department of Pharmaceutics, Indian Institute of Technology (BHU), Varanasi.
    Pandey, Rajesh Kumar
    Molecular Biology Unit, Institute of Medical Sciences, Banaras Hindu University, Varanasi.
    Maurya, Radheshyam P.
    Department of Animal Sciences, University of Hyderabad.
    Singh, Sanjay Kumar
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh.
    Jagannadham, Medicherla Venkata
    Molecular Biology Unit, Institute of Medical Sciences, Banaras Hindu University, Varanasi.
    In silico and in vitro studies: Tryparedoxin Peroxidase inhibitor activity of methotrexate for antileishmanial activity2013In: American Journal of Infectous Diseses, ISSN 1553-6203, Vol. 9, no 4, p. 117-129Article in journal (Refereed)
    Abstract [en]

    In order to understand the mechanism of molecular interactions at the active site of Tryparedoxin Peroxidase (Try P), homology modeling and docking studies were performed. We generated a Three-Dimensional (3D) model of target protein based on the Crystal structure of Leishmania Major Try PI (PDB ID: 3TUE) using modeler software. Docking analysis was carried out to study the effects of methotrexate on Tryparedoxin Peroxidase (Try P). Inhibition of the Tryparedoxin peroxidase interaction has become a new therapeutic strategy in treating leishmaniasis. Docking analysis was carried out to study the effects of methotrexate on Tryparedoxin Peroxidase (TryP). Tryparedoxin peroxidase of Trypanosomatidae family functions as antioxidant through their peroxidase and peroxynitrite reductase activities. The theoretical docking study, conducted on a sample previously reported for anti-cancer properties of Methotrexate at the binding site of 3D models of Tryparedoxin Peroxidase of Leishmania braziliensis (L. braziliensis Try P) examine interaction energy. Our studies indicate that Methotrexate displays potent activity against Try P with lowest binding energy and RMSD values to be -14.5879 Kcal/Mol and 2.0 A. The results of the present study clearly demonstrated the Tryparedoxin Peroxidase inhibitory activity by methotrexate in in silico docking analysis and in vitro assay which contributes towards understanding the mechanism of antileishmanial activity.

  • 113.
    Gustavsson, Linda
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science. Department of Anaesthesia, Central Operation Ward, Sunderby Hospital.
    Nyström, Cecilia
    Intensive Care Unit 57, Sunderby Hospital.
    Vikman, Irene
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Engström, Åsa
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    Sore throat and pressure differences in ventilation in women after intubation with an endotrachealtube size 6,5 or 7,02013Conference paper (Other academic)
  • 114.
    Gustavsson, Linda
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science. Department of Anaesthesia, Central Operation Ward, Sunderby Hospital.
    Vikman, Irene
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Nyström, Cecilia
    Intensive Care Unit 57, Sunderby Hospital.
    Engström, Åsa
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    Sore throat in women after intubation with 6.5 or 7.0 mm endotracheal tube: a quantitative study2014In: Intensive & Critical Care Nursing, ISSN 0964-3397, E-ISSN 1532-4036, Vol. 30, no 6, p. 318-324Article in journal (Refereed)
    Abstract [en]

    Background: Women experience more sore throats than men after endotracheal intubation.Aim: The aim of this study was to investigate the incidence of self-rated sore throat immediately,and 2—4 hours postoperatively, in women after elective gynaecological surgery under generalanaesthesia using an endotracheal tube (ETT) size 6.5 or 7.0 mm in inner diameter.Method: Eighty-two female participants who had undergone elective gynaecological surgeryparticipated, 44 and 38 were intubated with size 6.5 mm ETT and 7.0 mm ETT respectively.They estimated the occurrence of sore throat preoperatively and postoperatively, according toa 4-point Likert scale. Statistical data were analysed using the Package for Social Science (SPSS)19.Results: Sore throat was present in 29.5% of participants who were intubated with size 6.5 mmETT immediately postoperatively and in 39.5% of those who were intubated with size 7.0 mmETT.Conclusion: Nurses specialising in the supervision of daily care specific to the intubated patientshould note and alleviate sore throat as part of their nursing care.

  • 115.
    Hedman, Linnea
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    Aktivitet: Riskfaktorer för incidens av astma under tonåren2012Conference paper (Other (popular science, discussion, etc.))
  • 116.
    Hedman, Linnea
    et al.
    Luleå University of Technology, Department of Health Sciences, Nursing Care. he Obstructive Lung Disease in Northern Sweden Unit, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden.
    Backman, Helena
    The Obstructive Lung Disease in Northern Sweden Unit, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden.
    Stridsman, Caroline
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    Bosson, Jenny A.
    Division of Respiratory Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
    Lundbäck, Magnus
    Karolinska Institutet, Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd University Hospital, Stockholm, Sweden.
    Lindberg, Anne
    The Obstructive Lung Disease in Northern Sweden Unit, Division of Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
    Rönmark, Eva
    The Obstructive Lung Disease in Northern Sweden Unit, Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden.
    Ekerljung, Linda
    Krefting Research Center, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Association of Electronic Cigarette Use With Smoking Habits, Demographic Factors, and Respiratory Symptoms2018In: JAMA Network Open, E-ISSN 2574-3805, Vol. 1, no 3, article id e180789Article in journal (Refereed)
    Abstract [en]

    Importance  Increases in total knee arthroplasty (TKA) utilization rates suggest that its indications have been expanded to include patients with less severe symptoms. A recent study challenged the cost-effectiveness of TKA in this group of patients.

    Objective  To determine the association of the 36-Item Short Form Health Survey physical component summary score (SF-36 PCS) with patient satisfaction 2 years after TKA.

    Design, Setting, and Participants  This cohort study reviewed registry data from 2 years of follow-up of patients who underwent unilateral TKA from January 1, 2010, to December 31, 2014, at a single-center tertiary institution in Singapore. Data were acquired on April 27, 2017, and analyzed from August 15, 2017, to December 22, 2017.

    Main Outcomes and Measures  Patient satisfaction and SF-36 PCS. Preoperative disability and postoperative function as measured by the SF-36 PCS were correlated with Δ (2-year end point score minus baseline score) and patient satisfaction, scored on a 6-point Likert scale, with lower scores indicating greater satisfaction.

    Results  Of the 6659 patients, 5234 (78.6%) were female and 5753 (86.4%) were of Chinese ethnicity. Mean (SD) age was 67.0 (7.7) years, and mean (SD) body mass index (calculated as weight in kilograms divided by height in meters squared) was 27.7 (4.6). At 2-year follow-up, the mean (SD) SF-36 PCS score improved from 32.2 (10.1) to 48.2 (9.5) (P < .001). There were 1680 patients (25.2%) who described their satisfaction as excellent, 2574 (38.7%) very good, 1879 (28.2%) good, 382 (5.7%) fair, 96 (1.4%) poor, and 48 (0.7%) terrible. The minimal clinically important difference (change in SF-36 PCS of 10 from baseline) was met in 4515 patients (67.8%), and overall satisfaction was 97.8% (6515 patients). Covariance analysis showed significantly higher satisfaction in patients with preoperative scores of 40 to less than 50. Patients who were unlikely to meet the minimal clinically important difference compared with those who were likely to meet it (SF-36 PCS of ≥42.1 vs <42.1) had significantly higher 2-year satisfaction (mean [SD], 2.15 [0.9] vs 2.23 [1.0]; P = .009).

