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  • 51.
    Briggs, Karen K.
    et al.
    Steadman Hawkins research foundation, Basic science research, Vail.
    Lysholm, Jack
    Winternet.
    Tegner, Yelverton
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Rodkey, William G.
    Steadman Hawkins research foundation, Basic science research, Vail.
    Steadman, J. Richard
    Steadman Hawkins research foundation, Basic science research, Vail.
    25 years later: the reliability, validity and responsiveness of the Lysholm score and Tegner activity scale for anterior cruciate ligament injury of tne knee2008Inngår i: Knee Surgery, Sports Traumatology, Arthroscopy, ISSN 0942-2056, E-ISSN 1433-7347, Vol. 16, nr Suppl. 1, s. S34-Artikkel i tidsskrift (Annet vitenskapelig)
  • 52.
    Brogårdh, Christina
    et al.
    Skåne University Hospital, Lund.
    Flansbjer, Ulla-Britt
    Lund University.
    Lexell, Jan
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    No effects of whole-body vibration training on muscle strength and gait performance in persons with late effects of polio: a pilot study2010Inngår i: Archives of Physical Medicine and Rehabilitation, ISSN 0003-9993, E-ISSN 1532-821X, Vol. 91, nr 9, s. 1474-1477Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    ObjectiveTo evaluate the feasibility and possible effects of whole-body vibration (WBV) training on muscle strength and gait performance in people with late effects of polio.DesignA case-controlled pilot study with assessments before and after training.SettingA university hospital rehabilitation department.ParticipantsPeople (N=5; 3 men, 2 women; mean age, 64±6.7y; range, 55-71y) with clinically and electrophysiologically verified late effects of polio.InterventionsAll participants underwent 10 sessions of supervised WBV training (standing with knees flexed 40°-55° up to 60 seconds per repetition and 10 repetitions per session twice weekly for 5 weeks).Main Outcome MeasuresIsokinetic and isometric knee muscle strength (dynamometer), and gait performance (Timed Up & Go, Comfortable Gait Speed, Fast Gait Speed, and six-minute walk tests).ResultsAll participants completed the 5 weeks of WBV training, with no discernible discomfort. No significant changes in knee muscle strength or gait performance were found after the WBV training period.ConclusionsThis pilot study did not show any significant improvements in knee muscle strength and gait performance following a standard protocol of WBV training. Thus, the results do not lend support to WBV training for people with late effects of polio.

  • 53.
    Brogårdh, Christina
    et al.
    Umeå University, Rehabilitation Medicine, Department of Community Medicine and Rehabilitation.
    Flansbjer, Ulla-Britt
    Department of Rehabilitation, Lund University Hospital, Sweden.
    Lexell, Jan
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    What is the long term benefit of constraint induced movement therapy?: a 4-year follow-up2009Inngår i: Clinical Rehabilitation, ISSN 0269-2155, E-ISSN 1477-0873, Vol. 23, nr 5, s. 418-423Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: To evaluate the long-term benefits of constraint-induced movement therapy in chronic stroke.Design: A four-year follow-up after constraint-induced group therapy assessing arm and hand function and self-reported daily hand use.Subjects: Fourteen post-stroke individuals (six women and eight men; mean age 59.6 ± 12.7 years, range 23-75 years) with mild to moderate impairments of hand function.Outcome measures: The Sollerman hand function test and the Motor Activity Log test.Results: Four years after constraint-induced group therapy the participants had maintained their hand function, as measured by the Sollerman hand function test. The self-reported use and quality of movements of the more affected hand, as measured by the Motor Activity Log test, had decreased compared to post-treatment and three months follow-up (P < 0.01), but was still significantly higher than pre-treatment (P < 0.05).Conclusion: There seems to be a long-term benefit of constraint-induced group therapy. Hand function was maintained over time and daily hand use had increased compared to pre-treatment. To provide guidelines about the clinical use of constraint-induced movement therapy further, larger and controlled studies are needed.

  • 54.
    Brogårdh, Christina
    et al.
    Lund University Hospital.
    Lexell, Jan
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    A 1-year follow-up after shortened constraint-induced movement therapy with and without mitt poststroke2010Inngår i: Archives of Physical Medicine and Rehabilitation, ISSN 0003-9993, E-ISSN 1532-821X, Vol. 91, nr 3, s. 460-464Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    ObjectiveTo explore the long-term benefits of shortened constraint-induced movement therapy (CIMT) in the subacute phase poststroke.DesignA 1-year follow-up after shortened CIMT (3h training/d for 2wk) where the participants had been randomized to a mitt group or a nonmitt group.SettingA university hospital rehabilitation department.ParticipantsPoststroke patients (N=20, 15 men, 5 women; mean age 58.8y; on average 14.8mo poststroke) with mild to moderate impairments of hand function.InterventionsNot applicable.Main Outcome MeasuresThe Sollerman hand function test, the modified Motor Assessment Scale, and the Motor Activity Log test. Assessments were made by blinded observers.ResultsOne year after shortened CIMT, participants within both the mitt group and the nonmitt group showed statistically significant improvements in arm and hand motor performance and on self-reported motor ability compared with before and after treatment. No significant differences between the groups were found in any measure at any time.ConclusionsShortened CIMT seems to be beneficial up to 1 year after training, but the restraint may not enhance upper motor function. To determine which components of CIMT are most effective, larger randomized studies are needed.

  • 55.
    Burman, Erik
    et al.
    Department of Surgical and Perioperative Sciences, Umeå University.
    Lysholm, Jack
    Linköping University Hospital, Department of Orthopaedic Surgery, Sports and Ttrauma Research Group, Winternet, Bodens sjukhus, Ortopedkliniken, Läkarhuset Hermelinen Luleå, Sjukgymnastiken, Department of Orthopaedics, Surgical and Perioperative Sciences, Umeå University, Department of Orthopaedics, Sunderby Hospital.
    Shahim, Pashtun
    Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Department of Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal.
    Malm, Christer
    Umeå University, Department of Integrative Medical Biology, Winternet, Department of Sports Medicine, Department of Community Medicine and Rehabilitation, Umeå University.
    Tegner, Yelverton
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Concussed athletes are more prone to injury both before and after their index concussion: data base analysis of 699 concussed contact sports athletes2016Inngår i: BMJ Open Sport & Exercise Medicine, ISSN 2055-7647, Vol. 2, nr 1, artikkel-id e000092Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background Ice hockey and football players suffering concussions might have an increased risk for injuries afterwards. We aimed to investigate if concussions predisposed athletes for subsequent sport injuries. Methods Patient data were obtained from a data base established at the University Hospital in Umea, Sweden. Athletes who had suffered a concussion were included if they had been aged between 15 and 35 years of age, and played ice hockey, football (soccer), floorball and handball. They were studied in terms of all new or previous injuries during 24 months before and after their concussion. Results were compared with a control group of athletes from the same four sports with an ankle injury. Results Athletes with a concussion were more likely to sustain injuries compared with the control group, both before (OR 1.98. 95% CI 1.45 to 2.72) and after the concussion (OR 1.72. 95% CI 1.26 to 2.37). No increase in frequency of injury was found after a concussion compared with before. This was true for athletes in all four sports and for both sexes. Conclusions This study indicates that athletes sustaining a concussion may have a more aggressive or risk-taking style of play than their counterparts. Our data do not suggest that a concussion injury, per se, leads to subsequent injuries.

