Utilization of carbon dioxide (CO₂) has attracted great research interests, because CO₂ is both a typical greenhouse gas and renewable carbon resource. This review mainly summarized and reviewed the research work linked to the challenges in the enzymatic conversion of CO₂, such as NADH regeneration and low CO₂ conversion efficiency. Based on the summary on the electro-enzymatic conversion of CO₂, ionic liquids for the enzymatic conversion of CO₂, and ionic liquids for the electrochemical conversion of CO₂, we suggested applying ionic liquids as co-solvent in the enzymatic conversion of CO₂ to methanol and coupling it with the reduction of NAD⁺ to NADH by electrocatalysis, providing a novel pathway for producing methanol from CO₂.