    Conclusions and Relevance  The findings suggest that a general health score, such as SF-36, is not associated with patient satisfaction 2 years after TKA. Functional assessment, preoperative counseling, and modification of expectations appear to remain vital before TKA.

  • 117.
    Hedman, Linnea
    et al.
    Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, The OLIN Unit, Umeå University.
    Bjerg, Anders
    OLIN studies, Norrbotten County Council.
    Lundbäck, Bo
    Department of Internal Medicine and Clinical Nutrition, Krefting Research Centre, University of Gothenburg.
    Rönmark, Eva
    Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, The OLIN Unit, Umeå University.
    Conventional epidemiology underestimates the incidence of asthma and wheeze – a longitudinal population-based study among teenagers2012In: Clinical and Translational Allergy, ISSN 2045-7022, E-ISSN 2045-7022, Vol. 2Article in journal (Refereed)
  • 118.
    Hedman, Linnea
    et al.
    OLIN studies, Sunderby Hospital.
    Lindgren, Berit
    Perzanowski, Matthew
    Department of Environmental Health Sciences, Columbia University, New York.
    Rönmark, Eva
    Karolinska Institutet, Lung and Allergy Research.
    Agreement between parental and self-completed questionnaires about asthma in teenagers2005In: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 16, no 2, p. 176-181Article in journal (Refereed)
    Abstract [en]

    In studies of asthma in children, a common method is for the parents to complete questionnaires about their child's asthma symptoms. With longitudinal studies of asthma, children reach an age when they can complete the questionnaire themselves. The aim of this paper was to compare the prevalence of asthma symptoms as well as the agreement between responses to an asthma questionnaire completed by teenagers and their parents. As a part of the Obstructive Lung Disease in Northern Sweden Study (OLIN) pediatric study, where 3345, 13-14-yr-old children completed an asthma questionnaire, 294 (84%) randomly selected parents also completed the questionnaire, which included the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. There were no significant differences in the prevalence of wheeze in the last 12 months, ever asthma, or physician diagnosed asthma as reported by the parents compared with the teenagers. However, the teenagers reported a significantly higher prevalence of wheeze during or after exercise. The absolute agreement was generally very high while the level of agreement (kappa-value) was slightly lower. The highest results in both absolute agreement and kappa-value, were reached by the questions on diagnosis of asthma (98.9% and 0.93), use of asthma medicines (95.5% and 0.78), and whether the child ever had had asthma (97.2% and 0.86), respectively. In conclusion, the agreement between the parents' and the teenagers' responses to the asthma questionnaire was good. The change in methodology from parental to self-completion of the questionnaire did not affect the results in the study.

  • 119.
    Hedman, Linnea
    et al.
    Luleå University of Technology, Department of Health Sciences, Nursing Care. Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, The OLIN Unit, Umeå University, Umeå, Sweden.
    Stridsman, Caroline
    Luleå University of Technology, Department of Health Sciences, Nursing Care.
    Andersson, Martin
    Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, The OLIN Unit, Umeå University.
    Backman, Helena
    Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine, The OLIN Unit, Umeå University.
    Jansson, Sven-Arne
    Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, The OLIN Unit, Umeå University.
    Rönmark, Eva
    Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine/the OLIN unit, Umeå University.
    Population-based study shows that teenage girls with asthma had impaired health-related quality of life2017In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 106, no 7, p. 1128-1135Article in journal (Refereed)
    Abstract [en]

    Aim

    This study examined the health-related quality of life (HRQoL) of teenagers with and without asthma, including the impact of their sex, allergic conditions, smoking, living conditions and physical activity.

    Methods

    The Obstructive Lung Disease in Northern Sweden (OLIN) studies recruited a cohort of schoolchildren in 2006. The parents of all children aged seven to eight years in three municipalities were invited to complete a questionnaire and 2585 (96%) participated. The cohort was followed up at the ages of 11–12 years and 14–15 years with high participation rates. At 14–15 years, the HRQoL questionnaire KIDSCREEN-10 and Asthma Control Test were added.

    Results

    Girls with current asthma at 14–15 years had a lower mean HRQoL score than girls without asthma (46.4 versus 49.3, p < 0.001), but this was not seen among boys (53.8 versus 52.8, p = 0.373). Poor HRQoL was related to current asthma, uncontrolled asthma and teenage onset of asthma. It was also related to eczema, living in a single-parent household, maternal smoking, daily smoking and inversely related to physical activity.

    Conclusion

    Teenage girls with asthma had lower HRQoL than girls without asthma. Possible interventions to improve HRQoL among teenagers with asthma were identified as follows: increasing asthma control, preventing smoking and promoting physical activity.

  • 120.
    Hertting, Krister
    et al.
    Luleå University of Technology, Department of Arts, Communication and Education, Education, Language, and Teaching.
    Kostenius, Catrine
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    How can interactive technology be used to facilitate health and well-being in school?: Reflections from school children in the Barents region2014Conference paper (Refereed)
  • 121.
    Hertting, Krister
    et al.
    Luleå University of Technology, Department of Arts, Communication and Education, Education, Language, and Teaching.
    Kostenius, Catrine
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Organized leisure activities and well-being: children getting it just right!2012In: Larnet: Cyber Journal of Applied Leisure and Recreational Research, Vol. 15, no 2, p. 13-28Article in journal (Refereed)
    Abstract [en]

    This article explores how the levels of participation in organized leisure activities relate to children’s psychosocial well-being. Data collection occurred in a school district with 7 schools in the northern part of Sweden. Children ages 12-14 were invited to complete the World Health Organizations’ Health Behavior in School-Aged Children self-completion questionnaire (n=391). An independent variable was constructed to measure children’s participation in organized leisure activities at three levels: low level (LL), medium level (ML), and high level (HL). Ten out of 13 correlations were significant at the p< .05 level). Results indicated that the ML group scored high on life satisfaction, had a lot of friends, and felt less pressure in school than the other two groups, while the LL and HL groups had fewer friends and felt more pressure. The conclusion drawn is that a medium level of participation in organized leisure activities was most favorable for children’s health and well-being. Discussions include possibilities for finding the right balance between organized leisure activities and children’s well-being

  • 122.
    Hertting, Krister
    et al.
    Center of Research on Welfare, Health and Sport, Halmstad University.
    Kostenius, Catrine
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    The Youth Soccer Coaches’ Visions and Thoughts of Leader Support2016In: Physical Culture and Sport. Studies and Research, ISSN 2081-2221, E-ISSN 1899-4849, Vol. 70, no 1, p. 69-78Article in journal (Refereed)
    Abstract [en]

    The Objectives: The European Commission has highlighted the use of sports as an important venue for engaging citizens in health-enhancing activities, physical activity, volunteerism and active citizenship. Coaching is a central component of sports for children and youth, but there is little research on the promotion of sports coaches' health. In the light of this gap, the aim of this paper was to elucidate youth soccer coaches' visions and thoughts regarding leadership support from clubs and soccer associations. Design and method: The study was based on an online questionnaire conducted with Swedish soccer coaches who coached children and young people between 6 and 18 years of age. In total, 1514 coaches received the online questionnaire via email and 764 coaches (50.5% of the sample) answered. Three hundred and seventy-five coaches answered the open question: 'How would you describe the support you, as a coach, would like to receive from clubs and associations?' Responses were analysed using method. Results: Four main themes emerged from the analysis: financial and other resources support, recognition of contribution, sense of belonging to a value-based association and positive coach development. Conclusion: We discuss the factors that support soccer coaches and how these can serve as health-promoting supports for coaches working with children and youth.

