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  • 451.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Brain cuncussion in ice hockey: a suggestion for uniform treatment2000In: Safety in ice hockey: IIHF, International Symposium on Medecine and Science in Ice Hockey on the occasion of the 8th Ice Hockey World Chamionship / [ed] Nicola Biasca; Wolf-Dieter Montag; Christian Gerber, Zurich: IIHF , 2000, p. 86-89Conference paper (Refereed)
  • 452.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Commotio inom idrotten2004In: 7th Scandinavian Congress of Medicine and Science in Sports: Stockholm, March 25-27, 2004, Solna: Karolinska institutet , 2004Conference paper (Other academic)
  • 453.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Concussion experience: swedish elite ice hockey league2001In: British Journal of Sports Medicine, ISSN 0306-3674, E-ISSN 1473-0480, Vol. 35, no 5, p. 376-7Article in journal (Refereed)
  • 454.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Concussion in swedish elite ice hockey2001In: International Symposium on Concussion in Sport, Vienna, Austria on November 2 and 3, 2001, 2001Conference paper (Other academic)
  • 455.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Concussion in swedish elite ice hockey2004In: Safety in ice hockey, fourth volume: [papers presented at the Fourth Symposium on Ice Hockey held 5 - 6 May 2002 in Pittsburgh, Pennsylvania] / [ed] David J. Pearsall; Alan B. Ashare, West Conshohocken, Pa: ASTM International, 2004Conference paper (Other academic)
  • 456.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Concussion in swedish elite ice hockey: a 20 years experience2004In: British Journal of Sports Medicine, ISSN 0306-3674, E-ISSN 1473-0480, Vol. 38, no 5, p. 663-664Article in journal (Refereed)
  • 457.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Head injuries2003In: Football medicine, London: Martin Dunitz, 2003, p. 229-240Chapter in book (Other academic)
  • 458.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Hovedskador2001In: Fotballmedisin, Oslo: Norges fotballforbund , 2001, p. 203-14Chapter in book (Other academic)
  • 459. Tegner, Yelverton
    Huvudskador1998In: Fotbollsmedicin / [ed] Jan Ekstrand, Jon Karlsson, Solna: Svenska fotbollsförbundet , 1998, p. 197-210Chapter in book (Other academic)
  • 460.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Injury prevention in swedish ice hockey2005In: Final program : 1st World Congress on Sports Injury Prevention: Holmenkollen Park Hotel, Oslo, Norway, June 23-25, 2005, Oslo Sports trauma research Center , 2005Conference paper (Other academic)
  • 461.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Injury registration for concussion registration2004In: British Journal of Sports Medicine, ISSN 0306-3674, E-ISSN 1473-0480, Vol. 38, no 5, p. 663-Article in journal (Refereed)
  • 462.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Ishockey: skallskador i Sverige2007In: Riksstämman Stockholm 2007: vetenskap, utbildning, kvalitet : 28 november- 30 november, Stockholm: Svenska läkaresällskapet , 2007, p. 66-Conference paper (Other academic)
  • 463.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Magnetkameran: en onödig pryl för meniskdiagnostiken?2002In: Program & sammanfattningar, [59]: Svenska mässan, Göteborg, 27-29 november 2002, Stockholm: Svenska läkaresällskapet , 2002Conference paper (Other academic)
  • 464.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Osteoarthritis of the knee in the elderly2010In: Vol. 21, no SupplArticle in journal (Refereed)
  • 465.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Serious spinal injuries in Swedish ice hockey2000In: Safety in ice hockey: third volume / [ed] Alan B. Ashare, West Conshohocken, Pa: ASTM International, 2000, p. 164-172Conference paper (Refereed)
  • 466.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Back, Birgitta
    Gilenstam, Kajsa
    Umeå universitet, Kirurgisk och perioperativ vetenskap, idrottsmedicin.
    Holm, Anette
    Skadepanoramat i svensk elitishockey2000In: Program & sammanfattningar. [57]: Svenska mässan, Göteborg, 29 november-1 december 2000, Stockholm: Svenska läkaresällskapet , 2000Conference paper (Other academic)
  • 467.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Biasca, Nicola
    Spital Oberengadin, Orthopaedic Clinic.
    International sports injury system: ISIS2004In: Safety in ice hockey, fourth volume: [papers presented at the Fourth Symposium on Ice Hockey held 5 - 6 May 2002 in Pittsburgh, Pennsylvania] / [ed] David J. Pearsall; Alan B. Ashare, West Conshohocken, Pa: ASTM International, 2004Conference paper (Other academic)
  • 468.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Gustafsson, Bengt
    Idrottskliniken, Solna.
    Forssblad, Magnus
    Captio Artro Clinic, Stockholm.
    Lundgren, Lars
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Näsmark, Annica
    Hjärnskakning inom fotbollen2007In: Nya mål : fotbollsmagasinet, ISSN 1100-0201, no 4, p. 44-46Article in journal (Other (popular science, discussion, etc.))
  • 469.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Gustafsson, Bengt
    Idrottskliniken, Solna.
    Forssblad, Magnus
    Captio Artro Clinic, Stockholm.
    Lundgren, Lars
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Sölveborn, Sven Anders
    Ystads lasarett, Ortopedkliniken.
    Hjärnskakning och idrott: nya riktlinjer för handledning2007In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 104, no 16, p. 1220-1223Article in journal (Other academic)
  • 470.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Gustafsson, Bengt
    Idrottskliniken, Solna.
    Forssblad, Magnus
    Captio Artro Clinic, Stockholm.
    Lundgren, Lars
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Sölveborn, Sven Anders
    Ortopedkliniken Lasarettet Ystad.
    Riktlinjerna bör gälla även boxare!2007In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 104, no 22, p. 1715-1716Article in journal (Other academic)
  • 471.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Gustafsson, Bengt
    Idrottskliniken, Solna.
    Lundgren, Lars
