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  • 351.
    Velaga, Sitaram
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Basavoju, Srinivas
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Boström, Dan
    Energy Technology and Thermal Process Chemistry, Umeå University.
    Norfloxacin saccharinate-saccharin dihydrate cocrystal: a new pharmaceutical cocrystal with an organic counter ion2008Inngår i: Journal of Molecular Structure, ISSN 0022-2860, E-ISSN 1872-8014, Vol. 859, nr 1-3, s. 150-153Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A novel pharmaceutical cocrystal was obtained with an organic counter ion. Norfloxacin saccharinate dihydrate and its cocrystal, norfloxacin saccharinate-saccharin dihydrate, were crystallized.

  • 352.
    Velaga, Sitaram
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Djuris, Jelena
    Department of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy.
    Cvijic, Sandra
    Department of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy.
    Rozou, Stavroula
    Elpen Pharmaceutical Co..
    Russo, Paola
    Department of Pharmacy, University of Salerno.
    Colombo, Gaia
    Department of Life Sciences and Biotechnology, University of Ferrara.
    Rossi, Alessandra
    Food and Drug Department, University of Parma.
    Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products2018Inngår i: European Journal of Pharmaceutical Sciences, ISSN 0928-0987, E-ISSN 1879-0720, Vol. 113, s. 18-28Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In vitro dissolution testing is routinely used in the development of pharmaceutical products. Whilst the dissolution testing methods are well established and standardized for oral dosage forms, i.e. tablets and capsules, there are no pharmacopoeia methods or regulatory requirements for testing the dissolution of orally inhaled powders. Despite this, a wide variety of dissolution testing methods for orally inhaled powders has been developed and their bio-relevance has been evaluated.

    The review provides an overview of the in vitro dissolution methodologies for dry inhalation products, with particular emphasis on dry powder inhaler, where the dissolution behavior of the respirable particles can have a role on duration and absorption of the drug. Dissolution mechanisms of respirable particles as well as kinetic models have been presented. A more recent bio-relevant dissolution set-ups and media for studying inhalation biopharmaceutics were also reviewed. In addition, factors affecting interplay between dissolution and absorption of deposited particles in the context of biopharmaceutical considerations of inhalation products were examined.

  • 353.
    Velaga, Sitaram
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Nikjoo, Dariush
    Luleå tekniska universitet, Institutionen för teknikvetenskap och matematik, Materialvetenskap.
    Rao Vuddanda, Parameswara
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Drying Kinetics of Polymeric Films: theoretical and experimental studies2016Konferansepaper (Fagfellevurdert)
  • 354.
    Velaga, Sitaram
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Nikjoo, Dariush
    Luleå tekniska universitet, Institutionen för teknikvetenskap och matematik, Materialvetenskap.
    Rao Vuddanda, Parameswara
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap. Department of Pharmaceutics, UCL School of Pharmacy, University College London.
    Experimental Studies and Modeling of the Drying Kinetics of Multicomponent Polymer Films2018Inngår i: AAPS PharmSciTech, ISSN 1530-9932, E-ISSN 1530-9932, Vol. 19, nr 1, s. 425-435Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The process of drying thin polymer films is an important operation that influences the film structure and solid state, and the stability of the product. The purpose of this work was to study and model the drying kinetics of multicomponent films based on two polymers: hydroxypropyl methylcellulose (HPMC, amorphous) and polyvinyl alcohol (PVA, semicrystalline). The isothermal drying kinetics of the films at different temperatures (40, 60, and 80°C) were studied using thermo-gravimetric analysis (TGA) and convection oven methods. Solid-state characterization tools used in the study included polarization and hot-stage microscopy, scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). The drying kinetics of HPMC and PVA films in the TGA apparatus and convection oven were comparable. The three-parameter (Wmax, τ, n) Hill equation successfully modeled the experimental drying kinetics. The time factor τ in the Hill equation nicely explained two drying phases in the films. Solid-state phase changes occurring in the films during dehydration had a bearing on the drying kinetics and mechanisms. TGA can be used as a simple tool to determine the end points in drying processes using ovens or tunnels. The three-parameter Hill equation explained the drying kinetics and diffusion mechanisms of the solvent through the polymer films for the first time. This study advances our understanding of film drying, in particular for pharmaceutically relevant thin films.