  • 123.
    Holmbäck, Ulf C.
    et al.
    Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University.
    Forslund, Anders H.
    Department of Medical Sciences, Nutrition, Uppsala University Hospital.
    Forslund, Jeanette M.
    Department of Medical Sciences, Nutrition, Uppsala University Hospital.
    Hambræus, Leif M.
    Department of Biosciences, Unit for Preventive Nutrition, Karolinska Institute.
    Wiklund, Maria Lennernäs
    Institutet för psykosocial medicin (IPM), Avdelningen för stressforskning, Karolinska institutet.
    Löwden, Arne
    Stockholm University, Stress Research Institute.
    Stridsberg, Mats
    Department of Medical Science and Clinical Chemistry, Uppsala University Hospital.
    Åkerfeldt, Torbjörn
    Department of Medical Sciences, Nutrition, Uppsala University Hospital.
    Åkerstedt, Torbjörn
    National Institute for Psychosocial Factors and Health, Karolinska Institutet, Avdelningen för stressforskning, Karolinska institutet.
    Changes in blood lipid profile and endocrine response as a result of an isocaloric high carbohydrate or high-fat diet in consideration of circadian rhythm2001In: The FASEB Journal, ISSN 0892-6638, E-ISSN 1530-6860, Vol. 15, no 4, p. A640-Article in journal (Refereed)
  • 124.
    Holmbäck, Ulf C.
    et al.
    Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University.
    Forslund, Anders H.
    Department of Medical Sciences, Nutrition, Uppsala University Hospital, Clinical Chemistry Laboratory, Department of Medical Sciences, Uppsala University Hospital.
    Forslund, Jeanette M.
    Department of Medical Sciences, Nutrition, Uppsala University Hospital, Swedish Dairy Association, Karolinska Institute.
    Hambræus, Leif M.
    Department of Biosciences, Unit for Preventive Nutrition, Karolinska Institute, IPM - National Institute of Psychosocial Medicine, Karolinska Institutet.
    Wiklund, Maria Lennernäs
    Department of Medical Sciences, Nutrition, Uppsala University Hospital.
    Löwden, Arne
    Stockholm University, Stress Research Institute, Swedish Dairy Association, Karolinska Institute.
    Stridsberg, Mats
    Department of Medical Science and Clinical Chemistry, Uppsala University Hospital, IPM - National Institute of Psychosocial Medicine, Karolinska Institutet.
    Åkerstedt, Torbjörn
    National Institute for Psychosocial Factors and Health, Karolinska Institutet, Avdelningen för stressforskning, Karolinska institutet, IPM - National Institute of Psychosocial Medicine, Karolinska Institutet.
    Metabolic responses to nocturnal eating in men are affected by sources of dietary energy2002In: Journal of Nutrition, ISSN 0022-3166, E-ISSN 1541-6100, Vol. 132, no 7, p. 1892-1899Article in journal (Refereed)
    Abstract [en]

    Because night work is becoming more prevalent, we studied whether feeding at different times of a 24-h period would elicit different metabolic responses and whether dietary macronutrient composition would affect these responses. Seven men (26-43 y, 19.9-26.6 kg/m2) consumed two isocaloric diets, in a crossover design. The diets were a high carbohydrate (HC) diet [65 energy % (E%) carbohydrates, 20E% fat] and a high fat (HF) diet (40E% carbohydrates, 45E% fat). After a 6-d diet-adjustment period, the men were kept awake for 24 h and the food (continuation of respective diet) was provided as six isocaloric meals (i.e., every 4 h). Energy and substrate turnover, heart rate, mean arterial pressure (MAP), blood glucose, triacylglycerol (TAG), nonesterified fatty acid (NEFA) and glycerol were measured throughout the 24-h period. Significantly higher energy expenditure and NEFA concentration, and lower blood glucose and TAG concentrations were observed when the men consumed the HF diet than when they consumed the HC diet. Significant circadian patterns were seen in body and skin temperature (nadir, 0400-0500 h). When the men consumed the HF diet, significant circadian patterns were seen in fat oxidation (nadir, 0800-1200 h; plateau, 1200-0800 h), heat release (nadir, 0800-1200 h; plateau, 1600-0800 h), heart rate (nadir, 0000 h), blood glucose (nadir, 0800-1200 h; peak, 0000-0400 h), NEFA (nadir, 0800-1200 h; peak, 1200-2000 h) and TAG (nadir, 0800-1200 h; peak, 0400-0800 h) concentrations. Energy expenditure, carbohydrate oxidation, MAP and glycerol concentration did not display circadian patterns. Unequal variances eradicated most circadian effects in the HC-diet data. The increased TAG concentration in response to feeding at 0400 h might be involved in the higher TAG concentrations seen in shift workers. Distinct macronutrient/circadian-dependent postprandial responses were seen in most studied variables.

  • 125.
    Holmbäck, Ulf C.
    et al.
    Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University.
    Forslund, Anders H.
    Department of Medical Sciences, Nutrition, Uppsala University Hospital.
    Forslund, Jeanette M.
    Department of Medical Sciences, Nutrition, Uppsala University Hospital.
    Hambræus, Leif M.
    Department of Biosciences, Unit for Preventive Nutrition, Karolinska Institute.
    Wiklund, Maria Lennernäs
    Institutet för psykosocial medicin (IPM), Avdelningen för stressforskning, Karolinska institutet.
    Åkerfeldt, Torbjörn
    Department of Medical Sciences, Nutrition, Uppsala University Hospital.
    Löwden, Arne
    Stockholm University, Stress Research Institute.
    Åkerstedt, Torbjörn
    National Institute for Psychosocial Factors and Health, Karolinska Institutet, Avdelningen för stressforskning, Karolinska institutet.
    Changes in energy expenditure and substrate utilization as a result of a nigh carbohydrate or high fat diet in consideration of diurnal rhythm2000In: The FASEB Journal, ISSN 0892-6638, E-ISSN 1530-6860, Vol. 14, no 4, p. A790-Article in journal (Refereed)
  • 126.
    Holmbäck, Ulf C.
    et al.
    Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Department of Medical Sciences, Nutrition, Uppsala University Hospital.
    Forslund, Anders H.
    Department of Medical Sciences, Nutrition, Uppsala University Hospital.
    Löwden, Arne
    Stockholm University, Stress Research Institute, Institutet för psykosocial medicin (IPM), Avdelningen för stressforskning, Karolinska institutet.
    Forslund, Jeanette M.
    Department of Medical Sciences, Nutrition, Uppsala University Hospital.
    Åkerstedt, Torbjörn
    National Institute for Psychosocial Factors and Health, Karolinska Institutet, Avdelningen för stressforskning, Karolinska institutet, Department of Biosciences, Unit for Preventive Nutrition, Karolinska Institute.
    Wiklund, Maria Lennernäs
    Department of Medical Sciences, Nutrition, Uppsala University Hospital.
    Hambræus, Leif M.
    Department of Biosciences, Unit for Preventive Nutrition, Karolinska Institute.
    Stridsberg, Mats
    Department of Medical Science and Clinical Chemistry, Uppsala University Hospital.
    Endocrine responses to nocturnal eating: Possible implications for night work2003In: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215, Vol. 42, no 2, p. 2748-2755Article in journal (Refereed)
    Abstract [en]