  • 56.
    Calner, Tommy
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Hälsa och rehabilitering.
    Isaksson, Gunilla
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Hälsa och rehabilitering.
    Michaelson, Peter
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Hälsa och rehabilitering. Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Physiotherapy treatment experiences of persons with persistent musculoskeletal pain: A qualitative study2019Inngår i: Physiotherapy Theory and Practice, ISSN 0959-3985, E-ISSN 1532-5040Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The aim of this study was to explore and describe the physiotherapy treatment experiences of persons with persistent musculoskeletal pain. Eleven participants with persistent musculoskeletal pain in the back, neck, or shoulders were included in the study. Data was collected via semi-structured interviews and were analysed with qualitative content analysis. The analysis resulted in the theme "Towards acceptance and management of pain", comprising four sub-themes: 1) Establishing and maintaining a therapeutic alliance; 2) Being active, taking initiative and facing challenges; 3) Appreciating guidance, incentive and having a sounding board; and 4) Acquired knowledge and new body awareness change behaviours. The theme and sub-themes describe how the participants used increased knowledge, awareness, movements and exercises learned from the physiotherapy treatment to develop strategies for managing pain and the process of acceptance. A trusting relationship and continual dialogue with the physiotherapist was considered to be important. The participants were actively involved in the process as exercises, activities and other treatment modalities were individualized. This was rewarding but also challenging and required effort on their part. The physiotherapist's initiatives and actions were an important incentive and means of support.

  • 57.
    Carson, JD
    et al.
    University of Toronto, Women's College Hospital Sport Centre for Advanced Research and Education.
    Tator, CH
    Toronto Western Hospital, Division of Neurosurgery.
    Provvidenza, CF
    ThinkFirst-SportSmart Sports and Recreational Injuries Research and Prevention Centre, Toronto.
    Tegner, Yelverton
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    LaPrade, RF
    University of Minnesota, Department of Orthopaedic Surgery.
    Biasca, Nicola
    Spital Oberengadin, Orthopaedic Clinic.
    Mueller, FO
    University of North Carolina at Chapel Hill.
    Mölsä, Jouko
    LIKES Research Center for Sport and Health Sciences, Jyväskylä.
    Cushman, RA
    Prevention of spinal injuries in ice hockey players: an international perspective2004Inngår i: Rendez-Vous 2004: Sport medicine symposium, Vancouver, Canada, March 15-17 2004, 2004, s. 380-Konferansepaper (Annet vitenskapelig)
  • 58.
    Catalan-Figueroa, Johanna
    et al.
    Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. Department of Biochemistry, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. Centro de Nanotecnología Aplicada, Universidad Mayor, Santiago, Chile.
    Boisset, Constanza B
    Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile.
    Jara, Miguel O
    Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile.
    Flores, Mario E
    Instituto de Ciencias Químicas, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.
    Moreno-Villoslada, Ignacio
    Instituto de Ciencias Químicas, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.
    Fiedler, Jenny L
    Centro de Nanotecnología Aplicada, Universidad Mayor, Santiago, Chile.
    Morales, Javier O.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap. Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile.
    A mechanistic approach for the optimization of loperamide loaded nanocarriers characterization: Diafiltration and mathematical modeling advantages2018Inngår i: European Journal of Pharmaceutical Sciences, ISSN 0928-0987, E-ISSN 1879-0720, Vol. 125, s. 215-222Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Oral bioavailability of loperamide is restricted by its limited absorption in the gastrointestinal tract due to its poor aqueous solubility and its P-glycoprotein (Pgp) substrate characteristic. In addition, ammonium methacrylate copolymers have shown to have mucoadhesive properties, whereas poloxamer 188, has been suggested as a Pgp inhibitor. Thus, in this work, we evaluate conditions that affect physicochemical parameters of ammonium methacrylate/poloxamer 188-based nanocarriers loaded with loperamide hydrochloride. Nanocarriers were synthesized by nanoprecipitation, enhancing loperamide encapsulation efficiency by modifying the aqueous phase to basic pH. The isolation of the non-encapsulated drug fraction from the nanocarriers-incorporated fraction was conducted by centrifugation, ultrafiltration, vacuum filtration and diafiltration. The last method was effective in providing a deeper understanding of drug-nanocarrier loading and interactions by means of modeling the data obtained by it. Through diafiltration, it was determined an encapsulation efficiency of about 93%, from which a 38% ±6 was shown to be reversibly (thermodynamic interaction) and a 62% ±6 irreversibly (kinetic interaction) bound. Finally, release profiles were assessed through empirical and semi-empirical modeling, showing a biphasic release behavior (burst effect 11.34% and total release at 6 h = 33% ±1). Thus, encapsulation efficiency and release profile were shown to have a strong mathematical modeling-based correlation, providing the mechanistic approach presented in this article a solid support for future translational investigations.

  • 59.
    Chattoraj, Sayantan
    et al.
    Pharmaceutical Materials Science & Engineering Laboratory, Department of Pharmaceutics, University of Minnesota.
    Shi, Limin
    Pharmaceutical Materials Science & Engineering Laboratory, Department of Pharmaceutics, University of Minnesota.
    Chen, Miles
    Pharmaceutical Materials Science & Engineering Laboratory, Department of Pharmaceutics, University of Minnesota.
    Alhalaweh, Amjad
    Velaga, Sitaram
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Sun, Changquan Calvin
    Pharmaceutical Materials Science & Engineering Laboratory, Department of Pharmaceutics, University of Minnesota.
    Origin of Deteriorated Crystal Plasticity and Compaction Properties of a 1:1 Cocrystal between Piroxicam and Saccharin2014Inngår i: Crystal Growth & Design, ISSN 1528-7483, E-ISSN 1528-7505, Vol. 14, nr 8, s. 3864-3874Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The 1:1 cocrystal between piroxicam and saccharin exhibits significantly deteriorated powder compaction properties compared to both coformers. The molecular origin of this effect is revealed by a systematic investigation of crystal mechanical properties, probed with nanoindentation, and crystal structure analysis. The order of bulk powder tabletability of the three materials is identical to that of single crystal plasticity (saccharin > piroxicam > cocrystal). The lowest plasticity of the cocrystal is confirmed by its highest crystal hardness and the highest yield strength. The low plasticity of the cocrystal is attributed to structural packing features that discourage plastic deformation. This work demonstrates that cocrystallization, even though it may be useful to improve pharmaceutically relevant properties, must be carefully evaluated to avoid unexpected problems in formulation and drug product manufacturing due to compromised mechanical properties.

