An integrated design of material and process is necessary when designing a component where the effect of the manufacturing route on its performance must be accounted for. This is particularly the case for welded components even when post weld heat treatment is performed. The paper describes developments done at Luleå University of Technology in cooperation with Volvo Aero in the Swedish National Programme for Aeronautical Research (NFFP) and in different European projects. The paper focuses on two particular issues of importance. The first is of more administrative character, the transfer of data between different finite element models used in each of the manufacturing steps. The other aspect is the extremely important issue of material modeling.Material models for simulation of a chain of manufacturing processes include additional complications besides large variations in strain rates and temperatures. These complications are caused by the changing microstructure that may occur. The authors expect that physically based models can have a larger range of applicability than engineering type of models. Physical based models are formulated by considering the underlying physics of the deformation whereas engineering type of models are more of a curve-fitting nature. The physical based models may also have a natural coupling to models of the microstructure evolution. However, the models must still be tractable for large-scale computations. Thus, they should be of the internal state variable type with relatively few additional parameters and equations to solve at the integration point level of finite elements. The paper describes a basic dislocation density model used in modelling different manufacturing processes and how it can be coupled to microstructure models. It is based on dislocation glide as the dominating mechanism for the plastic deformation. This may be models for phase changes, like in Ti6-4, or precipitate growth/dissolution as in Alloy 718. The coupled models will not only make it possible to describe the material behavior more correct over the process cycles but also predict the obtained microstructure. It is expected that future research may couple this information with defect predictions in order to contribute to life assessment. The paper includes some example of manufacturing simulations and also an example of simulation of a chain of manufacturing processes.