    Background: Night work is becoming more common and shift workers display several metabolic disturbances. Aim: To study the endocrine responses in relation to time of day during a 24-h period and how dietary macronutrient composition affects these responses. Design: Seven males (26-43 y and 19.9-26.6 kg · m-2) were studied in a crossover design. Isocaloric diets described as highcarbohydrates (HC; 65 energy percent (E%) carbohydrates and 20E% fat) or high-fat (HF; 40E% carbohydrates and 45E% fat) were given. After a 6-day diet adjustment period, the subjects were kept awake for 24 h in a metabolic unit and were served an isocaloric meal (continuation of respective diet) every 4-h. Blood samples were taken throughout the 24-h period. Results: Insulin and leptin responses to meal intake differed with respect to time of day (p ≤ 0.05). Time of day affected glucagon, thyroid stimulating hormone (TSH), free thyroxin (fT4), total triiodothyronine (tT3), cortisol, chromogranin A (CgA) and pancreatic polypeptide (PP) concentrations (p ≤ 0.05). Meal intake decreased cortisol concentration after meals at 0800, 1200 and 0400 but not at 1600, 2000 and 0000 h. The PP's postprandial increase was greater during 0800-1600 h compared to 2000-0800 h. With the HC meals, lower glucagon and CgA concentrations (p ≤ 0.05), and a tendency for lower tT3 concentrations (p = 0.053) were observed compared to the HF meals. Conclusion: Insulin, PP, TSH, fT4, cortisol and leptin responses to meal intake differed with respect to time of day. The decreased evening/nocturnal responses of cortisol and PP to meal intake indicate that nocturnal eating and night work might have health implications.

  • 127.
    Holmbäck, Ulf C.
    et al.
    Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Department of Medical Sciences, Nutrition, Uppsala University Hospital.
    Löwden, Arne
    Stockholm University, Stress Research Institute, Institutet för psykosocial medicin (IPM), Avdelningen för stressforskning, Karolinska institutet.
    Åkerfeldt, Torbjörn
    Department of Medical Sciences, Nutrition, Uppsala University Hospital.
    Hambræus, Leif M.
    Department of Biosciences, Unit for Preventive Nutrition, Karolinska Institute.
    Wiklund, Maria Lennernäs
    Department of Medical Sciences, Nutrition, Uppsala University Hospital.
    Forslund, Jeanette M.
    Department of Medical Sciences, Nutrition, Uppsala University Hospital.
    Åkerstedt, Torbjörn
    National Institute for Psychosocial Factors and Health, Karolinska Institutet, Avdelningen för stressforskning, Karolinska institutet, Department of Biosciences, Unit for Preventive Nutrition, Karolinska Institute.
    Stridsberg, Mats
    Department of Medical Science and Clinical Chemistry, Uppsala University Hospital.
    Forslund, Anders H.
    Department of Medical Sciences, Nutrition, Uppsala University Hospital.
    The human body may buffer small differences in meal size and timing during a 24-h wake period provided energy balance is maintained2003In: Journal of Nutrition, ISSN 0022-3166, E-ISSN 1541-6100, Vol. 133, no 9, p. 2748-2755Article in journal (Refereed)
    Abstract [en]

    Because ∼20% of the work force in the industrialized world have irregular working hours, it is pertinent to study the consequences of eating at irregular, especially nighttime hours. We studied the postprandial responses during nocturnal fasting vs. e+ating throughout a 24-h wake period. Seven healthy males were studied twice in a crossover design. After a 6-d diet adjustment period [high fat diet, 45 energy percent (en%) fat, 40 en% carbohydrates)] with sleep from 2300 to 0700 h, the men were kept awake for 24 h at the metabolic ward and given either 6 isoenergetic meals, i.e., every 4 h (N-eat) or 4 isoenergetic meals from 0800 to 2000 h followed by a nocturnal fast (N-fast), with the same 24-h energy intake. Energy expenditure, substrate utilization, activity, heat release, body temperature and blood variables were measured over 24 h. Energy expenditure and blood glucose, triacylglycerol, insulin and glucagon concentrations were lower and nonesterified fatty acids concentrations were higher during the nocturnal fast than during nocturnal eating (P < 0.05); however, no 24-h differences between the protocols were apparent. Nocturnal fasting slightly altered the secretory patterns of the thyroid hormones and cortisol (P < 0.05). We found no clear indication that it would be more favorable to ingest few larger daytime meals than smaller meals throughout the 24-h period. The body seems to be able to buffer small differences in meal size and timing provided energy balance is maintained

  • 128.
    Hyun, Sang-Min
    et al.
    College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, Republic of Korea. Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, Republic of Korea.
    Joon Lee, Benjamin
    College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, Republic of Korea.
    Abuzar, Sharif Md
    College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, Republic of Korea. Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, Republic of Korea.
    Lee, Soohun
    College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, Republic of Korea. Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, Republic of Korea.
    Joo, Yechan
    College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, Republic of Korea. Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, Republic of Korea.
    Hong, Seung-Hyeon
    College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, Republic of Korea. Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, Republic of Korea.
    Kang, Han
    College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, Republic of Korea.
    Kwon, Kyung-Ae
    Dae Hwa pharmaceutical Co., Ltd., 2145 Nambusunhwan-ro, Seocho-gu, Seoul, Republic of Korea.
    Velaga, Sitaram
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Hwang, Sung-Joo
    College of Pharmacy, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, Republic of Korea. Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, Republic of Korea.
    Preparation, characterization, and evaluation of celecoxib eutectic mixtures with adipic acid/saccharin for improvement of wettability and dissolution rate2019In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 554, p. 61-71Article in journal (Refereed)
    Abstract [en]

    Celecoxib (CEL) is a selective cyclooxygenase-2 (COX-2) inhibitor therapeutically indicated for the treatment of rheumatoid arthritis, osteoarthritis, acute pain, and inflammation. However, its poor solubility and dissolution rate significantly hinders its broader application. In this study, eutectic mixtures, as binary pharmaceutical compositions of CEL with adipic acid (ADI) and saccharin (SAC), were identified through a phase diagram and Tammann’s triangle intended to improve the wettability and dissolution rate of poorly water-soluble CEL. The contact angles at 0s in the liquid-solid interface were approximately θs (theta) 79.7° ± 0.50° and 86.65° ± 0.45° for CEL-ADI and CEL-SAC, respectively, which were much lower than the value obtained for CEL (92.05° ± 0.75° θ). Moreover, a comparison of the disk intrinsic dissolution rate and powder dissolution properties demonstrated that eutectic mixtures significantly increased the dissolution rate compared with CEL and physical mixtures. A general relationship was elucidated and indicated that the dissolution rate was increased as the contact angle decreased (correlation coefficient, r = 0.9966 ± 0.0031). Therefore, CEL-ADI and CEL-SAC eutectics may offer a novel formulation strategy to enhance the solubility and oral bioavailability of CEL.

