The counterfeit medication infiltration within global supply chains poses a major public health threat. To address this, a collaborative effort among governments, regulators, and pharmaceutical companies is essential to secure the global/local supply chain. This paper proposes a novel approach that leverages blockchain technology, polymorphic encryption, and cloud storage to tackle security risks and privacy concerns in medication supply chains. The framework integrates a drug supply chain decentralized application (also called SCMapp) within the Ethereum blockchain, enabling functionalities like secure supplier onboarding, encrypted data management, cloud storage integration, and efficient data retrieval. This approach aims to revolutionize drug supply chain management by enhancing security, transparency, and overall efficiency, ensuring adherence to global health regulations. A safe and effective method for managing drug supply chains is provided by the suggested Drug Supply Chain Management System. The proposed model outperformed existing solutions in terms of security, efficiency, and traceability. The combination of encryption, blockchain, and cloud storage provided a comprehensive approach to address the challenges of drug supply chain management. The comparison analysis highlighted the unique advantages of the proposed model over other methods.