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Nya riktlinjer för handläggning av hjärnskakningar2007In: Hockey, ISSN 0345-4347, p. 38-41Article in journal (Other (popular science, discussion, etc.))
  • 472.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Gustafsson, Bengt
    Idrottskliniken, Solna.
    Lundgren, Lars
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Nya riktlinjer för handläggning av hjärnskakningar2007In: Nedsläpp, no 3, p. 12-15Article in journal (Other (popular science, discussion, etc.))
  • 473.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Gustafsson, Bengt
    Idrottskliniken, Solna.
    Lundgren, Lars
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Forssblad, Magnus
    Captio Artro Clinic, Stockholm.
    Hjärnskakning inom idrotten2007In: Idrottsskador: frontlinjen inom behandling och rehabilitering, Stockholm: Centrum för idrottsforskning, CIF , 2007, p. 11-22Chapter in book (Other academic)
  • 474.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Gustafsson, Bengt
    Idrottskliniken, Solna.
    Lundgren, Lars
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Forssblad, Magnus
    Captio Artro Clinic, Stockholm.
    Näsmark, Annica
    Sport och rehabkliniken, Åkeshovshallen, Bromma.
    Hjärnskakning inom fotbollen: nya riktlinjer för handläggning2007Other (Other (popular science, discussion, etc.))
  • 475.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Gustafsson, Bengt
    Idrottskliniken, Solna.
    Lundgren, Lars
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Forssblad, Magnus
    Captio Artro Clinic, Stockholm.
    Sölveborn, Sven Anders
    Ortopedkliniken, Ystads lasarett.
    Hjärnskakning och idrott: nya riktlinjer för handläggning inom idrotten2007In: Idrott och kunskap, ISSN 1652-6961Article in journal (Other (popular science, discussion, etc.))
  • 476.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Gustafsson, Bengt
    Idrottskliniken, Solna.
    Lundgren, Lars
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Forssblad, Magnus
    Captio Artro Clinic, Stockholm.
    Sölveborn, Sven Anders
    Ortopedkliniken, Ystads lasarett.
    Risken obefintlig, återhämtningen optimal2007In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 104, no 47, p. 3560-Article in journal (Other academic)
  • 477.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Gustafsson, Bengt
    Idrottskliniken, Solna.
    Lundgren, Lars
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Sölveborn, Sven Anders
    Ortopedkliniken, Ystads lasarett.
    Erichsen, Jessica
    Kirurgi- och ortopedkliniken, Kungälvs sjukhus.
    Handläggning av hjärnskakningar inom handbollen2007In: Göteborgshandbollen, Vol. 14, no 3, p. 16-21Article in journal (Other (popular science, discussion, etc.))
  • 478.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Gustafsson, Bengt
    Idrottskliniken, Solna.
    Lundgren, Lars
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Sölveborn, Sven Anders
    Ortopedkliniken, Ystads lasarett.
    Erichsen, Jessica
    Kirurgi- och ortopedkliniken, Kungälvs sjukhus.
    Hjärnskakning2007Other (Other (popular science, discussion, etc.))
  • 479.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Gustavsson, Bengt
    Neuropsykologiska tester styr återgång efter skada: rapport från Second international symposium on concussion in sport, Prag 20042005In: Svensk idrottsmedicin, ISSN 1103-7652, no 2, p. 34-36Article in journal (Other academic)
  • 480.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Jacobson, Inger
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Skadepanoramat inom svensk damfotboll samt eventuella geografiska skillnader2001In: Forskningsrapporter / Centrum för idrottsforskning, Stockholm: Centrum för idrottsforskning, CIF , 2001, p. 68-Chapter in book (Other academic)
  • 481.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Lundgren, Lars
    Step in, Sjukgymnastiken.
    10-årsuppföljning av konservativt behandlade patienter med främre korsbandsskada2001In: Forskningsrapporter / Centrum för idrottsforskning, Stockholm: Centrum för idrottsforskning, CIF , 2001, p. 69-Chapter in book (Other academic)
  • 482.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Lundgren, Lars
    Step in, Sjukgymnastiken.
    Knee function 10 years after non-operatiely treated anterior cruciate ligament injury with special focus on the role of meniscus lesions2004In: Svensk ortopedisk förening 60:e årsmöte 17-20 augusti 2004 i Gävle, Svensk ortopedisk förening , 2004Conference paper (Other academic)
  • 483.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Lysholm, Jack
    FoU-enheten, Västerbottens läns landsting.
    Lysholm Score för ligamentskada i knä2009In: Svensk idrottsmedicin, ISSN 1103-7652, Vol. 28, no 3, p. 5-7Article in journal (Other academic)
  • 484.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Lysholm, Jack
    Umeå universitet.
    The Development of Functional Assessment of the Knee2010In: Vol. 21, no Suppl.Article in journal (Refereed)
  • 485.
    Tegner, Yelverton
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Lysholm, Jack
    Winternet.
    Stene, Fredrik
    Winternet.
    Forskning om idrottscommotio2004In: Svensk idrottsmedicin, ISSN 1103-7652, Vol. 23, no 1, p. 23-24Article in journal (Other academic)
  • 486.
    Tengman, E.
    et al.
    Department of Community Medicine and Rehabilitation, Section for Physiotherapy, Umeå University.
    Olofsson, L. Brax
    Department of Community Medicine and Rehabilitation, Section for Physiotherapy, Umeå University.
    Nilsson, K.G.
    Department of Orthopaedics, Surgical and Perioperative Sciences, Umeå University.
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Lundgren, L.
    Luleå tekniska universitet.
    Häger, C.K.
    Department of Community Medicine and Rehabilitation, Section for Physiotherapy, Umeå University.
    Anterior cruciate ligament injury after more than 20 years: I. Physical activity level and knee function2014In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 24, no 6, p. e491-e500Article in journal (Refereed)
    Abstract [en]