  • 129. Högberg, Sofie
    et al.
    Lundström, Staffan
    Luleå University of Technology, Department of Engineering Sciences and Mathematics, Fluid and Experimental Mechanics.
    Velaga, Sitaram
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Ljung, Anna-Lena
    Fluid mechanics of particle deposition in human lungs2005In: Contributed paper abstracts / American Association of Pharmaceutical Scientists: annual meeting and exposition, 2005Conference paper (Other academic)
    Abstract [en]

    Aim: To develop an ideal Computational Fluid Dynamic (CFD) model, which provides knowledge of fundamental characteristics of particles and their eventual deposition patterns in the respiratory system, to design an effective formulation for a specific therapeutic application (local or systemic) Methods: The whole flow field was measured in a single measurement using Particle Image Velocimetry (PIV). The concept was to add small sized particles to the flow. These particles were then illuminated by a thin laser-layer in the region of interest and the motion of the formed speckle pattern was captured by a CCD-camera. Results: In a preliminary study, the flow in the uppermost three generations of airways, with a focus on branches of rectangular cross-sections, has been investigated. This geometry was easily built from blocks of PMMA. The model captured the main flow features. A qualitative agreement between experiments and simulations was obtained as shown in Figure 1, a snap-shot taken during inhalation. The experiments further enable a more detailed study of the quality and trust of the simulations. The result of this is then applied on a more realistic model of the uppermost airways and the particle deposition simulated (Figure 2). Fig 1 Fig 2 Figure 1: PIV-measurements showing the velocity field, the upper CFD-graph is obtained for a k-? turbulent flow and the lower graph shows the field for a laminar; Figure 2: Virtual model of the upper part of the air-ways. Please notice that the grid was refined for the initial simulations Conclusions: Preliminary studies were initiated with an ultimate aim of developing a complete lung model. Our efforts so far yielded a good understanding of experimental and numerical visualisation of the flow in the uppermost airways and we are currently engaged in quantifying the results.

  • 130.
    Isaksson, Gunilla
    et al.
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Lexell, Jan
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Skär, Lisa
    Josephsson, Staffan
    Institutionen Neurotec, Sektionen för arbetsterapi, Karolinska institutet.
    Projekt: Det sociala nätverkets betydelse för delaktighet i dagliga aktiviteter - Erfarenheter från kvinnor med ryggmärgsskada och deras män2010Other (Other (popular science, discussion, etc.))
    Abstract [sv]

    Projektets övergripande syfte  Syftet med detta projekt var att få en fördjupad kunskap om och förståelse för upplevelsen av den sociala miljöns betydelse för delaktighet i dagliga aktiviteter hos kvinnor med en ryggmärgsskada och deras män samt om upplevelsen förändrades över tid.   Kort beskrivning av projektet  Projektet fokuserar på betydelsen av det sociala nätverket och dess relation till aktivitet och hälsa inom rehabilitering och arbetsterapi. Utgångspunkten var att det behövs en ökad kunskap om hur personer med funktionshinder upplever betydelsen av socialt stöd från det sociala nätverket eftersom en framgångsrik rehabilitering förutsätter att en person med funktionshinder upplever socialt stöd från det sociala nätverket. Målgruppen för att belysa detta har i projektet varit kvinnor som drabbats av en ryggmärgsskada, då de ofta får omfattande funktionshinder med förändrade vanor vid aktivitetsutförande samt förändrade relationer i deras sociala nätverk. Vidare för att kunskap om kvinnor med ryggmärgsskada är begränsad. I projektet har även män som var sammanboende med kvinnor med en ryggmärgsskada ingått. Metodologiskt har projektet en kvalitativ inriktning där deltagarna intervjuats om deras upplevelser av det sociala nätverkets betydelse för delaktighet i vardagen från strax före skadan fram till idag. Resultaten visar att över tid utvecklades ett förändrat samspel mellan kvinnorna och deras sociala nätverk som influerade deras delaktighet i dagliga aktiviteter. Resultatet påvisade även betydelsen av berättelser för att fånga dynamiken och komplexiteten i den förändringsprocess som både kvinnorna och männen som var sammanboende med dem gick igenom. Vidare hur klient-centrerad praxis som inkluderar även anhöriga kan utveckla en djupare förståelse för dynamiken och samspelet mellan personen, aktiviteter och socialt samspel.  Detta forskningsprojekt kan därför tillföra arbetsterapeuter, men även annan personal inom rehabilitering, en ökad kunskap om den sociala miljöns betydelse för utförandet av aktiviteter i det dagliga livet. 

  • 131.
    Jacobson, Inger
    et al.
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Hur ser en damfotbollspelare ut?1999In: Svensk idrottsmedicinsk förenings vårmöte: Ystad 1999, Svensk idrottsmedicinsk förening , 1999Conference paper (Other academic)
  • 132.
    Jacobson, Inger
    et al.
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Injuries among female football players - With special emphasis on region differences2007In: Svensk idrottsmedicinsk förenings vårmöte: Uppsala 2007, 2007, p. 43-Conference paper (Other academic)
  • 133.
    Jacobson, Inger
    et al.
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Injuries among female football players: with special emphasis on regional differences2007In: Abstraktbok Sjukgymnastdagarna 10-12 oktober 2007, Stockholm: LSR , 2007, p. 11-12Conference paper (Other academic)
  • 134.
    Jacobson, Inger
    et al.
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Injuries among female football players: with special emphasis on regional differences2006In: Advances in Physiotherapy, ISSN 1403-8196, E-ISSN 1651-1948, Vol. 8, no 2, p. 66-74Article in journal (Refereed)
    Abstract [en]

    In this 1-year prospective study, the aim was to investigate if there are any differences concerning injuries and injury incidence during an entire football season between Swedish female football players from different geographical regions. A total of 130 out of 253 players (51%) sustained 229 injuries. The overall injury incidence was 9.6/1000 h of football. The incidence of injury during practice was 8.4/1000 h and during game was 13.3/1000 h. Players in the north had a higher incidence of injury during game than those in the south (19.5 vs. 7.2/1000 h, respectively, p<0.001). Fifty-nine per cent of all injuries were traumatic injuries. Both traumatic and overuse injuries occurred mainly during the early preseason and at the beginning of the competitive spring season. Of all injuries, 13% were classified as slight, 39% as minor, 37% as moderate and 11% as major injuries. Players in the north had a higher injury incidence concerning moderate injuries than players in the south (p<0.01). In the present study, evidence is presented that regional factors play a role in the injury incidence. Female football players in the north and south have different injury patterns. This could be a result of different conditions for football as a sport between the regions.

