An original multiobjective optimization method is used to support the generation of a new family of profiles for two-dimensional cascades suitable for subsonic compressors. The aim of the optimization is to maximize the pressure ratio and to minimize the profile losses of a cascade, while conforming to a functional constraint on the operating range. The method uses an evolutionary algorithm featuring a novel evaluation technique conceived for multiobjective problems and a blade-to-blade inviscid/viscous solver for calculating flow quantities. As an example, an excerpt of optimized profiles is presented, and their performances are compared with those of conventional NACA 65 profiles. The new profiles show superior design performances both in efficiency and pressure rise, as well as a tolerance to incidence angles comparable to conventional profiles. The reasons of this improvement are discussed in detail on the basis of rigorous loss analysis.