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Synthesis of ZIF-8/PVA microspheres with the assistance of a microfluidic device and their controlled drug release properties
College of Mechanical and Power Engineering, Nanjing Tech University, Nanjing, 211800, China.
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing 211800, China.
College of Chemical and Environmental Engineering, Jiangsu University of Technology, Changzhou 213001, Jiangsu, PR China.
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing 211800, China.
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2024 (English)In: Microporous and Mesoporous Materials, ISSN 1387-1811, E-ISSN 1873-3093, Vol. 376, article id 113187Article in journal (Refereed) Published
Abstract [en]

The ZIF-8/PVA microdroplets were first generated in a simple co-flow microfluidic device using a PVA aqueous solution dispersed with ZIF-8 nanoparticles as the dispersed phase and fatty acid methyl ester (FAME) as the continuous phase. Subsequently, the ZIF-8/PVA microdroplets were further extracted to form ZIF-8/PVA microspheres. The influence of the type of continuous phase on the sphericity of microspheres was investigated and the effect of ZIF-8 content was studied. Further studies showed that decreasing the extraction rate and using additives of NaCl in the dispersed phase could improve the sphericity of the ZIF-8/PVA microspheres. Finally, the synthesized ZIF-8/PVA microspheres were used to study the loading and release of tetracycline. The results showed that the loading of ZIF-8/PVA microspheres was more than 5 times higher than that of pure PVA microspheres. The drug release time of ZIF-8/PVA microspheres was much longer than that of the PVA microspheres and the release rate was significantly affected by the pH of the environment.

Place, publisher, year, edition, pages
Elsevier B.V. , 2024. Vol. 376, article id 113187
Keywords [en]
Controlled drug release, Microfluidics, Solvent extraction, Sphericity control, ZIF-8/PVA microspheres
National Category
Electrical Engineering, Electronic Engineering, Information Engineering Chemical Engineering
Research subject
Chemical Technology
Identifiers
URN: urn:nbn:se:ltu:diva-105847DOI: 10.1016/j.micromeso.2024.113187Scopus ID: 2-s2.0-85193976047OAI: oai:DiVA.org:ltu-105847DiVA, id: diva2:1865575
Note

Funder: Natural Science Basic Research project of Changzhou (CJ20235065);

Full text license: CC BY

Available from: 2024-06-05 Created: 2024-06-05 Last updated: 2024-06-05

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Yu, Liang

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3637383940414239 of 79
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