As a novel network infrastructure that realizes the interconnection of humans, machines, and things, the 5G-based or blockchain-based applications have been widely deployed in the Industrial Internet of Things (IIoT). However, there are still many challenges to be solved, such as poor scalability, low efficiency, and privacy leakages. In the special issue, we present eight advanced solutions in data analysis, secure communication, authentication, access control, and data deduplication.