    Little is known about physical activity level and knee function including jump capacity and fear of movement/reinjury more than 20 years after injury of the anterior cruciate ligament (ACL). Seventy persons with unilateral ACL injury participated (23 ± 2 years post-injury): 33 treated with physiotherapy in combination with surgical reconstruction (ACLR), and 37 treated with physiotherapy alone (ACLPT). These were compared with 33 age- and gender-matched controls. Assessment included knee-specific and general physical activity level [Tegner activity scale, International Physical Activity Questionnaire (IPAQ)], knee function [Lysholm score, Knee injury and Osteoarthritis Outcome Score (KOOS)], jump capacity (one-leg hop, vertical jump, side hops), and fear of movement/reinjury [Tampa Scale for Kinesiophobia (TSK)]. Outcomes were related to degree of osteoarthritis (OA). ACL-injured had lower Lysholm, KOOS, and Tegner scores than controls (P < 0.001), while IPAQ score was similar. ACL-injured demonstrated inferior jump capacity in injured compared with noninjured leg (6–25%, P < 0.001–P = 0.010 in the different jumps), while noninjured leg had equal jump capacity as controls. ACL groups scored 33 ± 7 and 32 ± 7 of 68 on TSK. Lower scores on Lysholm and KOOS symptom were seen for persons with moderate-to-high OA than for no-or-low OA, while there were no differences for physical activity and jump capacity. Regardless of treatment, there are still negative knee-related effects of ACL injury more than 20 years later.