  • 355.
    Velaga, Sitaram
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Taylor, David M.
    Maudsley Hospital, Pharmacy Department .
    Werneke, Ursula
    Division of Psychiatry, Sunderby Research Unit, Department of Clinical Sciences, Umeå University.
    Reducing the stigma of long acting injectable antipsychotics: current concepts and future developments2018Inngår i: Conference proceedings of the 4th Masterclass Psychiatry: Transcultural Psychiatry – Diagnostics and Treatment, Luleå, Sweden, 22–23 February 2018 (Region Norrbotten in collaboration with the Maudsley Hospital and Tavistock Clinic London) / [ed] Ursula Werneke, Taylor & Francis, 2018, s. 30-33Konferansepaper (Fagfellevurdert)
    Abstract [en]

    Background: Long acting injectable antipsychotics (LAIAPs) are considered a major advance in psychiatric treatment concerning treatment adherence and outcomes. Yet, both, doctors and patients, remain sceptical.

    Aim: To explain the rationale for using LAI-APs, review their effectiveness and explore barriers to use. Method: Clinical overview of LAI-APs from the patient and doctor perspective.

    Results: LAI-APs were developed to increase adherence to treatment, thereby improving treatment outcomes. LAI-APs may reduce risk of relapse and hospitalization. Yet, the evidence from the few meta-analyses available remains weak. Both patients and doctors may associate LAI-APs with stigma and coercion. Current means of improving adherence include more focus on the therapeutic relationship, better information, adverse effects minimization and halflife extension of LAI-APs. Future means of improving adherence include novel administration techniques that abolish the need for injection.

    Conclusions: For both, clinicians and drug developers, drug adherence remains a major target for improving treatment outcomes.

  • 356.
    Velaga, Sitaram
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Vangala, Venu R.
    Basavoju, Srinivas
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Boström, Dan
    Umeå university.
    Polymorphism in acesulfame sweetener: structure-property and stability relationships of bending and brittle crystals2010Inngår i: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 46, nr 21, s. 3562-3564Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Acesulfame is found to exist in two crystalline forms of which Form I (needles) shows bending upon mechanical stress. Crystal structures explain their mechanical response. This is the first case of aliphatic organic compounds featuring a bending phenomenon. Form I is physically more stable than Form II in ambient conditions.

  • 357.
    Vijayakumar, Mahalingam Rajamanickam
    et al.
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Kosuru, Ramoji
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Vuddanda, Parameswara Rao
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Singh, Sanjay Kumar
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Singh, Sanjay
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Trans resveratrol loaded DSPE PEG 2000 coated liposomes: An evidence for prolonged systemic circulation and passive brain targeting2016Inngår i: Journal of Drug Delivery Science and Technology, ISSN 1773-2247, Vol. 33, s. 125-135Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Trans resveratrol (RSV) is a natural molecule proved for cardioprotective effects, vasodilation, anti-inflammatory, cancer preventive and therapeutic activities devoid of any potential side effects. Recently, anti cancer potential against glioma cells were also reported with proven molecular mechanisms. However, the therapeutic application of RSV in clinical disease management is restricted because of its rapid elimination from systemic circulation and thereby low biological half life in mammals. Therefore, the main objective of this study was to improve the systemic circulation and biological half life of RSV using DSPE PEG 2000 decorated (PEGylated) liposomes. Moreover, brain distribution of RSV loaded PEGylated liposomes (RSV-PEG-Lipo) and non-PEGylated liposomes (RSV-Lipo) was also evaluated for proving their passive brain targeting ability. In vitro drug release of both liposomes was found to be sustained up to 48 h. RSV-PEG-Lipo showed higher area under the curve, plasma half life and mean residence time and lower volume of distribution and clearance than that of pristine RSV solution and RSV-Lipo. Pharmaokinetics results clearly indicated that the RSV-PEG-Lipo will be promising tool for enhancing plasma half life and prolong the systemic circulation of RSV. Brain distribution studies revealed that the liposomal formulations can be applied as an effective tool for passive brain targeting useful in the treatment of glioma.