  • 135.
    Jacobson, Inger
    et al.
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Injuries among swedish female elite football players: a prospective population study2007In: Abstraktbok Sjukgymnastdagarna 10-12 oktober 2007, Stockholm: LSR , 2007, p. 12-Conference paper (Other academic)
  • 136.
    Jacobson, Inger
    et al.
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Injuries among Swedish female elite football players: a prospective population study2007In: Svensk idrottsmedcinsk förenings vårmöte: Uppsala 2007, 2007, p. 44-Conference paper (Other academic)
  • 137.
    Jacobson, Inger
    et al.
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Injuries among swedish female elite football players: a prospective population study2007In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 17, no 1, p. 84-91Article in journal (Refereed)
    Abstract [en]

    Injury occurrence in all 12 female elite senior football teams in premiere league was registered during 1 year. Of 269 players, 129 (48%) sustained 237 injuries. The total injury incidence was 4.6/1000 h of football. The injury incidence during practice was 2.7 and during the game time was 13.9/1000 h. The highest injury incidence during practice was to the knee (0.8/1000 h) and thigh (0.5/1000 h), and during game time was to the knee (4.4/1000 h) and head (2.2/1000 h). In total, the location for the highest injury incidence was the knee with 1.5 injuries/1000 h of football. The majority of injuries (82%) were localized to the lower extremities. Sixty-six injuries (28%) were re-occurring injuries (re-injuries). The incidence of traumatic injuries was 3.3/1000 h of football and for overuse injuries 1.3/1000 h. Overuse injuries occurred mainly during the preseason and at the beginning of the spring season. Thirty-nine percent of the injuries were slight or minor causing absence from practice or game time of less than 1 week, 39% were moderate (absence 7-28 days) and 22% were major (absence more than 28 days). The major injuries occurred often owing to trauma and were mainly to the knee.

  • 138.
    Jacobson, Inger
    et al.
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Range of motion in relation to upcoming sprain and strain injuries among female football players2007In: Abstraktbok Sjukgymnastdagarna 10-12 oktober 2007, Stockholm: LSR , 2007, p. 32-Conference paper (Other academic)
  • 139.
    Jacobson, Inger
    et al.
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Range of motion in relation to upcoming sprain and strain injuries among female football players2007In: Svensk idrottsmedicinsk förenings vårmöte: Uppsala 2007, 2007, p. 42-Conference paper (Other academic)
  • 140.
    Jacobson, Inger
    et al.
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Skador inom svensk damfotboll2000In: Svensk idrottsmedicinsk förenings vårmöte: Stockholm 2000, Svensk idrottsmedicinsk förening , 2000Conference paper (Other academic)
  • 141.
    Jacobsson, Lars
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Long-term outcome after traumatic brain injury: studies of individuals from northern Sweden2010Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    As traumatic brain injury (TBI) is as one of the major causes of long-term disability, there is an increasing interest in the long-term outcome of TBI. The overall aim of this thesis was to increase our knowledge and understanding of the situation for individuals many years post injury, with regard to demographics, injury characteristics and primary outcome, long-term functioning and disability, health-related quality of life, life satisfaction, self-appraisal of the impact of the TBI and sense of coherence.In study I, data was retrospectively collected on those individuals in Norrbotten, northern Sweden, with a computed tomography (CT) verified TBI and brain injury symptoms, who had been transferred for neurosurgical care between 1992 to 2001. A total of 332 individuals, 250 men and 82 women, were registered. The findings revealed that a majority were older men with a mild TBI following a fall. Younger individuals were fewer in number but more often had a severe TBI from a traffic accident. Most individuals received post-acute care and brain injury rehabilitation. A majority had a moderate or severe disability, but many were discharged back from hospital and sent home with no major changes in their physical or social environment. In study II, 88 individuals (age between 18 and 65 at the time of assessment, to represent individuals of working age) were included and their functioning and disability were assessed with internationally established TBI outcome measures, on average 10 years (range 6-15 years) post injury. There was an improvement in overall outcomes from the time of discharge from inpatient rehabilitation to follow-up, and many had a high degree of motor and cognitive functioning, which enabled them to live independently in their own home without assistance. There remained, however, a disability related to community reintegration and social participation. This affected their productivity and to some degree their marital stability, factors which were related to the age at the time of injury and the severity of the injury. In study III, health-related quality of life (HRQoL) and life satisfaction (LS) were assessed in 67 individuals, and compared with reference values from the general population. HRQoL, as well as LS, was lower compared with the general population. Multivariate statistical analyses showed that the individuals’ own appraisal of the impact of the TBI, along with vocational productivity, were most strongly associated with their current physical health and overall satisfaction with life. In study IV, sense of coherence (SOC) and the influence on self-rated LS of SOC, along with measures of functioning and disability, sex, age at injury, injury severity and time since injury were assessed in 66 individuals. SOC did not differ from the general population, and there was a strong relationship between SOC and LS indicating that the individuals’ sense of preservation of good health was strongly associated with high LS. High LS was also strongly associated with emotional factors and social participation, together with longer time post-injury and a more severe injury sustained at a later age.In conclusion, the results indicate that many individuals with a TBI can achieve and maintain a high degree of functioning many years after the injury. However, emotional and inter-relational problems remain and impact on social activities and participation. Many individuals experienced a reduced HRQoL and LS. The individuals’ perception of the low impact of the injury and their positive SOC were firmly associated with high LS. These results confirm that TBI can lead to long-term disability and emphasize the need for support systems and rehabilitation programmes that can meet the individuals’ needs, with regard to emotional factors, social participation and overall satisfaction with life, in a long-term perspective.

  • 142.
    Jacobsson, Lars
    et al.
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Lexell, Jan
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Life satisfaction after traumatic brain injury: comparison of ratings with the Life Satisfaction Questionnaire (LiSat-11) and the Satisfaction With Life Scale (SWLS)2016In: Health and Quality of Life Outcomes, ISSN 1477-7525, E-ISSN 1477-7525, Vol. 14, no 1, article id 10Article in journal (Refereed)
    Abstract [en]

    Background An optimal life satisfaction (LS) is considered an important long-term outcome after a traumatic brain injury (TBI). It is, however, not clear to what extent a single instrument captures all aspects of LS, and different instruments may be needed to comprehensively describe LS. The aim of this study was to compare self-ratings of life satisfaction after a TBI with two commonly used instruments. Methods Life Satisfaction Questionnaire (LiSat-11), comprising eleven items and Satisfaction With Life Scale (SWLS), comprising five items, were administered to 67 individuals (51 men and 16 women). Secondary analysis of data collected as part of a survey of individuals with TBI 6 to 15 years post TBI. Results Item 1 in LiSat-11 (‘Life as a whole’) and the total SWLS score was strongly correlated (Spearman’s rho = 0.66; p < 0.001). The total score in SWLS had the strongest correlation with items in LiSat-11. All items in LiSat-11, except ‘Family life’ and ‘Partner relationship’, were moderately to strongly correlated with items in SWLS. The item ‘Partner relationship’ in LiSat-11 did not correlate with any of the items in SWLS or the total score. The item ‘If I could live my life over, I would change nothing’ in SWLS had the weakest correlations with items in LiSat-11. Items ‘Vocation’ and ‘Leisure’ in LISat-11 were most strongly correlated with items in SWLS, whereas the item ‘ADL’ in LiSat-11 was more weakly correlated with items in SWLS. Conclusions The strength of the relationships implies that the two instruments assess similar but not identical aspects of LS and therefore complement each other when it is rated.