  • 487.
    Trubetskaya, Anna
    et al.
    Luleå University of Technology, Department of Engineering Sciences and Mathematics, Energy Science.
    Beckmann, Gert
    Retsch Technology GmbH.
    Wadenbäck, Johan
    Amager power plant, HOFOR A/S.
    Holm, Jens Kai
    DONG Energy Thermal Power A/S.
    Velaga, Sitaram
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Weber, Roman
    Institute of Energy Processes Engineering and Fuel Technology, Clausthal University of Technology.
    One way of representing the size and shape of biomass particles in combustion modeling2017In: Fuel, ISSN 0016-2361, E-ISSN 1873-7153, Vol. 206, p. 675-683Article, book review (Refereed)
    Abstract [en]

    This study aims to provide a geometrical description of biomass particles that can be used in combustion models. The particle size of wood and herbaceous biomass was compared using light microscope, 2D dynamic imaging, laser diffraction, sieve analysis and focused beam reflectance measurement. The results from light microscope and 2D dynamic imaging analysis were compared and it showed that the data on particle width, measured by these two techniques, were identical. Indeed, 2D dynamic imaging was found to be the most convenient particle characterization method, providing information on both the shape and the external surface area. Importantly, a way to quantify all three dimensions of biomass particles has been established. It was recommended to represent a biomass particle in combustion models as an infinite cylinder with the volume-to-surface ratio (V/A) measured using 2D dynamic imaging.

  • 488.
    Valdés, Karina
    et al.
    Departamento de Ciencias y Tecnología Farmacéutica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago.
    Morales, Javier O.
    Rodríguez, Lennin
    Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo.
    Günther, German
    Departamento de Química Orgánica y Fisicoquímica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago.
    Potential use of nanocarriers with pentacyclic triterpenes in cancer treatments2016In: Nanomedicine, ISSN 1743-5889, E-ISSN 1748-6963, Vol. 12, no 23, p. 3139-3156Article in journal (Refereed)
    Abstract [en]

    Ursolic, oleanolic and betulinic acids are representative pentacyclic triterpenoids found in various plants and fruits. Despite having marked antitumor potentials, the very poor water solubility of these triterpenes hinders treatment development. Nanotechnology can enhance solubility, stability, bioavailability and phytochemical delivery, improving the therapeutic efficiency of triterpenes. This review focuses on the formulation, characterization and in vitro/in vivo evaluation of several delivery nanosystems used to enhance the physicochemical properties of ursolic, oleanolic and betulinic acids

  • 489.
    Vedung, Fredrik
    et al.
    Uppsala University, Dept Neurosurg, Uppsala, Sweden.
    Hanni, Sofie
    Uppsala University, Surg Sci, Uppsala, Sweden .
    Tegner, Yelverton
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Johansson, Jakob
    Uppsala University, Surg Sci, Uppsala, Sweden .
    Marklund, Niklas
    Uppsala University, Neurosci, Neurosurg, Uppsala, Sweden .
    CONCUSSION INCIDENCE IN SWEDISH ELITE SOCCER2018In: Journal of Neurotrauma, ISSN 0897-7151, E-ISSN 1557-9042, Vol. 35, no 16, p. A270-A270Article in journal (Refereed)
  • 490.
    Velaga, Sitaram
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Djuris, Jelena
    Department of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy.
    Cvijic, Sandra
    Department of Pharmaceutical Technology and Cosmetology, University of Belgrade-Faculty of Pharmacy.
    Rozou, Stavroula
    Elpen Pharmaceutical Co..
    Russo, Paola
    Department of Pharmacy, University of Salerno.
    Colombo, Gaia
    Department of Life Sciences and Biotechnology, University of Ferrara.
    Rossi, Alessandra
    Food and Drug Department, University of Parma.
    Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products2018In: European Journal of Pharmaceutical Sciences, ISSN 0928-0987, E-ISSN 1879-0720, Vol. 113, p. 18-28Article in journal (Refereed)
    Abstract [en]