  • 60.
    Cho, Wonkyung
    et al.
    College of Pharmacy, Yonsei University.
    Kim, Min-Soo
    College of Pharmacy, Pusan National University.
    Jung, Min-Sook
    College of Pharmacy, Chungnam National University.
    Park, Junsung
    College of Pharmacy, Yonsei University.
    Cha, Kwang-Ho
    College of Pharmacy, Yonsei University.
    Kim, Jeong-Soo
    College of Pharmacy, Chungnam National University.
    Alhalaweh, Amjad
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Velaga, Sitaram
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Park, Hee Jun
    College of Pharmacy, Chungnam National University.
    Hwang, Sung-Joo
    College of Pharmacy, Chungnam National University.
    Design of salmon calcitonin particles for nasal delivery using spray-drying and novel supercritical fluid-assisted spray-drying processes2015Inngår i: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 478, nr 1, s. 288-296Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The overall aim of this study was to prepare a nasal powder formulation of salmon calcitonin (sCT) using an absorption enhancer to improve its bioavailability. In this work, powder formulations for nasal delivery of sCT were studied using various absorption enhancers and stabilizers. Powders were prepared by two different methods: conventional spray-drying (SD) and novel supercritical fluid-assisted spray-drying (SASD) to investigate the role of CO2 in the particle formation process. The prepared sCT powder formulations were characterized by several analyses; powder X-ray diffractometry (PXRD), scanning electron microscopy (SEM), and the Fourier transform infrared (FT-IR) spectroscopy method. The particle size distribution was also evaluated. In vivo absorption tests were carried out in Sprague-Dawley rat using the prepared powder formulations, and the results were compared to those of raw sCT. Quantitative analysis by high-performance liquid chromatography (HPLC) indicated that sCT was chemically stable after both the SD and SASD processes. Results of PXRD, SEM, and FT-IR did not indicate a strong interaction or defragmentation of sCT. The in vivo absorption test showed that SD- and SASD-processed sCT powders increased the bioavailability of the drug when compared to the nasal administration of raw sCT. In addition, SASD-processed sCT exhibited higher nasal absorption when compared with SD-processed sCT in all formulations due to a reduction of particle size. The results from this study illustrate that the preparation of nasal powders using the SASD process could be a promising approach to improve nasal absorption of sCT.

  • 61.
    Dalpiaz, Alessandro
    et al.
    University of Ferrara.
    Marchetti, Nicola
    University of Ferrara.
    Cavazzini, Alberto
    University of Ferrara.
    Pasti, Luisa
    University of Ferrara.
    Velaga, Sitaram
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Gavini, Elisabetta
    University of Sassari.
    Beggiato, Ssrah
    University of Ferrara.
    Ferraro, Luca
    University of Ferrara, Department of Clinical and Experimental Medicine, Pharmacol Sect.
    Quantitative determination of zolmitriptan in rat blood and cerebrospinal fluid by reversed phase HPLC-ESI-MS/MS analysis: application to in vivo preclinical pharmacokinetic study2012Inngår i: Journal of chromatography. B, ISSN 1570-0232, E-ISSN 1873-376X, Vol. 901, s. 72-78Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A fast HPLC-ESI-MS/MS method has been developed and validated for the quantification of the potent and selective antimigraine zolmitriptan in rat blood and cerebrospinal fluid (CSF). The assay has been then applied for in vivo preclinical studies. The analytical determination has been used to obtain pharmacokinetics of zolmitriptan in the two biological matrices after its intravenous or nasal administration. Liquid-liquid extraction of zolmitriptan was performed from 100μL rat blood samples in the presence of N 6-cyclopentyladenosine (internal standard) with the employment of ethyl acetate. Calibration standards were prepared by using blood matrix and following the same liquid-liquid extraction procedure. CSF samples were analyzed without any pre-treatment steps and by using an external calibration method in pure water matrix. Chromatographic separation was performed under reversed phase and a gradient elution condition on a C18 packed column (100×2.0mm, 2.5μm particles diameter). The mobile phase was a mixture between acetonitrile, water and formic acid (0.1% v/v). The applied HPLC-MS/MS method allowed low limits of detection, as calculated from calibration curves, of 6.6 and 24.4ng/mL for water matrix and rat blood extracts, respectively. Linearity of the calibration curves was established up to 5μM (1.44μg/mL), as well as good assay accuracy. The intravenous infusion of 20μg zolmitriptan to male Sprague-Dawley rats produced blood concentrations ranging from 9.4±0.7 to 1.24±0.07μg/mL within 10h, with a terminal half-life of 3.4±0.2h. The nasal administration of a water suspension of 20μg zolmitriptan produced blood concentrations ranging from 2.92±0.21 to 0.85±0.07μg/mL within 6h. One hour after zolmitriptan intravenous infusion or nasal administration, its CSF concentrations were 0.0539±0.0016 and 0.0453±0.0012μg/mL, respectively. This study determined the suitability of the herein proposed method to investigate the pharmacokinetics of zolmitriptan after its administration by means of novel formulations and, hence, to evaluate the efficacy of innovative nose-to-brain drug delivery in preclinical studies.

  • 62.
    Degermark, Gunilla
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Blodtrycksmätning2011Annet (Annet (populærvitenskap, debatt, mm))
  • 63.
    Degermark, Gunilla
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Handdesinfektion2011Annet (Annet (populærvitenskap, debatt, mm))
  • 64.
    Degermark, Gunilla
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Hygienisk handtvätt2011Annet (Annet (populærvitenskap, debatt, mm))
  • 65.
    Degermark, Gunilla
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Intramuskulär injektion2011Annet (Annet (populærvitenskap, debatt, mm))
  • 66.
    Degermark, Gunilla
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Pulspalpation2011Annet (Annet (populærvitenskap, debatt, mm))
  • 67.
    Degermark, Gunilla
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Påtagning av sterlia handskar2011Annet (Annet (populærvitenskap, debatt, mm))
  • 68.
    Degermark, Gunilla
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Sondnedläggning2011Annet (Annet (populærvitenskap, debatt, mm))
  • 69.
    Degermark, Gunilla
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Steril uppdukning2011Annet (Annet (populærvitenskap, debatt, mm))
  • 70.
    Degermark, Gunilla
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Subcutan injektion2011Annet (Annet (populærvitenskap, debatt, mm))
  • 71.
    Degermark, Gunilla
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Subcutan injektion (förfylld spruta)2011Annet (Annet (populærvitenskap, debatt, mm))
  • 72.
    Degermark, Gunilla
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Såromläggning (Ren rutin)2011Annet (Annet (populærvitenskap, debatt, mm))
  • 73.
    Dietrich, Marcelo O.
    et al.
    Universidade Federal do Rio Grande do Sul, Departamento de Bioquimica, ICBS.
    Souza, DO
    Universidade Federal do Rio Grande do Sul, Departamento de Bioquimica, ICBS.
    Portela, LV
    Universidade Federal do Rio Grande do Sul, Departamento de Bioquimica, ICBS.
    Stålnacke, Britt-Marie
    Umeå University, Department of Community Medicine and Rehabilitation, Rehabilitation Medicine.
    Tegner, Yelverton
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Sojka, Peter
    Department of Community Medicine and Rehabilitation, Rehabilitation Medicine, Umeå univesity.
    Serum S100B protein: what does it mean during exercise?2004Inngår i: Clinical Journal of Sports Medicine, ISSN 1050-642X, E-ISSN 1536-3724, Vol. 14, nr 6, s. 368-9Artikkel i tidsskrift (Fagfellevurdert)
  • 74.
    Downham, David Y.
    et al.
    University of Liverpool.
    Holmbäck, Anna Maria
    Lund University.
    Lexell, Jan
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Reliability of measurements in medical research and clinical practice2005Inngår i: Multidisciplinary Approaches to Theory in Medicine, Amsterdam: Elsevier, 2005, s. 147-163Kapittel i bok, del av antologi (Annet vitenskapelig)
  • 75.
    Dudenko, D.V.
    et al.
    Cardiff University.
    Williams, P.A.
    Cardiff University.
    Hughes, C.E.
    Cardiff University.
    Antzutkin, Oleg
    Luleå tekniska universitet, Institutionen för samhällsbyggnad och naturresurser, Industriell miljö- och processteknik.
    Velaga, Sitaram
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Brown, S.P.
    University of Warwick.
    Harris, K.D.M.
    Cardiff University.
    Exploiting the synergy of powder x-ray diffraction and solid-state NMR spectroscopy in structure determination of organic molecular solids2013Inngår i: The Journal of Physical Chemistry C, ISSN 1932-7447, E-ISSN 1932-7455, Vol. 117, nr 23, s. 12258-12265Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We report a strategy for structure determination of organic materials in which complete solid-state nuclear magnetic resonance (NMR) spectral data is utilized within the context of structure determination from powder X-ray diffraction (XRD) data. Following determination of the crystal structure from powder XRD data, first-principles density functional theory-based techniques within the GIPAW approach are exploited to calculate the solid-state NMR data for the structure, followed by careful scrutiny of the agreement with experimental solid-state NMR data. The successful application of this approach is demonstrated by structure determination of the 1:1 cocrystal of indomethacin and nicotinamide. The 1H and 13C chemical shifts calculated for the crystal structure determined from the powder XRD data are in excellent agreement with those measured experimentally, notably including the two-dimensional correlation of 1H and 13C chemical shifts for directly bonded 13C-1H moieties. The key feature of this combined approach is that the quality of the structure determined is assessed both against experimental powder XRD data and against experimental solid-state NMR data, thus providing a very robust validation of the veracity of the structure