  • 358.
    Vijayakumar, Mahalingam Rajamanickam
    et al.
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Kumari, Lakshmi
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Patel, Krishna Kumar
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Vuddanda, Parameswara Rao
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Vajanthri, Kiran Yellappa
    School of Biomedical Engineering, Indian Institute of Technology (Banaras Hindu University).
    Mahto, Sanjeev Kumar
    School of Biomedical Engineering, Indian Institute of Technology (Banaras Hindu University).
    Singh, Sanjay
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Intravenous administration of trans-resveratrol-loaded TPGS-coated solid lipid nanoparticles for prolonged systemic circulation, passive brain targeting and improved in vitro cytotoxicity against C6 glioma cell lines2016Inngår i: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 6, nr 55, s. 50336-50348Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    trans-Resveratrol (RSV), a natural molecule isolated from red wine, is widely known for several therapeutic potentials. RSV is proved for cardioprotective, vasodilation, anti-inflammatory, and anticancer effects. Recently, anticancer potential against glioma cells has also been reported. However, the clinical application of RSV in glioma treatment is largely limited because of its rapid metabolism and elimination from systemic circulation thereby exhibiting low biological half-life and poor brain distribution as well. Therefore, the main objective of this study was to enhance the circulation time, biological half-life and passive brain targeting of RSV using D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-coated solid lipid nanoparticles (RSV-TPGS-SLN). RSV-TPGS-SLN formulations were prepared by a solvent emulsification evaporation method and evaluated for several nanoparticulate characteristics. In vitro anticancer potential and cellular internalization of nanoparticles were also investigated in C6 glioma cell lines. Pharmacokinetics and biodistribution studies were carried out following intravenous administration in healthy Charles Foster rats. RSV-TPGS-SLN showed significantly higher in vitro cytotoxicity against C6 glioma cell lines and excellent cellular internalization. RSV-TPGS-SLN showed 11.12 and 9.37 times higher area under the curve and plasma half-life than RSV solution, respectively. Moreover, brain distribution of RSV-TPGS-SLN was found to be 9.23 times higher in comparison to that of RSV alone. Thus, we anticipate that the RSV-TPGS-SLN formulation can be applied as a potential tool for improving circulation time, biological half-life and passive brain targeting of RSV, thereby being immensely useful in the treatment of glioma.

  • 359.
    Vuddanda, Parameswara Rao
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap. Department of Pharmaceutics, UCL School of Pharmacy, University College London, London, United Kingdom.
    Alomari, Mustafa
    Department of Pharmaceutics, UCL School of Pharmacy, University College London.
    Dodoo, Cornelius C.
    Department of Pharmaceutics, UCL School of Pharmacy, University College London.
    Trenfield, Sarah J.
    Department of Pharmaceutics, UCL School of Pharmacy, University College London.
    Velaga, Sitaram
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Basit, Abdul W.
    Department of Pharmaceutics, UCL School of Pharmacy, University College London.
    Gaisford, Simon
    Department of Pharmaceutics, UCL School of Pharmacy, University College London.
    Personalisation of warfarin therapy using thermal ink-jet printing2018Inngår i: European Journal of Pharmaceutical Sciences, ISSN 0928-0987, E-ISSN 1879-0720, Vol. 117, s. 80-87Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Warfarin is a widely used anticoagulant that is critical in reducing patient morbidity and mortality associated with thromboembolic disorders. However, its narrow therapeutic index and large inter-individual variability can lead to complex dosage regimes. Formulating warfarin as an orodispersible film (ODF) using thermal ink-jet (TIJ) printing could enable personalisation of therapy to simplify administration. Commercial TIJ printers are currently unsuitable for printing the milligram dosages, typically required for warfarin therapy. As such, this study aimed to modify a commercial TIJ printing system to formulate personalised warfarin ODFs containing therapeutic dosages. A TIJ printer was modified successfully with the printer functionality intact; the substrate (paper) rolling mechanism of the printer was replaced by printing onto a stationary stage. Free film substrates were composed of hydroxypropyl methylcellulose (20%w/w) and glycerol (3%w/w). The resulting ODFs were characterised for morphology, disintegration, solid-state properties and drug content. Printed film stability was assessed at 40 °C/75% relative humidity for 30 days. Therapeutic warfarin doses (1.25 and 2.5 mg) were successfully printed onto the film substrates. Excellent linearity was observed between the theoretical and measured dose by changing the warfarin feed concentration (R2 = 0.9999) and length of the print objective, i.e. the Y-value, (R2 = 0.9998). Rapid disintegration of the ODFs was achieved. As such, this study successfully formulated personalised warfarin ODFs using a modified TIJ printer, widening the range of applications for TIJ printing to formulate narrow therapeutic index drugs.