    In vitro dissolution testing is routinely used in the development of pharmaceutical products. Whilst the dissolution testing methods are well established and standardized for oral dosage forms, i.e. tablets and capsules, there are no pharmacopoeia methods or regulatory requirements for testing the dissolution of orally inhaled powders. Despite this, a wide variety of dissolution testing methods for orally inhaled powders has been developed and their bio-relevance has been evaluated.

    The review provides an overview of the in vitro dissolution methodologies for dry inhalation products, with particular emphasis on dry powder inhaler, where the dissolution behavior of the respirable particles can have a role on duration and absorption of the drug. Dissolution mechanisms of respirable particles as well as kinetic models have been presented. A more recent bio-relevant dissolution set-ups and media for studying inhalation biopharmaceutics were also reviewed. In addition, factors affecting interplay between dissolution and absorption of deposited particles in the context of biopharmaceutical considerations of inhalation products were examined.

  • 491.
    Velaga, Sitaram
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Nikjoo, Dariush
    Luleå University of Technology, Department of Engineering Sciences and Mathematics, Material Science.
    Rao Vuddanda, Parameswara
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Drying Kinetics of Polymeric Films: theoretical and experimental studies2016Conference paper (Refereed)
  • 492.
    Velaga, Sitaram
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Nikjoo, Dariush
    Luleå University of Technology, Department of Engineering Sciences and Mathematics, Material Science.
    Rao Vuddanda, Parameswara
    Luleå University of Technology, Department of Health Sciences, Medical Science. Department of Pharmaceutics, UCL School of Pharmacy, University College London.
    Experimental Studies and Modeling of the Drying Kinetics of Multicomponent Polymer Films2018In: AAPS PharmSciTech, ISSN 1530-9932, E-ISSN 1530-9932, Vol. 19, no 1, p. 425-435Article in journal (Refereed)
    Abstract [en]

    The process of drying thin polymer films is an important operation that influences the film structure and solid state, and the stability of the product. The purpose of this work was to study and model the drying kinetics of multicomponent films based on two polymers: hydroxypropyl methylcellulose (HPMC, amorphous) and polyvinyl alcohol (PVA, semicrystalline). The isothermal drying kinetics of the films at different temperatures (40, 60, and 80°C) were studied using thermo-gravimetric analysis (TGA) and convection oven methods. Solid-state characterization tools used in the study included polarization and hot-stage microscopy, scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). The drying kinetics of HPMC and PVA films in the TGA apparatus and convection oven were comparable. The three-parameter (Wmax, τ, n) Hill equation successfully modeled the experimental drying kinetics. The time factor τ in the Hill equation nicely explained two drying phases in the films. Solid-state phase changes occurring in the films during dehydration had a bearing on the drying kinetics and mechanisms. TGA can be used as a simple tool to determine the end points in drying processes using ovens or tunnels. The three-parameter Hill equation explained the drying kinetics and diffusion mechanisms of the solvent through the polymer films for the first time. This study advances our understanding of film drying, in particular for pharmaceutically relevant thin films.

  • 493.
    Velaga, Sitaram
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Vangala, Venu R.
    Basavoju, Srinivas
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Boström, Dan
    Umeå university.
    Polymorphism in acesulfame sweetener: structure-property and stability relationships of bending and brittle crystals2010In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 46, no 21, p. 3562-3564Article in journal (Refereed)
    Abstract [en]

    Acesulfame is found to exist in two crystalline forms of which Form I (needles) shows bending upon mechanical stress. Crystal structures explain their mechanical response. This is the first case of aliphatic organic compounds featuring a bending phenomenon. Form I is physically more stable than Form II in ambient conditions.