  • 76.
    Elbadawi, Mohammed
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap. Luleå tekniska universitet, Institutionen för system- och rymdteknik, Signaler och system.
    Andrikopoulos, Georgios
    Luleå tekniska universitet, Institutionen för system- och rymdteknik, Signaler och system.
    Nikolakopoulos, George
    Luleå tekniska universitet, Institutionen för system- och rymdteknik, Signaler och system.
    Gustafsson, Thomas
    Luleå tekniska universitet, Institutionen för system- och rymdteknik, Signaler och system.
    Bio-Inspired Climbing Robots in Wet Environments: Recent Trends in Adhesion Methods and Materials2018Konferansepaper (Fagfellevurdert)
  • 77.
    Elbadawi, Mohammed
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Meredith, James
    Mosalagae, Mosalagae
    Reaney, Ian M
    Porous hydroxyapatite scaffolds fabricated from nano-sized powder via honeycomb extrusion2017Inngår i: Advanced Materials Letters, ISSN 0976-3961, E-ISSN 0976-397X, Vol. 8, nr 4, s. 377-385Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    In this study, we have developed hydroxyapatite (HA) scaffolds for synthetic bone graft from nano-sized HA particles using ceramic extrusion. We also demonstrate that these HA scaffolds show enhanced compressive strength (29.4 MPa), whilst possessing large pore sizes (> 600 µm) that are suitable for bone grafting. The extrusion process involved forming a ceramic paste by mixing the HA powder with a binder and distilled water. The ceramic paste was then fabricated using a ram extruder that was fitted with a honeycomb die to impart large, structured pores. Several green bodies were extruded and then subjected to the same drying and thermal debinding treatment. The samples underwent three different sintering temperatures and two varied dwell times, in order to determine the optimum sintering parameters. The scaffolds were then analysed for their chemical, physical, mechanical and biological properties to elucidate the effects of the sintering parameters on extruded HA scaffolds. The results revealed that the nano-sized particles exhibited a high sinterability, and XRD analysis showed phase purity until 1300 oC. At 1300 oC, trace amounts of phase impurities were detected, however, scaffolds sintered at this temperature exhibited the highest mean compressive strength. The findings demonstrated that traces of phase impurities were not detrimental to the scaffold’s compressive strength. In addition, scanning electron microscopy and density measurements revealed a highly densified solid phase was attained.

  • 78.
    Elbadawi, Mohammed
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Mosalagae, Mosalagae
    Goodall, Russell
    Tape casting and lost carbonate sintering processes for production of heat sinks for portable electronics2017Inngår i: Advanced Materials Letters, ISSN 0976-3961, E-ISSN 0976-397X, Vol. 8, nr 7, s. 807-812Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Porous copper was fabricated by means of a powder metallurgy process applied to tape casting. Lost Carbonate Sintering (LCS) was employed to control porosity within the component during processing. The weight ratio of the potassium carbonate introduced into the matrix ranged from 30-40 wt%. Additives such as; plasticizers, binders, dispersant and solvents were utilized to control the properties throughout the processes and ease fabrication. The component was debinded and sintered at 400 °C and 900 °C respectively, under vacuum. The potassium carbonate was removed from the sintered component via dissolution in water. By using X-ray Florescence (XRF) and Energy Dispersive X-ray Spectrometry (EDS) techniques, the effectiveness of the dissolution route at removing the space holder was investigated. The results shows that porous copper produced in this way has porosity ranging from 75-85 % and pore size from 500-766 mm. The component produced has thickness ranging from 1300 -1800 mm.

  • 79.
    Elbadawi, Mohammed
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap. Department of Mechanical Engineering, University of Sheffield, Sheffield, United Kingdom.
    Wally, Zena J.
    Department of Materials Science and Engineering, University of Sheffield, Sheffield, UK.
    Reaney, Ian
    Department of Materials Science and Engineering, University of Sheffield, Sheffield, UK.
    Porous Hydroxyapatite-Bioactive Glass Hybrid Scaffolds Fabricated via Ceramic Honeycomb Extrusion2018Inngår i: Journal of The American Ceramic Society, ISSN 0002-7820, E-ISSN 1551-2916, Vol. 101, nr 8, s. 3541-3556Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The successful fabrication of hydroxyapatite-bioactive glass scaffolds using honeycomb extrusion is presented herein. Hydroxyapatite was combined with either 10 wt% stoichiometric Bioglass® (BG1), calcium-excess Bioglass® (BG2) or canasite (CAN). For all composite materials, glass-induced partial phase transformation of the HA into the mechanically weaker β-tricalcium phosphate (TCP) occurred but XRD data demonstrated that BG2 exhibited a lower volume fraction of TCP than BG1. Consequently, the maximum compressive strength observed for BG1 and BG2 were 30.3 ± 3.9 and 56.7 ± 6.9 MPa, respectively, for specimens sintered at 1300 °C. CAN scaffolds, in contrast, collapsed when handled when sintered below 1300 °C, and thus failed. The microstructure illustrated a morphology similar to that of BG1 sintered at 1200 °C, and hence a comparable compressive strength (11.4 ± 3.1 MPa). The results highlight the great potential offered by honeycomb extrusion for fabricating high-strength porous scaffolds. The compressive strengths exceed that of commercial scaffolds, and biological tests revealed an increase in cell viability over seven days for all hybrid scaffolds. Thus it is expected that the incorporation of 10 wt% bioactive glass will provide the added advantage of enhanced bioactivity in concert with improved mechanical stability.

  • 80.
    Engström, Åsa
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Omvårdnad.
    Johansson, Maria
    Intensive Care Unit, Gällivare Hospital.
    Mattsson, Mia
    Intensive Care Unit 57, Sunderby Hospital.
    Strömbäck, Ulrica
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Nursing Care of ICU Patients Lightly Sedated with Dexmedetomidine2016Inngår i: Journal of Clinical Intensive Care and Medicine, ISSN 2639-6653, Vol. 1, s. 5-13Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Intensive care patients are often in need of sedation to endure being intubated. Lightsedation is increasingly common since it has been proved to offer benefi ts such as faster recovery to patients.Aim: The aim of this study was to describe critical care nurses’ experiences of nursing patients lightlysedated with dexmedetomidine.Research Methodology: Qualitative personal interviews were conducted during 2015 with 10 critical carenurses in Sweden. Interview transcripts were analysed using inductive qualitative thematic analysis.Results: Light sedation of the patient facilitated communication and interaction with him or her, and therelationship between the patient and his or her family members. Dexmedetomidine was described as a fairlynew drug, and the critical care nurses stated that they needed more knowledge about it and about sedationscales in order to learn more about the drug’s mechanism of action and its potential side effects on patients.Conclusion: It is important to critical care nurses to learn more about dexmedetomidine and about sedationscales to assess levels of sedation, as light sedation has been shown to benefi t the patient as opposed to deepsedation that can increase recovery time.

  • 81.
    Eriksson, Anders
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Styrketräning inom elitidrott2001Inngår i: Svensk Idrottsforskning: Organ för Centrum för Idrottsforskning, ISSN 1103-4629, Vol. 10, nr 3, s. 30-3Artikkel i tidsskrift (Annet vitenskapelig)
  • 82.
    Eriksson, Anders
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Kadi, Fawzi
    Örebro University, Department of Physical Education and Health.
    Malm, Christer
    Umeå University, Department of Integrative Medical Biology.
    Thornell, Lars-Eric
    Umeå University, Department of Integrative Medical Biology.
    Skeletal muscle morphology in power-lifters with and without anabolic stereoids2005Inngår i: Histochemistry and Cell Biology, ISSN 0948-6143, E-ISSN 1432-119X, Vol. 124, nr 2, s. 167-75Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The morphological appearance of the vastus lateralis (VL) muscle from high-level power-lifters on long-term anabolic steroid supplementation (PAS) and power-lifters never taking anabolic steroids (P) was compared. The effects of long- and short-term supplementation were compared. Enzyme-immunohistochemical investigations were performed to assess muscle fiber type composition, fiber area, number of myonuclei per fiber, internal myonuclei, myonuclear domains and proportion of satellite cells. The PAS group had larger type I, IIA, IIAB and IIC fiber areas (p<0.05). The number of myonuclei/fiber and the proportion of central nuclei were significantly higher in the PAS group (p<0.05). Similar results were seen in the trapezius muscle (T) but additionally, in T the proportion of fibers expressing developmental myosin isoforms was higher in the PAS group compared to the P group. Further, in VL, the PAS group had significantly larger nuclear domains in fibers containing > or = 5 myonuclei. The results of AS on VL morphology in this study were similar to previously reported short-term effects of AS on VL. The initial effects from AS appear to be maintained for several years.

  • 83.
    Eriksson, Anders
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Lindström, Mona
    Umeå University, Department of Integrative Medical Biology.
    Carlsson, Lena
    Umeå University, Department of Integrative Medical Biology.
    Thornell, Lars-Eric
    Umeå University, Department of Integrative Medical Biology.
    Hypertrophic muscle fibers with fissures in power-lifters: fiber splitting or defect regeneration?2006Inngår i: Histochemistry and Cell Biology, ISSN 0948-6143, E-ISSN 1432-119X, Vol. 126, nr 4, s. 409-17Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Power-lifters have hypertrophic muscle fibers with fissures seen in cross-sections, called as fiber splitting.Whether this phenomenon is due to real splitting or defective regeneration has not been settled. To elucidate this matter,we have examined biopsies from the trapezius and vastus lateralis of power lifters (P group) and power lifters self-administrating anabolic steroids (PAS group). For this purpose, immunohistochemical staining of serial cross -sections was used. The PAS group had significantly more fibers with fissures than the P group in the vastus lateralis (1.2%+/- 0.95% vs 0.35+/-0.34, P < 0.05) but not in the trapezius muscle (1.7% in both groups). Serial sections revealed that the fibers with fissures changed their profile profoundly over short distances. Some such fibers had a mature staining profile, whereas other fibers indicated recent degeneration and/or regeneration. Activation of satellite cells and formation of aberrant segments were also evident. We conclude that the so-called split fibers are due to defect regeneration. Some fibers with fissures are the results of old events of segmental muscle fiber damage, whereas the others reflect an ongoing process. The normal regenerative process is most likely disturbed in power-lifters by their continuous training with repeated high mechanical stress on the muscles.

  • 84.
    Eriksson, Thomas
    et al.
    Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö.
    Isaksson, Marléne
    Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö.
    Tegner, Yelverton
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    The use of photos from patch-test reactions on day 7 taken by mobile phones by professional ice hockey players in Sweden investigated for the presence of occupational dermatoses2016Konferansepaper (Fagfellevurdert)
  • 85.
    Eriksson, Thomas
    et al.
    Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö.
    Isaksson, Marléne
    Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö.
    Tegner, Yelverton
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Bruze, M.
    Department of Occupational and Environmental Dermatology, Skåne University Hospital.
    The use of photos from patch-test reactions on day 7 taken by mobile phones by professional ice hockey players in Sweden investigated for the presence of occupational dermatoses2016Inngår i: Contact Dermatitis, ISSN 0105-1873, E-ISSN 1600-0536, Vol. 75, nr Suppl. 1, s. 39-Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    survey was undertaken in all ice hockey players in 26 professional teams in Sweden representing the two highest divisions. All players answered a questionnaire and the players from six teams, three from each of the two divisions, were patch tested with 72 test preparations in a baseline series supplemented with a series representing the work environment of the players. For practical reasons, the patch testing and test reading on day 3 took place in the arenas of the teams. As a traditional dermatologist reading on day 7 was impossible to perform in all but one team, the players and coaches were asked to use their mobile phones to take photos of the tested backs of the players on day 7 and to send them to the investigative team. In one team a dermatologist reading took place on day 7 independently of the mobile phone photos. In total, 107 players in the six teams were patch tested, and a reading on day 3 was performed in 103. Fifty contact allergic reactions were noted in 26 players. When comparing the reactions present on day 3 with the photos from day 7, seven (14%) more positive reactions were registered. The seven additional reactions were noted to seven different sensitizers: hexavalent chromium, oxidized linalool, thiomersal, mercapto mix, mercaptobenzothiazole, PFR-2 (a resol resin based on phenol and formaldehyde) and methylenedianiline. In summary, 14% more contact allergic reactions were diagnosed when using photos of the tested backs to replace the traditional dermatologist reading.

  • 86.
    Eriksson, Tomas
    et al.
    Occupational and Environmental Dermatology.
    Isaksson, Marlene
    Occupational and Environmental Dermatology.
    Engfeldt, Malin
    Occupational and Environmental Dermatology, University of Malmo-Lund.
    Tegner, Yelverton
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Bruze, Magnus
    Occupational and Environmental Dermatology.
    conact allergy in ice hockey players in Sweden2010Konferansepaper (Annet vitenskapelig)
  • 87.
    Ersson, Bernt
    et al.
    Allmänläkare, Gävle.
    Aurell, Inger
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Billsen, Mats
    Ortopediska kliniken Hässleolm-Kristianstad.
    Dobrescu, Tudor
    Tudorkliniken, Halmstad.
    Dobrescu, Daniela
    Landstingshälsan, Halmstad.
    Flodin, Marianne
    Värmdö Primärvård.
    Pettersson-Hanning, Jan
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Henriksson, Anders
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Holmberg, Göran
    Jensen, Jörn
    Sjukhuset Varberg, Röntgenkliniken.
    Ludwig, Bernd
    Landskrona Läkargrupp.
    Magnusson, Ulla
    Möller, Agneta
    Läkarhuset Hermelinen Luleå, Sjukgymnastiken.
    Tegner, Yelverton
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Osteoporos: DXL-hälmätare använd med förstånd räcker långt för klinisk användning2003Inngår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 100, nr 3, s. 156-157Artikkel i tidsskrift (Annet vitenskapelig)
  • 88.
    Eshuis, Rienk
    et al.
    St. Antonius Hospital, Department of Orthopedic Surgery, Nieuwegein.
    Lentjes, Gijsbertus Wilhelmus
    St. Antonius Hospital, Department of Orthopedic Surgery, Nieuwegein.
    Tegner, Yelverton
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Wolterbeek, Nienke
    St. Antonius Hospital, Department of Orthopedic Surgery, Nieuwegein.
    Veen, Maurits Remmelt
    St. Antonius Hospital, Department of Orthopedic Surgery, Nieuwegein.
    Dutch Translation and Cross-cultural Adaption of the Lysholm Score and Tegner Activity Scale for Patients With Anterior Cruciate Ligament Injuries2016Inngår i: Journal of Orthopaedic and Sports Physical Therapy, ISSN 0190-6011, E-ISSN 1938-1344, Vol. 46, nr 11, s. 976-983Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Study Design Clinical measurement. Background The Lysholm score and Tegner Activity Scale are frequently used patient-reported instruments to determine the functional status and activity level after anterior cruciate ligament (ACL) reconstruction. Objectives To translate and cross-culturally adapt the Lysholm score and Tegner Activity Scale for use in the Dutch population and to evaluate reliability and validity of these questionnaires in individuals after ACL reconstruction. Methods The translation and adaptation was conducted in several steps according to the guidelines in the literature. The measurement properties of the Lysholm score and Tegner Activity Scale (internal consistency, construct validity, and floor and ceiling effects) were tested in 96 patients. Reproducibility was tested in 69 patients, for patient with anterior cruciate ligament injuries. On the first occasion, the International Knee Documentation Committee (IKDC) and RAND-36 item Health Survey (RAND-36) were also administered. Results The Lysholm score and Tegner Activity Scale showed good test-retest reliability between repeated measures (respectively ICC 0.93 and 0.97). Internal consistency was reasonable to good (Cronbach's α=0.70-0.83). The Lysholm score had a very strong correlation with the IKDC (r= 0.83, p<0.01) and moderate correlation with the RAND-36 (r=0.55, p<0.01). The Tegner Activity Scale had a moderate correlation with both IKDC and the RAND-36 (r= 0.42 p<0.01 respectively r= 0.48 p<0.01). Conclusion This study demonstrated acceptable psychometric performances for the Lysholm score and the Tegner scale as outcome measures for Dutch patients after ACL reconstruction. J Orthop Sports Phys Ther, Epub 28 Sep 2016. doi:10.2519/jospt.2016.6566.

  • 89.
    Flansbjer, Ulla-Britt
    et al.
    Department of Rehabilitation Medicine, Skåne University Hospital.
    Lexell, Jan
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Reliability of knee extensor and flexor muscle strength measurements in persons with late effects of polio2010Inngår i: Journal of Rehabilitation Medicine, ISSN 1650-1977, E-ISSN 1651-2081, Vol. 42, nr 6, s. 588-592Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective: To assess the reliability of knee extensor and flexor muscle strength measurements in persons with late effects of polio. Design: A test-retest reliability study. Subjects: Thirty men and women (mean age 63 (standard deviation 6.4) years) with verified late effects of polio. Methods: Knee extensor and flexor muscle strength in both lower limbs were measured twice 7 days apart using a Biodex dynamometer (isokinetic concentric contractions at 60°/sec and isometric contractions with knee flexion angle 90º) and a Leg Extension/Curl Rehab exercise machine with pneumatic resistance (HUR) (isotonic contractions). Reliability was assessed with the intraclass correlation coefficient (ICC1,1), the mean difference between the test sessions (đ) together with the 95% confidence intervals for đ, the standard error of measurement (SEM and SEM%), the smallest real difference (SRD and SRD%) and Bland-Altman graphs. Results: Test-retest agreements were high, (ICC1,1 0.93-0.99) and measurement errors generally small. The SEM% was 4-14% and the SRD% 11-39%, with the highest values for the isokinetic measurements. Conclusion: Knee muscle strength can be measured reliably and can be used to detect real changes after an intervention for a group of persons with late effects of polio, whereas the values may be too high for single individuals or to detect smaller short-term changes over time for a group of individuals.

  • 90.
    Fritz, Hans F.
    et al.
    Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile.
    Ortiz, Andrea C.
    Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile.
    Velaga, Sitaram
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Morales, Javier O.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap. Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile.
    Preparation of a novel lipid-core micelle using a low-energy emulsification method2018Inngår i: Drug Delivery and Translational Research, ISSN 2190-393X, Vol. 8, nr 6, s. 1807-1814Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    High-energy methods for the manufacturing of nanomedicines are widely used; however, interest in low-energy methods is increasing due to their simplicity, better control over the process, and energy-saving characteristics during upscaling. Here, we developed a novel lipid-core micelle (LCM) as a nanocarrier to encapsulate a poorly water-soluble drug, nifedipine (NFD), by hot-melt emulsification, a low-energy method. LCMs are self-assembling colloidal particles composed of a hydrophobic core and a hydrophilic shell. Hybrid materials, such as Gelucire 44/14, are thus excellent candidates for their preparation. We characterized the obtained nanocarriers for their colloidal properties, drug loading and encapsulation efficiency, liquid state, stability, and drug release. The low-energy method hot-melt emulsification was successfully adapted for the manufacturing of small and narrowly dispersed LCMs. The obtained LCMs had a small average size of ~ 11 nm and a narrow polydispersity index (PDI) of 0.228. These nanocarriers were able to increase the amount of NFD dispersible in water more than 700-fold. Due to their sustained drug release profile and the PEGylation of Gelucire 44/14, these nanocarriers represent an excellent starting point for the development of drug delivery systems designed for long circulation times and passive targeting.

  • 91.
    Gardelli, Åsa
    et al.
    Luleå tekniska universitet, Institutionen för konst, kommunikation och lärande, Pedagogik, språk och Ämnesdidaktik.
    Backman, Ylva
    Luleå tekniska universitet, Institutionen för konst, kommunikation och lärande, Pedagogik, språk och Ämnesdidaktik.
    Gardelli, Teodor
    Luleå tekniska universitet, Institutionen för konst, kommunikation och lärande, Pedagogik, språk och Ämnesdidaktik.
    Gardelli, Viktor
    Luleå tekniska universitet, Institutionen för konst, kommunikation och lärande, Pedagogik, språk och Ämnesdidaktik.
    Jacobsson, Lars
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Hälsa och rehabilitering. Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Strömberg, Caroline
    Luleå tekniska universitet, Institutionen för ekonomi, teknik och samhälle, Samhällsvetenskap.
    Utbildning för delaktighet: att filosofera tillbaka ett "nytt" liv efter förvärvad hjärnskada2018Inngår i: Resultatdialog 2018, Stockholm: Vetenskapsrådet , 2018, s. 49-52Kapittel i bok, del av antologi (Annet vitenskapelig)
    Abstract [sv]

    Ett stort antal personer i Sverige drabbas varje år av förvärvade hjärnskador, ofta med livslånga konsekvenser som nedsatta kognitiva, kommunikativa och sociala förmågor, samt minskat välbefinnande. Detta kan leda till utanförskap, svårigheter med studier, långvarig arbetslöshet och stort lidande för den drabbade och anhöriga, liksom till stora samhälleliga kostnader. Filosofiska samtal har visat sig ha positiva effekter för barn. Vår studie visar att sådana samtal framgångsrikt kan användas också i utbildning för personer med förvärvade hjärnskador. Den antyder positiva effekter inom bland annat kognitiv, kommunikativ och social utveckling.

  • 92.
    Gavini, Elisabetta
    et al.
    Department of Chemistry and Pharmacy, University of Sassari.
    Rassu, Giovanna
    Department of Chemistry and Pharmacy, University of Sassari.
    Ferraro, Luca
    Department of Experimental and Clinical Medicine, Pharmacology Section, University of Ferrara.
    Beggiato, Sarah
    Department of Experimental and Clinical Medicine, Pharmacology Section, University of Ferrara.
    Alhalaweh, Amjad
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Velaga, Sitaram
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Marchetti, Nichola
    Department of Chemistry, University of Ferrara.
    Bandiera, Pasquale
    Department of Biomedical Sciences, University of Sassari.
    Giunchedi, Paolo
    Department of Chemistry and Pharmacy, University of Sassari.
    Dalpiaz, Alessandro
    Department of Pharmaceutical Sciences, University of Ferrara.
    Influence of polymeric microcarriers on the in-vivo intranasal uptake of an anti-migraine drug for brain targeting2013Inngår i: European journal of pharmaceutics and biopharmaceutics, ISSN 0939-6411, E-ISSN 1873-3441, Vol. 83, nr 2, s. 174-183Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The objective of this study was to investigate the effect of polymeric microcarriers on the in-vivo intranasal uptake of an anti-migraine drug for brain targeting. Mucoadhesive powder formulations consisted of antimigraine drug, zolmitriptan, and chitosans (various molecular weights and types) or hydroxypropyl methylcellulose (HPMC). Their suitability for nasal administration was evaluated by in-vitro and ex-vivo mucoadhesion and permeation tests. The formulations based on chitosan glutamate (CG) or HPMC were tested in-vivo because they showed good mucoadhesive properties and altered the permeation rate of the drug. The in-vivo results from intravenous infusion and nasal aqueous suspension of the drug or nasal particulate powders were compared. The plasmatic AUC values obtained within 8 h following intravenous administration appeared about three times higher than those obtained by nasal administration, independent of the formulations. Zolmitriptan concentrations in the cerebrospinal fluid obtained from nasal and intravenous administrations were respectively 30 and 90 times lower than the concentrations of the drug in the blood. Thus, nasal administration potentiated the central zolmitriptan activity allowing a reduction of the drug peripheral levels, with respect to the intravenous administration. Among nasally administered formulations, CG microparticles showed the highest efficacy in promoting the central uptake of zolmitriptan within 1 h.

  • 93.
    Gustavsson, Linda
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap. Department of Anaesthesia, Central Operation Ward, Sunderby Hospital.
    Nyström, Cecilia
    Intensive Care Unit 57, Sunderby Hospital.
    Vikman, Irene
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Hälsa och rehabilitering.
    Engström, Åsa
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Omvårdnad.
    Sore throat and pressure differences in ventilation in women after intubation with an endotrachealtube size 6,5 or 7,02013Konferansepaper (Annet vitenskapelig)
  • 94.
    Gustavsson, Linda
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap. Department of Anaesthesia, Central Operation Ward, Sunderby Hospital.
    Vikman, Irene
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Hälsa och rehabilitering.
    Nyström, Cecilia
    Intensive Care Unit 57, Sunderby Hospital.
    Engström, Åsa
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Omvårdnad.
    Sore throat in women after intubation with 6.5 or 7.0 mm endotracheal tube: a quantitative study2014Inngår i: Intensive & Critical Care Nursing, ISSN 0964-3397, E-ISSN 1532-4036, Vol. 30, nr 6, s. 318-324Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Women experience more sore throats than men after endotracheal intubation.Aim: The aim of this study was to investigate the incidence of self-rated sore throat immediately,and 2—4 hours postoperatively, in women after elective gynaecological surgery under generalanaesthesia using an endotracheal tube (ETT) size 6.5 or 7.0 mm in inner diameter.Method: Eighty-two female participants who had undergone elective gynaecological surgeryparticipated, 44 and 38 were intubated with size 6.5 mm ETT and 7.0 mm ETT respectively.They estimated the occurrence of sore throat preoperatively and postoperatively, according toa 4-point Likert scale. Statistical data were analysed using the Package for Social Science (SPSS)19.Results: Sore throat was present in 29.5% of participants who were intubated with size 6.5 mmETT immediately postoperatively and in 39.5% of those who were intubated with size 7.0 mmETT.Conclusion: Nurses specialising in the supervision of daily care specific to the intubated patientshould note and alleviate sore throat as part of their nursing care.

  • 95.
    Hallikainen, J.
    et al.
    Department of Emergency Medicine at Södersjukhuset and Clinical Science and Education at Södersjukhuset, Karolinska Institutet, Sweden. Department of Emergency Medicine and Services, Helsinki University Hospital and University of Helsinki, Finland.
    Castrén, M.
    Department of Emergency Medicine at Södersjukhuset and Clinical Science and Education at Södersjukhuset, Karolinska Institutet, Sweden. Department of Emergency Medicine and Services, Helsinki University Hospital and University of Helsinki, Finland.
    Niemi-Murola, L.
    Department of Anesthesiology and Intensive Care Medicine, University of Helsinki and Helsinki University Hospital, Finland.
    Ljungquist, Helena Nord
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Bohm, K.
    Department of Emergency Medicine at Södersjukhuset and Clinical Science and Education at Södersjukhuset, Karolinska Institutet, Sweden.
    The Wording of Telephone Guided CPRAffect on Senior Citizens Performance: A Simulation Study2018Inngår i: SM Journal of Clinical Medicine, ISSN 2573-3680, Vol. 4, nr 1, artikkel-id 1032Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives: To assess how senior citizens followed Telephone CPR (T-CPR) instructions in a simulated cardiac arrest scenario. Methods: Twenty-two voluntary senior citizens were studied in a simulated cardiac arrest scenario following the instructions given to them by an Emergency Medical Dispatcher. The phone calls and the CPR performance were recorded and analyzed. Results: The rescuers reported that they had performed better than the analysis of video and phone call recordings showed. When asked after the scenario the rescuers felt that they had coped with the situation well 72% and quite well 28% of the cases. Every participant evaluated the given telephone CPR instructions as very easy to understand. 35% of the participants thought that performing CPR was physically quite easy. The unexpected result was the EMDs’ bad protocol compliance. Protocol was not strictly followed by the dispatchers. They gave more straight forward instructions without the full knowledge of the situation, than they should have. From the 12 analyzed instructions that the dispatchers should have given to the rescuer, only three instructions (give two deep rescue breaths, correct positioning of the rescuers arms and to compress 15 times) were totally as in the protocol. Conclusions: The quality of CPR given by the senior citizens was inadequate in this study. The EMDs had bad protocol compliance. Standardized and feasible T-CPR instructions by the dispatcher are not seen in this study, even if the rescuers stated that the instructions were clear and easy to understand.

  • 96.
    Haupt, Dan
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Aftertreatment strategy for reducing emissions from an ethanol fueled CI engine2009Inngår i: SAE 2009 International Powertrains, Fuels & Lubricants Meeting: June 15 - 17, 2009, Grand Hotel Mediterraneo, Florence, Italy ; [papers], Warrendale, Pa.: Society of Automotive Engineers, Incorporated , 2009Konferansepaper (Fagfellevurdert)
    Abstract [en]

    A nine liters ethanol-fueled CI engine was equipped with aftertreatment devices while different ratios of exhaust gas recirculation (EGR) were tested. The NO\dX emissions were negatively correlated to the EGR-ratio and NO\dX reductions of between 33% and 73% were obtained. Unfortunately, the decrease in NO\dX was followed by increased emissions of carbon monoxide, hydrocarbons, particulate matter and higher fuel consumption. The particle number emission increased approximately 4 times and particle sizes above 200 nm became more frequent when using EGR. The remedy for these emissions was to combine an oxidation catalyst and a diesel particle filter (DPF), while keeping the EGR-ratio low to minimize fuel consumption. Equipped like this, the engine passed the Euro 5 regulation as well as the Enhanced Environmentally Friendly Vehicles standard (EEV).

  • 97.
    Haupt, Dan
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    The role of prescribed and defined daily doses in pharmacoepidemiology2006Inngår i: W H O Drug Information, ISSN 1010-9609, Vol. 20, nr 4, s. 261-264Artikkel i tidsskrift (Fagfellevurdert)
  • 98.
    Haupt, Dan
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Krigsman, Kristin
    NEPI Foundation.
    Nilsson, J. Lars G.
    NEPI Foundation.
    Medication persistence among patients with asthma/COPD drugs2008Inngår i: Pharmacy World & Science, ISSN 0928-1231, E-ISSN 1573-739X, Vol. 30, nr 5, s. 509-514Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective To determine medication possession ratio (MPR) of patients with asthma/COPD drugs. Method Individual patient's volumes of asthma/COPD drugs (ATC-code R03) for 2000-2004 were obtained from a pharmacy record database. For each patient the MPR was calculated as the percentage of the treatment time that the patient had drugs available. Main outcome measure Medication possession ratio (MPR). Results A total of 1,812 patients, 20 years and older, with dispensed asthma/COPD drugs were registered in the database, 928 patients (51%) had acquired drugs less than once per year (68% for 20-29 years old) during the 5-year study. Only 13% of the patients had steroids and steroid combinations available to allow continuous treatment. Eight percent of the patients 20-29 years old had MPR >/= 80% of all the included drugs and 5% when only steroids and steroid combinations were considered. About 25% of the patients had acquired 80% of the total volume of asthma/COPD drugs. Conclusion The majority of the patients, and particularly those in the youngest age group used asthma/COPD drugs only sporadically. This may indicate undermedication which is likely to have a negative impact on patient outcome.

  • 99.
    Haupt, Dan
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Nilsson, J. Lars G.
    NEPI Foundation.
    Asthma medication: persistence with adrenergics, steroids and combination products over a 5-year period2009Inngår i: Journal of clinical pharmacology, ISSN 0091-2700, E-ISSN 1552-4604, Vol. 34, nr 5, s. 507-513Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: Many patients with asthma underuse steroids for inhalation. This has been identified as a main cause of therapy failure and of excess health care utilization.Objective: To elucidate the medication persistence of patients using asthma drugs, how patients combine the drugs over time and whether medication persistence was influenced by patients switching to combination products.Methods: Individual patients' drug acquisition data were obtained from a pharmacy record database for the period 2000-2004. A patient was considered to have satisfactory medication possession ratio (MPR) if the medication supplies covered ≥80% of the prescribed treatment. Drug use profiles were constructed as graphs for each patient, showing the date of each refill and the time period covered by the dispensed drugs. From the graphs the combination of drugs, the continuity of the therapy over time and the MPR for each patient could be determined.Results: Of 1812 patients with asthma drugs in the database, 815 fulfilled the inclusion criteria. The percentage of patients with satisfactory MPR was low (11-27%), but significantly higher among patients using combination products than among those using steroids. For patients who switched from adrenergics plus steroids in two inhalers to combination products in one inhaler, the number of patients with satisfactory MPR was significantly increased.Conclusion: Satisfactory MPR was low for all types of asthma drugs. More patients had satisfactory MPR with combination products in one inhaler than with adrenergics and steroids in two separate inhalers. Asthma drug-delivery is important and combination products of the two ingredients could therefore improve asthma therapy.

  • 100.
    Haupt, Dan
    et al.
    Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
    Nilsson, J.L.G.
    NEPI Foundation.
    Asthma/COPD drugs: PDDs are critical to determining DDDs2006Inngår i: W H O Drug Information, ISSN 1010-9609, Vol. 20, nr 4, s. 261-264Artikkel i tidsskrift (Fagfellevurdert)
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