  • 360.
    Vuddanda, Parameswara Rao
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Mathew, Aji P.
    Luleå tekniska universitet, Institutionen för teknikvetenskap och matematik, Materialvetenskap.
    Velaga, Sitaram
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Electrospun nanofiber Mats for ultrafast release of ondansetron2016Inngår i: Reactive & functional polymers, ISSN 1381-5148, E-ISSN 1873-166X, Vol. 99, s. 65-72Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Nanofiber mats or films are promising platforms that can offer unique opportunities in oromucosoal drug delivery. However, the conventional film forming technologies are unable to produce mats with unique internal microstructure and properties. Thus, the present study was aimed to develop electrospun nanofiber mats of a model drug -ondansetron hydrochloride (OND) for ultrafast drug release. Polyvinyl alcohol (PVA), a water soluble synthetic polymer was used in the preparation of nanofiber mats and casting film. The OND nanofiber mats and conventional films were prepared by electrospinning and casting methods, respectively. Different electrospinning process variables (feed rate, electric voltage and tip to collector distance) were investigated. Nanofiber mats and casted films were characterized using Scanning electron microscopy (SEM), Atomic force microscopy (AFM), Differential scanning calorimetry (DSC), Powder X-ray diffraction (PXRD), and Attenuated total reflection – Fourier transform infrared spectroscopy (ATR-FTIR). The folding endurance, drug content, wetting behaviour and disintegration properties and in-vitro drug release studies were also performed.The SEM and AFM had revealed that the nanofiber mats were formed with smooth uniform texture. Solid state studies indicated that the OND was in amorphous state and uniformly dispersed in PVA mats and a film. The electrospun nanofiber mat and casted film of OND showed sufficient mechanical properties. Wet sponge method suggested that OND nanofiber mats were simultaneously wetted and disintegrated within 10 s, which is ultrafast compared to casted films. The total amount of OND was released in 90 s (1.5 min) and 1800 s (30 min) from OND-PVA electrospun nanofiber mats and casted film, respectively. OND nanofiber mats can be promising alternatives to existing solid dosage forms for ultrafast release of drugs.

  • 361.
    Vuddanda, Parameswara Rao
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Velaga, Sitaram
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Singh, Sanjay
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Boswellic acid: medicinal use of an ancient herbal remedy2016Inngår i: Journal of Herbal Medicine, ISSN 2210-8033, Vol. 6, nr 4, s. 163-170Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Boswellic acid (BA) is an ancient herbal drug prescribed in the Indian traditional medicine systems (Ayurveda) for treatment of coughs, colds, hoarseness, bronchitis, asthma, dyspnea and diarrhea. Current research suggests it also has therapeutic potential in modern medical practice. Therefore, it is of interest to the research community to consolidate the preclinical and clinical findings on BA. The aim of this review was to comprehensively cover the plant sources, phytochemistry and physicochemical properties of BA along with its medicinal properties, safety, toxicity, and regulatory status. The review also discussed the challenges associated with drug delivery and some feasible approaches for addressing these. Four electronic databases (Scifinder, Unbound Medline, PubMed and Science Direct) and two internet search engines (Scirus and Google Scholar) were extensively searched without any time constraint.The many studies discussed in the review indicated therapeutic potential for BA in the treatment of a range of chronic diseases including arthritis, cancer, asthma and diabetes. It is hoped that this review will help researchers identify relevant research questions leading to the development of effective formulations and a better understanding of the safety of BA, with the aim of promoting it as a mainstream treatment for various diseases in clinical practice. 