  • 143.
    Jacobsson, Lars
    et al.
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Lexell, Jan
    Department of Neurology and Rehabilitation Medicine, Skåne University Hospital, Lund-Malmö.
    Long-term outcome after traumatic brain injuries in Northern Sweden: Changes in life satisfaction and sense of coherence between 6-15 and 12-21 years post-injury2016In: Brain Injury, ISSN 0269-9052, E-ISSN 1362-301X, Vol. 30, no 5-6, p. 574-Article in journal (Other academic)
  • 144.
    Jacobsson, Lars
    et al.
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Westerberg, Mats
    Luleå University of Technology, Department of Business Administration, Technology and Social Sciences, Innovation and Design.
    Malec, J.
    Rehabilitation Hospital of Indiana and Indiana University School of Medicine.
    Lexell, Jan
    Luleå University of Technology, Department of Health Sciences.
    Sense of coherence and disability and the relationship with life satisfaction 6 to 15 years after traumatic brain injuries in northern Sweden2011In: Neuropsychological rehabilitation (Print), ISSN 0960-2011, E-ISSN 1464-0694, Vol. 23, no 1, p. 383-400Article in journal (Refereed)
    Abstract [en]

    The objective of the study was to assess sense of coherence (SOC) many years after traumatic brain injury (TBI) and explore the relationship between SOC and self-rated life satisfaction (LS) as well as measures of functioning and disability, sex, age at injury, injury severity and time post-injury. Sixty-six individuals (aged 18-65 years) who were 6-15 years post-injury were interviewed. Data on SOC (SOC-13 item scale), measures of functioning and disability (Mayo-Portland Adaptability Inventory, MPAI-4), LS (Satisfaction with Life Scale, SWLS), and sex, age at injury, injury severity and time post-injury were analysed with hierarchical multiple regression analyses. The results showed that SOC in the study group did not differ from the general population and was strongly associated with LS. Regression analyses revealed that emotional factors, social participation, SOC, and time since injury, were more influential than sex, age at injury, and injury severity in explaining LS. It was concluded that SOC in this group of individuals with TBI who were many years post-injury was similar to nondisabled individuals. SOC, together with emotional factors, social participation and injury-related factors, were determinants of LS. These results confirm that LS after TBI is a complex phenomenon dependent on several factors that are important targets for rehabilitation professionals.

  • 145.
    Jansson, Maria
    et al.
    Luleå University of Technology, Department of Health Sciences.
    Mörtberg, Christina
    Department of Informatics, University of Oslo, Norway. Unoversity of Umeå.
    Mirijamdotter, Anita
    School of Mathematics and Systems Engineering, Växjö University, Växjö, Sweden.
    Participation in e-Home Healthcare @ North Calotte2008In: Proceedings of the 5th Nordic Conference on Human-Computer Interaction: Building Bridgees / [ed] Gulz, A., Magnusson, C., Malmborg, L., Eftring, H., Jönsson, B., and Tollmar, K., Association for Computing Machinery (ACM), 2008, p. 192-200Conference paper (Refereed)
    Abstract [en]

    Participation and the contribution of participatory design methods and techniques are explored in the context of a Scandinavian Home Healthcare project. The project was undertaken during 2004-2005. Its aim was to introduce mobile ICT equipment to health care workers in order to improve planning, including quality and precision of information exchange. The study was designed according to Participatory Action Research and Participatory Design principles. Methods employed in the project were observations, interviews, future workshops, and story boards to actively involve different stakeholders. The experience of the project indicates that, although the rhetoric was that of a participatory design and research project, participants are not equally regarded in terms of experiences and knowledge of the actual practice. Assumptions about technology influence development and implementation at the expense of the actual care activity. Further, participation and participatory design techniques used in the project demonstrate the complexity of home healthcare and the necessity to involve all the different occupational groups involved in the care of the client. However, organisational boundaries reinforced shortcomings in cross-functional and cross organisational cooperation. A final conclusion is that time for collaborative and collegial reflections is a necessity to support the learning process.

  • 146.
    Jara, Miguel O.
    et al.
    Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile.
    Catalan-Figueroa, Johanna
    Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile.
    Landin, Mariana
    Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago, Santiago de Compostela, Spain.
    Morales, Javier O.
    Luleå University of Technology, Department of Health Sciences, Medical Science. Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical SciencesUniversity of Chile, Santiago, Chile. Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile.
    Finding key nanoprecipitation variables for achieving uniform polymeric nanoparticles using neurofuzzy logic technology2018In: Drug Delivery and Translational Research, ISSN 2190-393X, Vol. 8, no 6, p. 1797-1806Article in journal (Refereed)
    Abstract [en]

    Nanoprecipitation is a simple and fast method to produce polymeric nanoparticles (Np); however, most applications require filtration or another separation technique to isolate the nanosuspension from aggregates or polydisperse particle production. In order to avoid variability introduced by these additional steps, we report here a systematic study of the process to yield monomodal and uniform Np production with the nanoprecipitation method. To further identify key variables and their interactions, we used artificial neural networks (ANN) to investigate the multiple variables which influence the process. In this work, a polymethacrylate derivative was used for Np (NpERS) and a database with several formulations and conditions was developed for the ANN model. The resulting ANN model had a high predictability (> 70%) for NpERS characteristics measured (mean size, PDI, zeta potential, and number of particle populations). Moreover, the model identified production variables leading to polymer supersaturation, such as mixing time and turbulence, as key in achieving monomodal and uniform NpERS in one production step. Polymer concentration and type of solvent, modifiers of polymer diffusion and supersaturation, were also shown to control NpERS characteristics. The ANN study allowed the identification of key variables and their interactions and resulted in a predictive model to study the NpERS production by nanoprecipitation. In turn, we have achieved an optimized method to yield uniform NpERS which could pave way for polymeric nanoparticle production methods with potential in biological and drug delivery applications.

