This chapter addresses the interplay of IS development and IT operations in system development projects, as seen from the perspective of IT operations. The underlying perspective is that a well-performed interplay of the two domains is essential, both for the successful development of a new information system, as well as for its subsequent operation. In this chapter, we use alignment theory to analyse data from a Delphi study in order to investigate the interplay of the two areas. The chapter concludes that the two areas are often unsatisfactorily aligned and that improving their interplay must be a priority for IS development and IT operations alike.