  • 494.
    Vidman, Åsa
    Luleå University of Technology, Department of Health Sciences, Health and Rehab.
    Begreppet "social omsorg" från olika perspektiv1992In: Social omsorg, ISSN 0280-848X, no 6, p. 8-11Article in journal (Other academic)
  • 495.
    Vijayakumar, Mahalingam Rajamanickam
    et al.
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Kosuru, Ramoji
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Vuddanda, Parameswara Rao
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Singh, Sanjay Kumar
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Singh, Sanjay
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Trans resveratrol loaded DSPE PEG 2000 coated liposomes: An evidence for prolonged systemic circulation and passive brain targeting2016In: Journal of Drug Delivery Science and Technology, ISSN 1773-2247, Vol. 33, p. 125-135Article in journal (Refereed)
    Abstract [en]

    Trans resveratrol (RSV) is a natural molecule proved for cardioprotective effects, vasodilation, anti-inflammatory, cancer preventive and therapeutic activities devoid of any potential side effects. Recently, anti cancer potential against glioma cells were also reported with proven molecular mechanisms. However, the therapeutic application of RSV in clinical disease management is restricted because of its rapid elimination from systemic circulation and thereby low biological half life in mammals. Therefore, the main objective of this study was to improve the systemic circulation and biological half life of RSV using DSPE PEG 2000 decorated (PEGylated) liposomes. Moreover, brain distribution of RSV loaded PEGylated liposomes (RSV-PEG-Lipo) and non-PEGylated liposomes (RSV-Lipo) was also evaluated for proving their passive brain targeting ability. In vitro drug release of both liposomes was found to be sustained up to 48 h. RSV-PEG-Lipo showed higher area under the curve, plasma half life and mean residence time and lower volume of distribution and clearance than that of pristine RSV solution and RSV-Lipo. Pharmaokinetics results clearly indicated that the RSV-PEG-Lipo will be promising tool for enhancing plasma half life and prolong the systemic circulation of RSV. Brain distribution studies revealed that the liposomal formulations can be applied as an effective tool for passive brain targeting useful in the treatment of glioma.

  • 496.
    Vijayakumar, Mahalingam Rajamanickam
    et al.
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Kumari, Lakshmi
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Patel, Krishna Kumar
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Vuddanda, Parameswara Rao
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Vajanthri, Kiran Yellappa
    School of Biomedical Engineering, Indian Institute of Technology (Banaras Hindu University).
    Mahto, Sanjeev Kumar
    School of Biomedical Engineering, Indian Institute of Technology (Banaras Hindu University).
    Singh, Sanjay
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Intravenous administration of trans-resveratrol-loaded TPGS-coated solid lipid nanoparticles for prolonged systemic circulation, passive brain targeting and improved in vitro cytotoxicity against C6 glioma cell lines2016In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 6, no 55, p. 50336-50348Article in journal (Refereed)
    Abstract [en]

    trans-Resveratrol (RSV), a natural molecule isolated from red wine, is widely known for several therapeutic potentials. RSV is proved for cardioprotective, vasodilation, anti-inflammatory, and anticancer effects. Recently, anticancer potential against glioma cells has also been reported. However, the clinical application of RSV in glioma treatment is largely limited because of its rapid metabolism and elimination from systemic circulation thereby exhibiting low biological half-life and poor brain distribution as well. Therefore, the main objective of this study was to enhance the circulation time, biological half-life and passive brain targeting of RSV using D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-coated solid lipid nanoparticles (RSV-TPGS-SLN). RSV-TPGS-SLN formulations were prepared by a solvent emulsification evaporation method and evaluated for several nanoparticulate characteristics. In vitro anticancer potential and cellular internalization of nanoparticles were also investigated in C6 glioma cell lines. Pharmacokinetics and biodistribution studies were carried out following intravenous administration in healthy Charles Foster rats. RSV-TPGS-SLN showed significantly higher in vitro cytotoxicity against C6 glioma cell lines and excellent cellular internalization. RSV-TPGS-SLN showed 11.12 and 9.37 times higher area under the curve and plasma half-life than RSV solution, respectively. Moreover, brain distribution of RSV-TPGS-SLN was found to be 9.23 times higher in comparison to that of RSV alone. Thus, we anticipate that the RSV-TPGS-SLN formulation can be applied as a potential tool for improving circulation time, biological half-life and passive brain targeting of RSV, thereby being immensely useful in the treatment of glioma.