  • 362.
    Weitoft, Gunilla Ringbäck
    et al.
    Socialstyrelsen.
    Haupt, Dan
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Nilsson, Lars G.
    NEPI.
    Adherence to oral type 2 diabetes mellitus drugs in Sweden2007Inngår i: Nordic meeting in Epidemiology and Register-based Health Research: June 18-19, 2007 in Gothenburg, Sweden, 2007Konferansepaper (Annet vitenskapelig)
  • 363.
    Wisten, Aase
    et al.
    Department of Internal Medicine, Sunderby Hospital, Lulea.
    Andersson, Staffan
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Forsberg, Håkan
    Department of Internal Medicine, Sunderby Hospital, Lulea.
    Krantz, P
    Messner, Torbjörn
    Department of Internal Medicine, Sunderby Hospital, Lulea.
    Sudden cardiac death in the young in Sweden: electrocardiogram in relation to forensic diagnosis2004Inngår i: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 255, nr 2, s. 213-220Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    OBJECTIVES: To study electrocardiogram (ECG) in relation to forensic diagnosis in young persons who suffered a sudden cardiac death (SCD) in Sweden during 1992-99. DESIGN: A register study of a national database of forensic medicine in Sweden, selecting all cases of SCD 15-35 years of age. In this group, 12-lead ECGs and clinical data were searched for in military conscription and medical records. The ECGs were re-analysed and classified according to the Minnesota code criteria. SETTING: The whole nation of Sweden. SUBJECTS: Sudden cardiac death victims (66 individuals), 15-35 years of age, where it was possible to obtain an ECG recording. RESULTS: We observed major or minor ECG abnormalities in 82% of the subjects. The most common changes were T wave abnormalities (35%), ST segment changes (32%) and conduction defects (20%). The ECGs were evaluated as pathological in 50% of the cases, more often in arrhythmogenic right ventricular cardiomyopathy (88%) and hypertrophic cardiomyopathy (82%). Cardiac-related symptoms were seen in 76% of the total group and there was a family history of a similar cardiac condition in 18%. CONCLUSIONS: Pathological ECGs were common in young SCD victims, in spite of being taken many years before death. An ECG could help identify prospective victims of SCD, and should always be taken in cases with possible cardiac-related symptoms or a family history of SCD. The pathological ECGs were often found in connection with routine screening at military enlistment for men, which raises the question of a routine screening in the young, including women

  • 364.
    Wälivaara, Britt-Marie
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Omvårdnad.
    Andersson, Staffan
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Axelsson, Karin
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Omvårdnad.
    Views on technology among people in need of health care at home2009Inngår i: International Journal of Circumpolar Health, ISSN 1239-9736, E-ISSN 2242-3982, Vol. 68, nr 2, s. 158-169Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives. The aim of this study was to describe how people in need of health care at home view technology.Study design. A qualitative approach was used based on qualitative interviews, followed by qualitative content analysis.Methods. District nurses (DNs) from 4 health care centres in Northern Sweden had access to different kinds of distance-spanning technology with mobile devices and who used it in their health care at home. Persons in whose home the technology was being used were asked to participate in an interview. The interviewed persons were selected consecutively. Results. The results fall into 2 categories: (1) The well-known technology at hospital is new at home, (2) the new technology opens up possibilities but it also has limitations, with seven adherent subcategories.Conclusions. The participants viewed the technology at home as something good and as something that could open up possibilities. At the same time, they placed the use of the technology in the hands of the staff which indicates some degree of dissociation from the technology. The importance of personal meetings between patient and caregiver was very clearly stressed even when distance meetings could be performed and accepted. The participants expressed immense trust in the nursing staff and considered them responsible for the new technology at home.

  • 365. Yang, Mingshi
    et al.
    Velaga, Sitaram
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Hovgaard, Lars
    Weert, Marco van de
    Frøkjær, Sven
    Characterization of salmon calcitonin in spray drying powder for inhalation2006Konferansepaper (Annet vitenskapelig)
  • 366.
    Yang, Mingshi
    et al.
    Danish University of Pharmaceutical, Department of Pharmaceutics and Analytical Chemistry.
    Velaga, Sitaram
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Yamamoto, Hiromitsu
    Gifu Pharmaceutical University, Japan, Laboratory of Pharmaceutical Engineering.
    Takeuchi, Hirofumi
    Gifu Pharmaceutical University, Japan, Laboratory of Pharmaceutical Engineering.
    Kawashima, Yoshiaka
    Aichi Gakuin University, Japan, School of Pharmacy.
    Hovgaard, Lars
    Danish University of Pharmaceutical, Department of Pharmaceutics and Analytical Chemistry.
    Weert, Marco van de
    Danish University of Pharmaceutical, Department of Pharmaceutics and Analytical Chemistry.
    Frokjaer, Sven
    Danish University of Pharmaceutical, Department of Pharmaceutics and Analytical Chemistry.
    Characterisation of salmon calcitonin in spray-dried powder for inhalation: effect of chitosan2007Inngår i: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 331, nr 2, s. 176-81Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Salmon calcitonin (sCT) powders suitable for inhalation, containing chitosan and mannitol as absorption enhancer and protection agent, respectively, were prepared using a spray-drying process. The effect of chitosan on physicochemical stability of sCT in the dry powder was investigated by different analytical techniques. High-performance liquid chromatography (HPLC) analysis indicated that sCT was chemically stable upon spray-drying. With the proportion of chitosan in spray-drying formulation being increased, dissolution of sCT from the dry powders was decreased both in phosphate buffer and acetate buffer. The thioflavine T fluorescence assay showed that no fibrils were present in the spray-dried powder. However, sCT partly fibrillated in the phosphate buffer, but not in acetate buffer. Fourier transform infrared (FTIR) spectra showed that the secondary structure of sCT was slightly changed in the dry powder, yet no aggregate signal was observed. Circular dichroism analysis indicated that the structure of sCT in an aqueous formulation was slightly altered by addition of chitosan. Nevertheless, recovery of sCT was not influenced by chitosan in the aqueous formulation as indicated by HPLC analysis. This study suggested that sCT, in absence of any additives, was stable during the spray-drying process under certain conditions. Addition of chitosan affects recovery of sCT from spray-dried powders, which may be due to formation of a partially irreversible complex between the protein and chitosan during the spray-drying process.

  • 367.
    Yu, Ji-Guo
    et al.
    Department of Surgical and Perioperative Sciences, Sports Medicine Unit and School of Sport Sciences, Umeå University.
    Bonnerud, Patrik
    Eriksson, Anders
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Stål, Per S.
    Department of Integrative Medical Biology, Section for Anatomy, Umeå University.
    Tegner, Yelverton
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Malm, Christer
    Umeå University, Department of Integrative Medical Biology, Winternet.
    Effects of Long Term Supplementation of Anabolic Androgen Steroids on Human Skeletal Muscle2014Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, nr 9, artikkel-id e105330Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The effects of long-term (over several years) anabolic androgen steroids (AAS) administration on human skeletal muscle are still unclear. In this study, seventeen strength training athletes were recruited and individually interviewed regarding self-administration of banned substances. Ten subjects admitted having taken AAS or AAS derivatives for the past 5 to 15 years (Doped) and the dosage and type of banned substances were recorded. The remaining seven subjects testified to having never used any banned substances (Clean). For all subjects, maximal muscle strength and body composition were tested, and biopsies from the vastus lateralis muscle were obtained. Using histochemistry and immunohistochemistry (IHC), muscle biopsies were evaluated for morphology including fiber type composition, fiber size, capillary variables and myonuclei. Compared with the Clean athletes, the Doped athletes had significantly higher lean leg mass, capillary per fibre and myonuclei per fiber. In contrast, the Doped athletes had significantly lower absolute value in maximal squat force and relative values in maximal squat force (relative to lean body mass, to lean leg mass and to muscle fiber area). Using multivariate statistics, an orthogonal projection of latent structure discriminant analysis (OPLS-DA) model was established, in which the maximal squat force relative to muscle mass and the maximal squat force relative to fiber area, together with capillary density and nuclei density were the most important variables for separating Doped from the Clean athletes (regression = 0.93 and prediction = 0.92, p<0.0001). In Doped athletes, AAS dose-dependent increases were observed in lean body mass, muscle fiber area, capillary density and myonuclei density. In conclusion, long term AAS supplementation led to increases in lean leg mass, muscle fiber size and a parallel improvement in muscle strength, and all were dose-dependent. Administration of AAS may induce sustained morphological changes in human skeletal muscle, leading to physical performance enhancement.

  • 368.
    Zühlke, Per
    et al.
    Winternet.
    Lysholm, Jack
    Winternet.
    Stene, Fredrik
    Sundbybergs Rehab och Fysioterapi.
    Tegner, Yelverton
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Postural stability after concussion in ice hockey players2008Inngår i: Svensk idrottsmedicinsk förenings vårmöte: Stockholm 2008, Svensk idrottsmedicinsk förening , 2008Konferansepaper (Annet vitenskapelig)
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