  • 147.
    Jonsson, B-A
    et al.
    Department of Medical Biosciences, Medical and Clinical Genetics, Umeå University Hospital.
    Stattin, E-L
    Department of Medical Biosciences, Medical and Clinical Genetics, Umeå University Hospital.
    Wiklund, F.
    Medical Epidemiology and Biostatistics, Karolinska Institute.
    Lindblom, K.
    Department of Experimental Medical Sciences, Lund University.
    Önnverfjord, P.
    Department of Experimental Medical Sciences, Lund University.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Sasaki, T.
    Department of Experimental Medicin I, University of Erlangen-Nuernberg.
    Struglics, A.
    Department of Clinical Sciences, Lund University.
    Lohmander, S.
    Department of Clinical Sciences, Lund University.
    Dahl, N.
    Department of Genetics and Pathology, The Rudbeck Laboratory, Uppsala University.
    Heinegård, D.
    Department of Experimental Medical Sciences, Lund University.
    Aspberg, A.
    Department of Biology, University of Copenhagen.
    A missense mutation in the aggrecan C-type lectin domain disrupts extracellular matrix interactions and causes dominant familial osteochondritis dissecans with short stature and early osteoarthritis2009Conference paper (Other academic)
  • 148.
    Jonsson, Johan
    et al.
    Västmanland hospital, Västmanlands sjukhus Västerås.
    Jonsson, Mattias
    Västmanland hospital, Västmanlands sjukhus Västerås.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    The Epidemiology of Overuse Injuries in Ice Hockey: An Analysis from 29 Seasons in the Swedish Elite League2019In: Orthopedics and sports medicine, ISSN 2638-6003, Vol. 2, no 4Article in journal (Refereed)
    Abstract [en]

    Background: An overuse injury is considered to be the result of iterated micro trauma or monotonous movements. Sports related to monotonous and repetitive movements have a high amount of overuse injuries. Ice hockey with its complexity of movements makes the player exposed to overuse injuries. The aim of this study was to analyze overuse injuries, and to study the long-term injury panorama. It is the first and essential step to obtain an injury-prevention method.Study Design: Descriptive epidemiological study.Method: Data from an elite ice hockey team was prospectively collected from 29 seasons. The definition of an overuse injury was a gradual onset injury caused by repeated micro trauma without a single identifiable event responsible for that injury and which resulted in absence from ice hockey. Result: 315 overuse injuries were registered and accounted for 16.2% of all injury registrations. An overuse injury led on average to 1.8 missed games, 6.5 missed training sessions and 8.4 days of absence. August and September were the most injury months for an injury, with a total of 38.7% of the events. The most affected body region was the hip and groin, as 67.3% of all overuse injuries arose there. The second and third most affected body regions were the back and the knee respectively.Conclusion: The present study reports that overuse injuries are a relevant problem. Primarily hip and groin are frequently affected. The beginning of the on-ice season has shown to be the most vulnerable period

  • 149.
    Jullian, Carolina
    et al.
    Departamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile.
    Morales, Javier O.
    Departamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile.
    Zapata-Torres, Gerald
    Departamento de Química Inorgánica y Analítica, Facultad de de Ciencias Químicas y Farmacéuticas, Universidad de Chile.
    Aguilera, Benjamín
    Departamento de Química Inorgánica y Analítica, Facultad de de Ciencias Químicas y Farmacéuticas, Universidad de Chile.
    Rodriguez, Jorge
    Departamento de Química Inorgánica y Analítica, Facultad de de Ciencias Químicas y Farmacéuticas, Universidad de Chile.
    Arán, Vicente
    Instituto de Química Médica, CSIC.
    Olea-Azar, Claudio
    Departamento de Química Inorgánica y Analítica, Facultad de de Ciencias Químicas y Farmacéuticas, Universidad de Chile.
    Characterization, phase-solubility, and molecular modeling of inclusion complex of 5-nitroindazole derivative with cyclodextrins.2008In: Bioorganic & Medicinal Chemistry, ISSN 0968-0896, E-ISSN 1464-3391, Vol. 16, no 9, p. 5078-5084Article in journal (Refereed)
    Abstract [en]

    The slightly water-soluble 5-nitroindazole derivative (5-NI) and its inclusion with either beta-cyclodextrin (betaCD) or Heptakis (2,6-di-O-methyl)-beta-cyclodextrin (DMbetaCD) were investigated. The stoichiometric ratios and stability constants describing the extent of formation of the complexes were determined by phase-solubility measurements obtaining type-A(L) diagrams in both cases. According to the continuous variation method (Job's plot) a 1:1 stoichiometry has been proposed for the complexes. Also electrochemical studies were carried out on both CDs complexes, where the observed change in the E(PC) value for DMbetaCD indicated a lower feasibility of the nitro group reduction. The detailed spatial configuration is proposed based on two-dimensional NMR methods. These results are further interpreted using molecular modeling studies. The latter results are in good agreement with the experimental data.

  • 150.
    Jung, Min-Sook
    et al.
    Chungnam National University.
    Kim, Jeong-Soo
    Chungnam National University.
    Kim, Min-Soo
    Chungnam National University.
    Alhalaweh, Amjad
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Cho, Wonkyung
    Chungnam National University.
    Hwang, Sung-Joo
    Chungnam National University.
    Velaga, Sitaram
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Bioavailability of indomethacin-saccharin cocrystals2010In: Journal of Pharmacy and Pharmacology (JPP), ISSN 0022-3573, E-ISSN 2042-7158, Vol. 62, no 11, p. 1560-1568Article in journal (Refereed)
    Abstract [en]

    Pharmaceutical cocrystals are new solid forms with physicochemical properties that appear promising for drug product development. However, the in-vivo bioavailability of cocrystals has rarely been addressed. The cocrystal of indomethacin (IND), a Biopharmaceutical Classification System class II drug, with saccharin (SAC) has been shown to have higher solubility than IND at all pH. In this study, we aimed to evaluate the in-vitro dissolution and in-vivo bioavailability of IND-SAC cocrystals in comparison with IND in a physical mixture and the marketed product Indomee (R).MethodsScale-up of the cocrystals was undertaken using cooling batch crystallisation without seeding. The chemical and physical purity of the up-scaled material was verified using high-performance liquid chromatography, differential scanning calorimetry and powder X-ray diffraction. The IND-SAC cocrystals and IND plus SAC were mixed with lactose and the formulations were placed into gelatin capsules. In-vitro dissolution studies were then performed using the rotating basket dissolution method. The intrinsic dissolution rate of IND and IND-SAC cocrystals was also determined. Finally, a bioavailability study for the formulations was conducted in beagle dogs. The plasma samples were analysed using high-performance liquid chromatography and the pharmacokinetic data were analysed using standard methodologies.Key findingsThe bulk cocrystals (i.e. scaled-up material) were chemically and physically pure. The in-vitro dissolution rate of the cocrystals was higher than that of IND and similar to that of Indomee (R) at pH 7.4 and pH 1.2. The in-vivo bioavailability of the IND-SAC cocrystals in dogs was significantly higher (ANOVA, P < 0.05) than that of IND but not significantly different from Indomee (R) (ANOVA, P > 0.05).ConclusionsThe study indicates that the improved aqueous solubility of the cocrystals leads to improved bioavailability of IND. Thus, the cocrystals are a viable alternative solid form that can improve the dissolution rate and bioavailability of poorly soluble drugs.

1234567 101 - 150 of 546
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf