Columbite-tantalite can accommodate considerable amounts of uranium and excludes lead almost completely. It is thus potentially suited for U-Pb dating. Discordias generally yield closely constrained upper intercept ages. Yet, in a few cases, the U-Pb system of columbite-tantalite gives poorly constrained ages due to excess scatter or inverse discordance. These anomalous features do not show any relation with gross mineral chemistry or pegmatite fractionation. Recrystallization or the presence of exsolutions and inclusions generally do not result in anomalous and scattered U-Pb systematics, unless the inclusions are uraninite or secondary Nb, Ta-bearing phases. Open-system behavior of uraninite, whose occurrence seems to be related to the local host-rock-influenced redox conditions during pegmatite crystallization, often results in inverse discordance. Secondary Nb, Ta-bearing phases that accept Pb and U derived from uraninite inclusions into their structure may inherit this inverse discordance.