As the routine operations are starting to become highly automated, it is crucial to develop autonomous solutions that are infrastructure independent. Achieving this is challenging due to the ever-changing landscape of mines, which complicates infrastructure development. In response, this paper introduces a robust framework employing drones to gather data from hard-to-access areas in mines and deliver the data back to the base station for routine monitoring purposes. These tasks include gathering data from operational vehicles (mine trucks, loaders etc.), as well as various sensors (e.g. monitoring rock bolts) and relaying the data to the mine’s base station for monitoring purposes. The proposed framework is based on autonomous navigation using a known point cloud map of the mine, proximity detection via Ultra WideBand (UWB) radios and the data transfer is accomplished through the IEEE 802.15.4 communication standard, operating in the 868 MHz ISM band, with the aim to guarantee long range operation. On the mission level, the drones act as data mules capable of autonomously extracting data from operating vehicles, storing the data onboard and eventually delivering the data to the base station, which is enabled through a Point and Click (PAC) autonomy framework based on global planning, reactive navigation, communication link and behavior management. The efficacy of this framework has been demonstrated through real-world experiments conducted at a test mine in Sweden, validating the overall architecture of the proposed solution.