This research presents a systematic review of the relationship between biophilic architecture and sustainability in the context of building design. In the contemporary era, the challenge of climate change is a crucial aspect that must be responded to in architectural practice, but in reality, the design and construction process still often prioritizes aesthetics and function alone without considering ecological impacts. This imbalance has led to the degradation of urban ecosystems and a decline in the quality of environmental sustainability. In this context, biophilic architecture emerges as a strategic approach that integrates natural elements directly into the built space to enhance psychological well-being and reduce user stress levels. The literature review reveals that while sustainable design tends to emphasize technical solutions, the application of biophilic principles offers a more holistic, adaptive, and human-oriented approach. This study confirms the urgency of developing a more integrative architectural paradigm, where the presence of natural elements is positioned as an essential component in shaping a resilient built environment that supports the health and well-being of its users. Thus, the integration of biophilic strategies in sustainable design not only strengthens environmental performance but also has a positive impact on psychological aspects and human health.