  • 497.
    Vuddanda, Parameswara Rao
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science. Department of Pharmaceutics, UCL School of Pharmacy, University College London, London, United Kingdom.
    Alomari, Mustafa
    Department of Pharmaceutics, UCL School of Pharmacy, University College London.
    Dodoo, Cornelius C.
    Department of Pharmaceutics, UCL School of Pharmacy, University College London.
    Trenfield, Sarah J.
    Department of Pharmaceutics, UCL School of Pharmacy, University College London.
    Velaga, Sitaram
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Basit, Abdul W.
    Department of Pharmaceutics, UCL School of Pharmacy, University College London.
    Gaisford, Simon
    Department of Pharmaceutics, UCL School of Pharmacy, University College London.
    Personalisation of warfarin therapy using thermal ink-jet printing2018In: European Journal of Pharmaceutical Sciences, ISSN 0928-0987, E-ISSN 1879-0720, Vol. 117, p. 80-87Article in journal (Refereed)
    Abstract [en]

    Warfarin is a widely used anticoagulant that is critical in reducing patient morbidity and mortality associated with thromboembolic disorders. However, its narrow therapeutic index and large inter-individual variability can lead to complex dosage regimes. Formulating warfarin as an orodispersible film (ODF) using thermal ink-jet (TIJ) printing could enable personalisation of therapy to simplify administration. Commercial TIJ printers are currently unsuitable for printing the milligram dosages, typically required for warfarin therapy. As such, this study aimed to modify a commercial TIJ printing system to formulate personalised warfarin ODFs containing therapeutic dosages. A TIJ printer was modified successfully with the printer functionality intact; the substrate (paper) rolling mechanism of the printer was replaced by printing onto a stationary stage. Free film substrates were composed of hydroxypropyl methylcellulose (20%w/w) and glycerol (3%w/w). The resulting ODFs were characterised for morphology, disintegration, solid-state properties and drug content. Printed film stability was assessed at 40 °C/75% relative humidity for 30 days. Therapeutic warfarin doses (1.25 and 2.5 mg) were successfully printed onto the film substrates. Excellent linearity was observed between the theoretical and measured dose by changing the warfarin feed concentration (R2 = 0.9999) and length of the print objective, i.e. the Y-value, (R2 = 0.9998). Rapid disintegration of the ODFs was achieved. As such, this study successfully formulated personalised warfarin ODFs using a modified TIJ printer, widening the range of applications for TIJ printing to formulate narrow therapeutic index drugs.

  • 498.
    Vuddanda, Parameswara Rao
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Mathew, Aji P.
    Luleå University of Technology, Department of Engineering Sciences and Mathematics, Material Science.
    Velaga, Sitaram
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Electrospun nanofiber Mats for ultrafast release of ondansetron2016In: Reactive & functional polymers, ISSN 1381-5148, E-ISSN 1873-166X, Vol. 99, p. 65-72Article in journal (Refereed)
    Abstract [en]

