Summary The mechanical impedance of the hand and arm was studied on ten healthy subjects during exposure to sinusoidal vibration within the frequency range of 2 to 1000 Hz. A special handle for the measurements was constructed. The influence of vibration direction, handle grip, grip force, vibration level, hand-arm posture and sex as well as anthropometric data were studied. The results show that the impedance of the hand-arm mainly depends on the frequency and direction of the vibration stimuli. Higher vibration levels, as well as more firm hand-grips, resulted in higher impedance. Furthermore, the outcome shows that experiments conducted with different hand-arm postures had an active influence on the mechanical impedance. Moreover, the subjects' sex and constitution of the hand and arm affected the impedance to a large extent.