Solar-driven hydrogen production is one of the most promising strategies for solar-to-hydrogen energy conversion. Compared to inorganic quantum dots (QDs), carbon quantum dots (C-dots) have attracted a lot of attention for optoelectronic devices due to their structure-dependent optical properties and green composition. However, the solar-to-hydrogen conversion efficiency of most of the photoelectrochemical (PEC) devices based on colloidal QDs is still low. Here we demonstrated a highly efficient and stable ecofriendly PEC device using C-dots sensitized TiO₂ photoanode, Pt loaded on carbon nanofibers as counter electrode, and glucose aqueous solution as electrolyte. The red-color C-dots were prepared using a solvothermal reaction, with an absorption spectrum ranging from 300 to 600 nm and a quantum yield (QY) of 50%. The C-dots have excitation independent photoluminescence peak positions and highly crystalline structure. The hydroxyl group on the C-dots can strongly interact with the TiO₂, forming a very stable complex. Benefiting from these features, the PEC devices based on C-dots exhibit a saturated photocurrent density as high as ~4 mA/cm² at 0.6 V vs. RHE and the device is very stable (keeping 95% of its initial value after 10-hour illumination upon 100 mW/cm²). This work indicates the promising properties of the C-dots/TiO₂ system, which holds huge potential for applications in the fields of optoelectronic and catalytic devices.