    Nanofiber mats or films are promising platforms that can offer unique opportunities in oromucosoal drug delivery. However, the conventional film forming technologies are unable to produce mats with unique internal microstructure and properties. Thus, the present study was aimed to develop electrospun nanofiber mats of a model drug -ondansetron hydrochloride (OND) for ultrafast drug release. Polyvinyl alcohol (PVA), a water soluble synthetic polymer was used in the preparation of nanofiber mats and casting film. The OND nanofiber mats and conventional films were prepared by electrospinning and casting methods, respectively. Different electrospinning process variables (feed rate, electric voltage and tip to collector distance) were investigated. Nanofiber mats and casted films were characterized using Scanning electron microscopy (SEM), Atomic force microscopy (AFM), Differential scanning calorimetry (DSC), Powder X-ray diffraction (PXRD), and Attenuated total reflection – Fourier transform infrared spectroscopy (ATR-FTIR). The folding endurance, drug content, wetting behaviour and disintegration properties and in-vitro drug release studies were also performed.The SEM and AFM had revealed that the nanofiber mats were formed with smooth uniform texture. Solid state studies indicated that the OND was in amorphous state and uniformly dispersed in PVA mats and a film. The electrospun nanofiber mat and casted film of OND showed sufficient mechanical properties. Wet sponge method suggested that OND nanofiber mats were simultaneously wetted and disintegrated within 10 s, which is ultrafast compared to casted films. The total amount of OND was released in 90 s (1.5 min) and 1800 s (30 min) from OND-PVA electrospun nanofiber mats and casted film, respectively. OND nanofiber mats can be promising alternatives to existing solid dosage forms for ultrafast release of drugs.

  • 499.
    Vuddanda, Parameswara Rao
    et al.
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Velaga, Sitaram
    Luleå University of Technology, Department of Health Sciences, Medical Science.
    Singh, Sanjay
    Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanas.
    Boswellic acid: medicinal use of an ancient herbal remedy2016In: Journal of Herbal Medicine, ISSN 2210-8033, Vol. 6, no 4, p. 163-170Article in journal (Refereed)
    Abstract [en]

    Boswellic acid (BA) is an ancient herbal drug prescribed in the Indian traditional medicine systems (Ayurveda) for treatment of coughs, colds, hoarseness, bronchitis, asthma, dyspnea and diarrhea. Current research suggests it also has therapeutic potential in modern medical practice. Therefore, it is of interest to the research community to consolidate the preclinical and clinical findings on BA. The aim of this review was to comprehensively cover the plant sources, phytochemistry and physicochemical properties of BA along with its medicinal properties, safety, toxicity, and regulatory status. The review also discussed the challenges associated with drug delivery and some feasible approaches for addressing these. Four electronic databases (Scifinder, Unbound Medline, PubMed and Science Direct) and two internet search engines (Scirus and Google Scholar) were extensively searched without any time constraint.The many studies discussed in the review indicated therapeutic potential for BA in the treatment of a range of chronic diseases including arthritis, cancer, asthma and diabetes. It is hoped that this review will help researchers identify relevant research questions leading to the development of effective formulations and a better understanding of the safety of BA, with the aim of promoting it as a mainstream treatment for various diseases in clinical practice. 

  • 500.
    Wallin, Gisela van der Ster
    et al.
    Department of Nutrition, University of Uppsala.
    Norring, Claes E.A.
    Eating Disorder Unit Department of Psychiatry Uppsala University.
    Wiklund, Maria Lennernäs
    National Food Administration, Uppsala.
    Holmgren, Sven
    Eating Disorder Unit Department of Psychiatry Uppsala University.
    Food selection in anorectics and bulimics: Food items, nutrient content and nutrient density1995In: Journal of the American College of Nutrition (Print), ISSN 0731-5724, E-ISSN 1541-1087, Vol. 14, no 3, p. 271-277Article in journal (Refereed)
    Abstract [en]

    The food selection and nutrient intake were investigated in women with anorexia nervosa, bulimia nervosa and controls. Methods Dietary data was obtained by 24-hour recall, and 7-day recording among eating disordered patients, and by 3-day registration among controls. Results: The intake of energy and nutrients differed from controls, as expected, while there were no differences between anorectics and bulimics in this respect, except for iron. There were only minor differences among the three groups studied with respect to nutrient density. Energy percentages of protein, fat, and carbohydrates, were similar in all groups, but a subdivision of the macronutrients into respective sources showed that bulimics had a lower relative and absolute intake of carbohydrates from bread and cereals than anorectics and controls. Conclusion: Eating disorder patients, despite their marginal food intake, still met the minimum requirement for most nutrients according to the Nordic Nutrient recommendations. Abbreviations: AN = anorexia nervosa, AN/BN = anorectic bulimics, BMI = body mass index, BN = bulimia nervosa, DSM-III-R = Diagnostic and Statistical Manual of Mental Disorders, ED = eating disorder, NNR = Nordic Nutrient Recommendation

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